Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Asbjörn Punkenhofer"'
1
Novel High Energy Intermediate Analogues with Triazasterol-related Structures as Inhibitors of the Ergosterol Biosynthesis V [1]. Synthesis of Hexahydro-5H-imidazo[1?, 2?: 1,2]pyrimido-[4,3-a]isoquinolines and 1-Alkyl Analogues Representing New 8,13,15-Triazasteroids
Autor: Asbjörn Punkenhofer, Edith Gößnitzer
Publikováno v: Monatshefte f�r Chemie / Chemical Monthly. 134:1271-1282
The synthesis of 1,2,6,10b,11,12-hexahydro-5H-imidazo[1′,2′:1,2]pyrimido[4,3-a]isoquinolines representing new types of 8,13,15-triazasteroids is described. The tetracyclic title compounds were prepared from 4-(2-hydroxyalkylamino)tetrahydro-2H-py
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70954d4361872a0f0a3dcba460a3fc0f
https://doi.org/10.1007/s00706-003-0038-9
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2
Novel High Energy Intermediate Analogues with a Triazasterol Structure as Potential Ergosterol Biosynthesis Inhibitors IV: Antimicrobial Activity of Mono-, Bi-, and Tricyclic 8, 13, 15-Triazasteroid Analogues Including the Synthesis of Novel 4-Alkylamino- and 4-Alkenylamino-9-hydroxypyrimidoisoquinolines
Autor: Neil S. Ryder, Asbjörn Punkenhofer, Edith Gößnitzer
Publikováno v: Archiv der Pharmazie. 336:336-344
4-alkylamino-and 4-alkenylamino-9-hydroxy-1, 6, 7, 11b-tetrahydro-2H-pyrimido[4, 3-a]isoquinolines were designed as inhibitory tricyclic triaza-analogues of carbocationic high energy intermediates (HEI) of enzymes involved in fungal ergosterol biosyn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad69c99e20f91011efb78a3d67a73bfa
https://doi.org/10.1002/ardp.200300774
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3
Novel high energy intermediate analogues with triazasterol-related structures as inhibitors of ergosterol biosynthesis
Autor: Edith Gößnitzer, Anton Amon, Asbjörn Punkenhofer, Bertrand Favre
Publikováno v: European Journal of Pharmaceutical Sciences. 19:151-164
A series of N4-alkyl-1,6,7,11b-tetrahydro-2H-pyrimido[4,3-a]isoquinolinamine hydroiodides with triazasterol-related structures was designed and synthesized to mimic, as stable analogues, native high energy intermediates (HEI) of ergosterol biosynthes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::322e7af5f119372a61b8631398a06cc3
https://doi.org/10.1016/s0928-0987(03)00086-1
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4
Novel High Energy Intermediate Analogues with Triazasterol-Related Structures as Potential Inhibitors of the Ergosterol Biosynthesis II [1]. Optimization of the Synthesis of 1,6,7,11b-Tetrahydro-2 H pyrimido[4,3- a ] isoquinolin-4-amines as Parent Compounds of Novel 8,13,15-Triazasteroids
Autor: Edith Gößnitzer, Asbjörn Punkenhofer
Publikováno v: Monatshefte f�r Chemie / Chemical Monthly. 134:909-927
Various routes for an effective synthesis of 1,6,7,11b-tetrahydro-2H-pyrimido[4,3-a]isoquinolin-4-amine and its 9-methoxy derivative, which were designed as tricyclic triaza-analogues with stable positive charge to mimic carbocationic high energy int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c7dc30f18eae0a85196c5de75fdcf50
https://doi.org/10.1007/s00706-002-0559-7
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