Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ascensión Heredia"'
Autor:
José Palacios, Josep Bou, Teresa Doménech, Ascensión Heredia, Jaume Puig, Dolors Fernández-Forner, Jordi Gras, Jorge Beleta
Publikováno v:
European Journal of Pharmacology. 410:33-41
Almotriptan (3-[2-(dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl )-1H-indo le) has been studied in several models predictive of activity and selectivity at 5-HT receptors. Almotriptan showed low nanomolar affinity for the 5-HT(1B) and 5-HT(1D
Autor:
Victor Segarra, MA López, Montserrat Miralpeix, Josep M. Huerta, Ascensión Heredia, Ignasi Cardelús, Jaume Puig, José Palacios, Hamish Ryder, Nuria Godessart, María I. Crespo, Carles Puig, Joan Feixas, Javier Ibarzo, Jordi Beleta, Juan-Miguel Jimenez, Lidia Soca
Publikováno v:
Journal of Medicinal Chemistry. 43:214-223
A series of 3,4-diaryloxazolones were prepared and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2). Extensive structure-activity relationship work was carried out within this series, and a number of potent and selective COX-2 inhibito
Publikováno v:
Archives of Biochemistry and Biophysics. 333:198-206
Melanoma cells produce a cell-specific proteoglycan, mel-PG, which is an integral chondroitin sulfate proteoglycan that can be released into the medium as a result of the proteolytic cleavage of the trans-membrane form. The effect of transforming gro
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1093:229-233
The effect of transforming growth factor beta (TGF-beta) on the biosynthesis of individual proteoglycans (PGs) by human embryonic lung fibroblasts has been investigated using specific antibodies and cDNA probes. Human lung fibroblasts secrete the two
Publikováno v:
Cancer letters. 109(1-2)
The effect of transforming growth factor beta 1 (TGF-beta 1) on cell proliferation, colony formation in soft agar and synthesis and structure of proteoglycans was studied in three human melanoma cell lines at different stages of differentiation: SK-m
Publikováno v:
Biochemical and biophysical research communications. 200(2)
ts371 KiMuSV-transformed rat kidney fibroblasts growing at the permissive temperature to allow the expression of a transforming p21 ras protein secrete a different pattern of chondroitin/dermatan sulfate proteoglycans than when growing at the non-per
Publikováno v:
Analytica Chimica Acta. 187:147-155
The use of the inclusion complex of 1-amino-4-hydroxyanthraquinone (AHA) in the internal cavity of β-cyclodextrin is compared with AHA alone as a ligand for the spectrofluorimetric determination of beryllium. The organizing ability of the cyclodextr