MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species.

Autor: Roider E; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, USA. Elisabeth.Roider@usb.ch.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA. Elisabeth.Roider@usb.ch.; Department of Dermatology, University Hospital of Basel, Basel, Switzerland. Elisabeth.Roider@usb.ch., Lakatos AIT; HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary.; Department of Physiology, Semmelweis University, Budapest, Hungary.; Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary., McConnell AM; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Massachusetts and the Howard Hughes Medical Institute, Boston, USA., Wang P; Department of Pharmaceutical Sciences, Department of Chemistry and Chemical Biology, and Barnett Institute, Bouve College, Northeastern University, Boston, MA, 02115, USA., Mueller A; Department of Dermatology, University Hospital of Basel, Basel, Switzerland., Kawakami A; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, USA., Tsoi J; Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.; UCLA Metabolomics Center, University of California, Los Angeles (UCLA), Los Angeles, CA, USA., Szabolcs BL; HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary.; Department of Physiology, Semmelweis University, Budapest, Hungary.; Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary., Ascsillán AA; HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary.; Department of Physiology, Semmelweis University, Budapest, Hungary.; Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary., Suita Y; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, USA., Igras V; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, USA., Lo JA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, USA., Hsiao JJ; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, USA., Lapides R; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.; Robert Larner, College of Medicine at the University of Vermont, Burlington, USA., Pál DMP; HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary.; Department of Physiology, Semmelweis University, Budapest, Hungary.; Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary., Lengyel AS; HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary.; Department of Physiology, Semmelweis University, Budapest, Hungary.; Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary., Navarini A; Department of Dermatology, University Hospital of Basel, Basel, Switzerland., Okazaki A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA., Iliopoulos O; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA., Németh I; Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary., Graeber TG; Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.; UCLA Metabolomics Center, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.; Crump Institute for Molecular Imaging, UCLA, Los Angeles, CA, USA., Zon L; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Massachusetts and the Howard Hughes Medical Institute, Boston, USA., Giese RW; Department of Pharmaceutical Sciences, Department of Chemistry and Chemical Biology, and Barnett Institute, Bouve College, Northeastern University, Boston, MA, 02115, USA., Kemeny LV; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, USA. Kemeny.lajos@semmelweis.hu.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA. Kemeny.lajos@semmelweis.hu.; HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary. Kemeny.lajos@semmelweis.hu.; Department of Physiology, Semmelweis University, Budapest, Hungary. Kemeny.lajos@semmelweis.hu.; Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University, Budapest, Hungary. Kemeny.lajos@semmelweis.hu., Fisher DE; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, USA. dfisher3@mgh.harvard.edu.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA. dfisher3@mgh.harvard.edu.; Lancer Professorship of Dermatology, Harvard Medical School, Boston, USA. dfisher3@mgh.harvard.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Sep 14; Vol. 14 (1), pp. 21527. Date of Electronic Publication: 2024 Sep 14.

Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction.

Autor: Pla I, Szabolcs BL, Péter PN, Ujfaludi Z, Kim Y, Horvatovich P, Sanchez A, Pawlowski K, Wieslander E, Guedes J, Pál DM, Ascsillán AA, Betancourt LH, Németh IB, Gil J, de Almeida NP, Szeitz B, Szadai L, Doma V, Woldmar N, Bartha Á, Pahi Z, Pankotai T, Győrffy B, Szasz AM, Domont G, Nogueira F, Kwon HJ, Appelqvist R, Kárpáti S, Fenyö D, Malm J, Marko-Varga G, Kemény LV

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 12. Date of Electronic Publication: 2024 Feb 12.