Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Asami Hishiki"'
Publikováno v:
Journal of biochemistry. 173(1)
The sliding DNA clamp is a ring-shaped protein that encircles DNA within its central channel. It binds to multiple proteins, such as DNA polymerases and DNA repair enzymes, and stimulates their enzymatic activities, thereby playing a crucial role in
Autor:
Kodai Hara1, Asami Hishiki1, Takako Hoshino1, Kiho Nagata1, Nao Iida1, Yukimasa Sawada1, Eiji Ohashi2, Hiroshi Hashimoto1
Publikováno v:
Journal of Biological Chemistry. Apr2023, Vol. 299 Issue 4, p1-7. 7p.
Publikováno v:
Journal of biochemistry. 172(4)
DNA sliding clamps are widely conserved in all living organisms and play crucial roles in DNA replication and repair. Each DNA sliding clamp is a doughnut-shaped protein with a quaternary structure that encircles the DNA strand and recruits various f
Autor:
Teruki Yanagi, Kiyoshi Tachikawa, Rachel Wilkie-Grantham, Asami Hishiki, Ko Nagai, Ellen Toyonaga, Pad Chivukula, Shu-ichi Matsuzawa
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
PCTAIRE1/CDK16/PCTK1 plays critical roles in cancer cell proliferation and antiapoptosis. To advance our previously published in vitro results with PCTAIRE1 silencing, we examined the in vivo therapeutic potential of this approach by using small inte
Externí odkaz:
https://doaj.org/article/68c6208c85b942e78aaeae5920fa4f0c
Publikováno v:
The Journal of Biochemistry. 167:597-602
Replication fork regression is a mechanism to rescue a stalled fork by various replication stresses, such as DNA lesions. Helicase-like transcription factor, a SNF2 translocase, plays a central role in the fork regression and its N-terminal domain, H
Autor:
Taro Saito, Yutaka Shimizu, Kaori Tsukakoshi, Koichi Abe, Jinhee Lee, Kinuko Ueno, Ryutaro Asano, Brian V. Jones, Tomohiro Yamada, Tatsuki Nakano, Jiaxing Tong, Asami Hishiki, Kodai Hara, Hiroshi Hashimoto, Koji Sode, Toshimasa Toyo’oka, Kenichiro Todoroki, Kazunori Ikebukuro
Publikováno v:
Biosensorsbioelectronics. 203
Therapeutic monoclonal antibodies (mAbs) are successful biomedicines; however, evaluation of their pharmacokinetics and pharmacodynamics demands highly specific discrimination from human immunoglobulin G naturally present in the blood. Here, we devel
Autor:
Satoshi Shimizu, Tatsuya Morimoto, Masafumi Funamoto, Asami Hishiki, Yoichi Sunagawa, Kana Shimizu, Kodai Hara, Yasufumi Katanasaka, Koji Hasegawa, Nurmila Sari, Yusuke Miyazaki, Hiroshi Hashimoto
Publikováno v:
Circulation Research. 129
Introduction: Cardiac hypertrophy is regulated by activation of GATA4. Although GATA4 post-translational modification such as acetylation by p300 is well examined, the details of the activation mechanism of GATA4 are still unclear. The purpose of thi
Publikováno v:
Acta crystallographica. Section D, Structural biology. 76(Pt 8)
HLTF (helicase-like transcription factor) is a yeast RAD5 homolog that is found in mammals. HLTF has E3 ubiquitin ligase and DNA helicase activities, and is a pivotal protein in template-switched DNA synthesis that allows DNA replication to continue
Autor:
Eiji Ohashi, Ryota Tamafune, Yoshinobu Ishikawa, Nao Iida, Kodai Hara, Asami Hishiki, Hitomi Sakurai, Hiroshi Hashimoto
Publikováno v:
J Biol Chem
DNA clamp, a highly conserved ring-shaped protein, binds dsDNA within its central pore. Also, DNA clamp interacts with various nuclear proteins on its front, thereby stimulating their enzymatic activities and biological functions. It has been assumed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c03760be8c91a0f3c19fe9d58f862a
https://europepmc.org/articles/PMC6983850/
https://europepmc.org/articles/PMC6983850/
Autor:
Kana Shimizu, Kodai Hara, Masafumi Funamoto, Yusuke Miyazaki, Yoichi Sunagawa, Tatsuya Morimoto, Satoshi Shimizu, Asami Hishiki, Hiromichi Wada, Sari Nurmila, Hiroshi Hashimoto, Koji Hasegawa, Yasufumi Katanasaka
Publikováno v:
European Heart Journal. 40
Introduction Hypertrophic signals eventually reach the nuclei of cardiomyocytes, change patterns of gene expression, and cause the development of heart failure. During the development of heart failure, intrinsic histone acetyltransferase called p300