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pro vyhledávání: '"Ascher, DB"'
Pyrazinamide (PZA), which is an analogue of nicotinamide, is an important first-line drug used in the short-course treatment of tuberculosis. PZA is a prodrug devoid of significant antibacterial activity. It is metabolized into its active form, pyraz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f7ed1a63cfc19d1d0d45580c87962d
INTRODUCTION: Mutations introduce diversity into genomes, leading to selective changes and driving evolution. These changes have contributed to the emergence of many of the current major health concerns of the 21st century, from the development of ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c51f1c92df94b7ea0e67ed46c17190
Here, we report a webserver for the improved SDM, used for predicting the effects of mutations on protein stability. As a pioneering knowledge-based approach, SDM has been highlighted as the most appropriate method to use in combination with many oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::7402fd85556c3e3ad9e33e6b0163fcfb
https://www.repository.cam.ac.uk/handle/1810/266306
https://www.repository.cam.ac.uk/handle/1810/266306
Autor:
Pires, DEV, Ascher, DB
Over the past two decades, several computational methods have been proposed to predict how missense mutations can affect protein structure and function, either by altering protein stability or interactions with its partners, shedding light into poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::5beae84edd42af3874def2aabe6d6bc7
https://www.repository.cam.ac.uk/handle/1810/265096
https://www.repository.cam.ac.uk/handle/1810/265096
Autor:
White, RR, Ponsford, AH, Weekes, MP, Rodrigues, RB, Ascher, DB, Mol, M, Selkirk, ME, Gygi, SP, Sanderson, CM, Artavanis-Tsakonas, K
$\textit{Trichinella spiralis}$ is a muscle-specific parasitic worm that is uniquely intracellular. $\textit{T. spiralis}$ reprograms terminally differentiated skeletal muscle cells causing them to de-differentiate and re-enter the cell cycle, a proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b523a473226584abfa1fa695d912cb6
Here, we report a webserver for the improved SDM, used for predicting the effects of mutations on protein stability. As a pioneering knowledge-based approach, SDM has been highlighted as the most appropriate method to use in combination with many oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4580cfe38143efd78f51631b6757b84
Interactions between proteins and their ligands, such as small molecules, other proteins, and DNA, depend on specific interatomic interactions that can be classified on the basis of atom type and distance and angle constraints. Visualisation of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be3303e31dbd11ec3d9a5850ffe93ae3
Autor:
Casey, RT, Ascher, DB, Rattenberry, E, Izatt, L, Andrews, KA, Simpson, HL, Challis, B, Park, S-M, Bulusu, VR, Lalloo, F, Pires, DEV, West, H, Clark, GR, Smith, PS, Whitworth, J, Papathomas, TG, Taniere, P, Savisaar, R, Hurst, LD, Woodward, ER, Maher, ER
Purpose To evaluate the role of germline SDHA mutation analysis by (1) comprehensive literature review, (2) description of novel germline SDHA mutations and (3) in silico structural prediction analysis of missense substitutions in SDHA. Patients and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82ef3368f87f3afa863e7f5c6f7e3de6
For over four decades structural biology has been used to understand the mechanisms of disease, and structure-guided approaches have demonstrated clearly that they can contribute to many aspects of early drug discovery, both computationally and exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e1ef680ddd1510c6d130e76048d9453
When double-strand breaks (DSBs) in DNA remain unrepaired, catastrophic loss of genes occurs, leading to translocations, mutations and carcinogenesis. If a sister chromatid is not available at the DNA DSB, nonhomologous end joining (NHEJ) is used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beb7b963fc160cb96c0bff4882067303