Zobrazeno 1 - 10
of 7 215
pro vyhledávání: '"Ascierto P"'
Autor:
Ralf Gutzmer, Ulrike Leiter, Peter Mohr, Katharina C. Kähler, Paolo Antonio Ascierto, Massimiliano Scalvenzi, Ketty Peris, Gemma María Pérez-Pastor, Ricardo Fernández-de-Misa, Rafael Botella-Estrada, Robert E. Hunger, Serena Martelli, Nur Güneli, Ramon Arntz, Axel Hauschild
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Following the pivotal phase II trial BOLT, the Hedgehog (Hh) inhibitor sonidegib was approved in the EU to treat locally advanced basal cell carcinoma (laBCC) in patients not amenable to surgery or radiotherapy. We report safety d
Externí odkaz:
https://doaj.org/article/f6af041d3b7c44cf9ec6506be11d5de8
Autor:
Alessandro Lavoro, Luca Falzone, Giuseppe Gattuso, Giuseppe N. Conti, Rosario Caltabiano, Gabriele Madonna, Mariaelena Capone, James A. McCubrey, Paolo A. Ascierto, Massimo Libra, Saverio Candido
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Cancer onset and progression are driven by genetic and epigenetic alterations leading to oncogene activation and the silencing of tumor suppressor genes. Among epigenetic mechanisms, DNA methylation (methDNA) is gaining growing in
Externí odkaz:
https://doaj.org/article/aceb0e12d2e74b42a6c2049cf1cf8200
Autor:
Matteo Pallocca, Ivan Molineris, Enrico Berrino, Benedetta Marcozzi, Martina Betti, Lauretta Levati, Stefania D’Atri, Chiara Menin, Gabriele Madonna, Paola Ghiorzo, Jenny Bulgarelli, Virgina Ferraresi, Tiziana Venesio, Monica Rodolfo, Licia Rivoltini, Luisa Lanfrancone, Paolo Antonio Ascierto, Luca Mazzarella, Pier Giuseppe Pelicci, Ruggero De Maria, Gennaro Ciliberto, Enzo Medico, Giandomenico Russo
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/db0694483e1844d0a738cba9df9e8e28
Autor:
Peter Mohr, Paolo Ascierto, Alfredo Addeo, Maria Grazia Vitale, Paola Queirolo, Christian Blank, Jussi Ekström, Joonas Vainio, Vesa Kataja, Sibel Gunes, Mia Engström-Risku, Henriette Thole, Ailis Fagan, Frederico Calado, Ruben Marques, Judith Lijnsvelt
Publikováno v:
EJC Skin Cancer, Vol 2, Iss , Pp 100254- (2024)
Background: The Kaiku Health platform is an electronic patient-reported outcome (ePRO) system aimed at monitoring symptoms and quality of life (QoL) among cancer patients. ePRO systems allow timely interventions to symptoms, which has been shown to i
Externí odkaz:
https://doaj.org/article/ae6b4f22ff6149688275024e75f05281
Autor:
Michael Weichenthal, Inge Marie Svane, Johanna Mangana, Ulrike Leiter, Friedegund Meier, Christina Ruhlmann, Dimitrios Ziogas, Reinhard Dummer, Pablo Cerenzuela, Jose Luis Manzano, Marc Bender, Shan Jiang, Paolo Antonio Ascierto, Iva Gavrilova, Lidija Kandolf, Helen Gogas, Peter Mohr, Dirk Schadendorf, Eva Ellebaek
Publikováno v:
EJC Skin Cancer, Vol 2, Iss , Pp 100271- (2024)
Background: Postoperative treatment of patients with either BRAF/MEK inhibitors or anti-PD1 antibodies in the adjuvant setting results in improved recurrence free survival and has therefore become a standard of care for most patients with resected st
Externí odkaz:
https://doaj.org/article/6497af80a5374a6f94e7a339168a3441
Autor:
Sara Parola, Christoph Oing, Pasquale Rescigno, Salvatore Feliciano, Francesca Carlino, Luca Pompella, Antonella Lucia Marretta, Irene De Santo, Martina Viggiani, Margherita Muratore, Bianca Arianna Facchini, Jessica Orefice, Eleonora Cioli, Francesca Sparano, Domenico Mallardo, Ugo De Giorgi, Giovannella Palmieri, Paolo Antonio Ascierto, Margaret Ottaviano
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Testicular germ cell tumors (TGCTs), the most common malignancies affecting young men, are characterized by high sensitivity to cisplatin-based chemotherapy, which leads to high cure rates even in metastatic disease. However, approximately 30% of pat
Externí odkaz:
https://doaj.org/article/21d9e0853dee4280af70c686b4623c29
Autor:
Pedro J Romero, Bernard A Fox, Iman Osman, Omid Hamid, Paolo A Ascierto, Michael T Lotze, Jason John Luke, James J Mulé
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)
Externí odkaz:
https://doaj.org/article/85e7b8c75928474dbab1de8b38426b34
Autor:
Alberto Mendoza‐Valderrey, Jane Choe, Daria M. Kessler, Gianna Jimenez, Xinmin Li, Steven Kolker, Warren Allen, Jennifer A. Linehan, Przemyslaw W. Twardowski, Maria Libera Ascierto
Publikováno v:
Cancer Medicine, Vol 13, Iss 15, Pp n/a-n/a (2024)
Abstract Background Neoadjuvant cisplatin‐based chemotherapy (NAC) followed by cystectomy is the standard of care for patients with muscle‐invasive bladder cancer (MIBC). Pathologic complete response (pCR) is associated with favorable outcomes, b
Externí odkaz:
https://doaj.org/article/02d7ef7048a2464ca5aae28cc305f034
Autor:
Alexandra Leary, Paolo A Ascierto, Michele Maio, Georgia Kollia, Jennifer Friedmann, Marina Tschaika, Patrick Schöffski, Jonathan Baden, Neeltje Steeghs, Parul Doshi, Massimo Di Nicola, Jean-Pierre Delord, Iwona Lugowska, Mauricio Burotto, David S P Tan, Anthony Gonçalves, Michael Schenker, Ning Huang, Tudor-Eliade Ciuleanu, Martin Richardet, Lorena Lupinacci, Julieta Grasselli, Jacqueline Vuky, Somasekhar Konduru, Sai Vikram Vemula, Ruta Slepetis, Misena Pacius, Quyen Duong
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 8 (2024)
Background Checkpoint inhibitor therapy has demonstrated overall survival benefit in multiple tumor types. Tumor mutational burden (TMB) is a predictive biomarker for response to immunotherapies. This study evaluated the efficacy of nivolumab+ipilimu
Externí odkaz:
https://doaj.org/article/be397a2c9d104c41b010a59bc9500941
Autor:
Luigi Scarpato, Marco Palla, Sabino Strippoli, Luca Tagliaferri, Luca Fania, Maristella Saponara, Anna Carbone, Francesco Spagnolo, Flavia Silvestri, Paolo Antonio Ascierto
Publikováno v:
Dermatology Reports (2024)
Basal cell carcinoma (BCC) is the most common malignant tumour in white populations. Multiple studies demonstrated that the aberrant activation of Hedgehog signaling is a driver of BCC development, and its blockade represents a potential therapeutic
Externí odkaz:
https://doaj.org/article/532de72c851f4cdb8b02316ca70fc097