Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Asami Hanazawa"'
Autor:
Ikumi Katano, Asami Hanazawa, Iyo Otsuka, Takuya Yamaguchi, Misa Mochizuki, Kenji Kawai, Ryoji Ito, Motohito Goto, Takahiro Kagawa, Takeshi Takahashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer in the clinic. Further discovery of novel drugs or therapeutic protocols that enhance efficacy requires reliable animal models that recapitulate human immune res
Externí odkaz:
https://doaj.org/article/b20ff092b5244208bc65b09380250c63
Autor:
Asami Hanazawa, Ryoji Ito, Ikumi Katano, Kenji Kawai, Motohito Goto, Hiroshi Suemizu, Yutaka Kawakami, Mamoru Ito, Takeshi Takahashi
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The tumor microenvironment contains unique immune cells, termed myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs) that suppress host anti-tumor immunity and promote tumor angiogenesis and metastasis. Although these cel
Externí odkaz:
https://doaj.org/article/7d3f4226ec3e4c38888967177ce80167
Autor:
Motohito Goto, Kenji Kawai, Iyo Otsuka, Riichi Takahashi, Mamoru Ito, Takeshi Takahashi, Mika Yagoto, Asami Hanazawa, Ryoji Ito, Ikumi Katano, Tomoyuki Ogura
Publikováno v:
Biochemical and Biophysical Research Communications. 516:480-485
Although Th17 cells are closely linked to cutaneous graft-versus-host-disease (GVHD) in mouse models, this association remains unclear in human GVHD. In this study, we established a novel xenogeneic cutaneous GVHD model using humanized mice. To induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b9e4e9c5612caa031362d9d6d6f12a
https://doi.org/10.1016/j.bbrc.2019.06.094
https://doi.org/10.1016/j.bbrc.2019.06.094
Autor:
Takahiro Kagawa, Motohito Goto, Kenji Kawai, Takeshi Takahashi, Ryoji Ito, Iyo Otsuka, Ikumi Katano, Takuya Yamaguchi, Asami Hanazawa, Misa Mochizuki
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer in the clinic. Further discovery of novel drugs or therapeutic protocols that enhance efficacy requires reliable animal models that recapitulate human immune responses to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d9c4a17d4451f5628c0b535e8663ca
https://pubmed.ncbi.nlm.nih.gov/34702924
https://pubmed.ncbi.nlm.nih.gov/34702924
Autor:
Ikumi Katano, Asami Hanazawa, Iyo Otsuka, Takuya Yamaguchi, Misa Mochiduki, Kenji Kawai, Ryoji Ito, Motohito Goto, Takahiro Kagawa, Takeshi Takahashi
Publikováno v:
Cancer Research. 82:6026-6026
Humanized mice with human hematopoietic and immune systems have been frequently used for examining in vivo anti-cancer effects of various drugs, including immune checkpoint inhibitors (ICIs) like anti-PD-1 or anti-CTLA-4 antibodies, yet the reliabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2d9671b18cfe2e5604f40b83687f920
https://doi.org/10.1158/1538-7445.am2022-6026
https://doi.org/10.1158/1538-7445.am2022-6026
Autor:
Ryoji Yagi, Atsushi Morita, Hiroyuki Hosokawa, Miki Kato, Masha V. Poyurovsky, Ikue Sakikawa, Morio Nagira, Tomoaki Tanaka, Toshinori Nakayama, Shinichiro Motohashi, Asami Hanazawa, Kenta Shinoda, Kiyoshi Hirahara, Hiroyuki Tohyama, Yutaka Suzuki, Yuuki Tamaki
Publikováno v:
Proceedings of the National Academy of Sciences. 110:18626-18631
GATA-binding protein 3 (Gata3) controls the differentiation of naive CD4 T cells into T helper 2 (Th2) cells by induction of chromatin remodeling of the Th2 cytokine gene loci, direct transactivation of Il5 and Il13 genes, and inhibition of Ifng. Gat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae6aff70a0b6cc35fd134c010c2010e
https://doi.org/10.1073/pnas.1311100110
https://doi.org/10.1073/pnas.1311100110
Autor:
Heizaburo Yamamoto, Kenzo Muramoto, Hiroyuki Hosokawa, Tomomi Ichikawa, Kiyoshi Hirahara, Tomohisa Iinuma, Koji Hayashizaki, Toshinori Nakayama, Koji Tokoyoda, Asami Hanazawa, Shinichiro Motohashi, Kenta Shinoda, Chiaki Iwamura, Yuzuru Ikehara, Damon J. Tumes, Jungo Kakuta, Yoshitaka Okamoto, Atsushi Onodera, Motoko Y. Kimura
Publikováno v:
Science immunology. 1(3)
Recent decades have witnessed a rapid worldwide increase in chronic inflammatory disorders such as asthma. CD4(+) T helper 2 cells play critical roles in the pathogenesis of allergic airway inflammation, and CD69 expression on activated CD4 T cells i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6a220af645a24afd6faa05a029dbbc
https://pubmed.ncbi.nlm.nih.gov/28783682
https://pubmed.ncbi.nlm.nih.gov/28783682
Autor:
Andreas Radbruch, Christian Männe, William E. Paul, Asami Hanazawa, Jana Sarkander, Shintaro Hojyo, David Zimmel, Max Löhning, Jinfang Zhu, Mathias Mursell, Koji Tokoyoda, Simon Fillatreau
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology, Vol 7 (2016)
During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells. However, it remains uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d5542e2e0ad196e5c949eac51dec8f
Autor:
Toshinori Nakayama, Ko Okumura, Shizue Tani-ichi, Kenta Shinoda, Andreas Radbruch, Takahiro Hara, Koji Tokoyoda, Hideo Yagita, Koji Hayashizaki, Max Löhning, Asami Hanazawa, Koichi Ikuta, Beate Eckes
Publikováno v:
Immunology and cell biology. 91(8)
CD4 T cells play a key role in immunological memory. We have demonstrated that professional memory CD4 T cells reside and rest in the bone marrow (BM). However, the molecular mechanisms of their establishment in the BM and their maintenance remain un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5662145c4a144bfaef52df858eb91da0
https://pubmed.ncbi.nlm.nih.gov/23897120
https://pubmed.ncbi.nlm.nih.gov/23897120
Autor:
Toshinori Nakayama, Chiaki Iwamura, Damon J. Tumes, Koji Tokoyoda, Hiroyuki Hosokawa, Andreas Radbruch, Kenta Shinoda, Haruhiko Koseki, Koji Hayashizaki, Sandra Zehentmeier, Asami Hanazawa
Publikováno v:
Proceedings of the National Academy of Sciences
Memory T-helper (Th) lymphocytes are crucial for the maintenance of acquired immunity to eliminate infectious pathogens. We have previously demonstrated that most memory Th lymphocytes reside and rest on stromal niches of the bone marrow (BM). Little
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f2674a70cf98665525857f24918a30
https://hdl.handle.net/11541.2/132065
https://hdl.handle.net/11541.2/132065