Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Asami Mori"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1106 (2024)
Glaucoma is one of the leading causes of acquired blindness and characterized by retinal ganglion cell (RGC) death. MicroRNAs are small noncoding RNAs that degrade their target mRNAs. Apoptosis is one of the common mechanisms leading to neuronal deat
Externí odkaz:
https://doaj.org/article/54b2c8ac3b974f78a80902dc19ca60a3
Autor:
Asami Mori, Daiki Sumida, Ryo Kondo, Ayuki Nakano, Shiho Arima, Daiki Asano, Akane Morita, Kenji Sakamoto, Tohru Nagamitsu, Tsutomu Nakahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 146, Iss 4, Pp 233-243 (2021)
Retinopathy of prematurity (ROP) is a proliferative retinal vascular disease, initiated by delayed retinal vascular growth after premature birth. In the majority of cases, ROP resolves spontaneously; however, a history of ROP may increase the risk of
Externí odkaz:
https://doaj.org/article/ba57ba31858e4cb39508f18a536b5a2a
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1403 (2022)
We previously identified that NO derived from neuronal cells acts on glial cells and causes vasodilation in the healthy rat retina via the release of epoxyeicosatrienoic acids (EETs) and prostaglandins (PGs) by activation of the arachidonic acid casc
Externí odkaz:
https://doaj.org/article/cd8ecaa747d142eabdc0c5b7dc5cd2a2
Autor:
Naoto Iizuka, Akane Morita, Chihiro Kawano, Asami Mori, Kenji Sakamoto, Masakazu Kuroyama, Kunio Ishii, Tsutomu Nakahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 3, Pp 203-208 (2018)
Pathological retinal angiogenesis contributes to the pathogenesis of several ocular diseases. Valproic acid, a widely used antiepileptic drug, exerts anti-angiogenic effects by inhibiting histone deacetylase (HDAC). Herein, we investigated the effect
Externí odkaz:
https://doaj.org/article/c70d2ab428fb47b9ad5538a8a661646f
Autor:
Asami Mori, Toshiaki Takei, Namiko Suzuki, Kenji Sakamoto, Masahiko Morita, Satoshi Nakagawa, Tsutomu Nakahara, Kunio Ishii
Publikováno v:
Heliyon, Vol 7, Iss 3, Pp e06532- (2021)
In our previous study, we found that the vasodilation of retinal arterioles induced by acetylcholine and BMS-191011, a large-conductance Ca2+-activated K+ (BKCa) channel opener, were diminished in diabetic rats. Currently, few agents ameliorate the i
Externí odkaz:
https://doaj.org/article/feab66514c9c46fb804c9e454012e9c8
Autor:
Akane Morita, Shohei Sawada, Asami Mori, Shiho Arima, Kenji Sakamoto, Tohru Nagamitsu, Tsutomu Nakahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 136, Iss 4, Pp 177-188 (2018)
Abnormalities in retinal blood vessels and neuronal function persist in eyes undergoing retinopathy of prematurity. In this study, we examined morphological and functional changes in retinal blood vessels and neurons in mice that had undergone short-
Externí odkaz:
https://doaj.org/article/418a71da19a7401b966ba40b8881eae2
Autor:
Yuki Kurauchi, Koichi Mokudai, Masahiko Morita, Ayako Kamimura, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii
Publikováno v:
Journal of Functional Foods, Vol 38, Iss , Pp 540-544 (2017)
We have previously reported that intravenous injection of l-citrulline, an α-amino acid isolated from watermelon juice, prevented the decrease in cerebral blood flow (CBF) during cortical spreading depression (CSD) in rats, a widely accepted animal
Externí odkaz:
https://doaj.org/article/2c42e591d7d54401a195223454bc2053
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 2, Pp 72-80 (2017)
We reported that high-mobility group Box-1 (HMGB1) was involved in excitoneurotoxicity in the retina. HMGB1 is known to activate nuclear factor kappa B (NF-κB). However, the role of NF-κB in excitotoxicity is still controversial. Here, we demon
Externí odkaz:
https://doaj.org/article/b4b3ee6293d542bfbbd85d083189269d
Autor:
Yuki Kurauchi, Koichi Mokudai, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Masahiko Morita, Ayako Kamimura, Kunio Ishii
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 3, Pp 146-155 (2017)
l-Citrulline is a potent precursor of l-arginine, and exerts beneficial effect on cardiovascular system via nitric oxide (NO) production. Migraine is one of the most popular neurovascular disorder, and imbalance of cerebral blood flow (CBF) observed
Externí odkaz:
https://doaj.org/article/f11434366b5e4a7cb599293d9c0039c2
Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats
Autor:
Koki Watanabe, Daiki Asano, Hiroko Ushikubo, Akane Morita, Asami Mori, Kenji Sakamoto, Kunio Ishii, Tsutomu Nakahara
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4439 (2021)
Metformin, an anti-hyperglycemic drug of the biguanide class, exerts positive effects in several non-diabetes-related diseases. In this study, we aimed to examine the protective effects of metformin against N-methyl-D-aspartic acid (NMDA)-induced exc
Externí odkaz:
https://doaj.org/article/42da4571a43a4d92b2e17d1c7931cd8e