Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Asako Otomo"'
Autor:
Matteo Rossi Sebastiano, Giuseppe Ermondi, Kai Sato, Asako Otomo, Shinji Hadano, Giulia Caron
Publikováno v:
Molecules, Vol 27, Iss 20, p 7063 (2022)
Infantile onset hereditary spastic paralysis (IAHSP) is a rare neurological disease diagnosed in less than 50 children worldwide. It is transmitted with a recessive pattern and originates from mutations of the ALS2 gene, encoding for the protein alsi
Externí odkaz:
https://doaj.org/article/c25b83e04e4043e699a1414a94ff4c8d
Autor:
Masahisa Nozaki, Asako Otomo, Shun Mitsui, Suzuka Ono, Ryohei Shirakawa, YongPing Chen, Yutaro Hama, Kai Sato, XuePing Chen, Toshiyasu Suzuki, Hui-Fang Shang, Shinji Hadano
Publikováno v:
eNeurologicalSci, Vol 22, Iss , Pp 100301- (2021)
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are genetically, pathologically and clinically-related progressive neurodegenerative diseases. Thus far, several SQSTM1 variations have been identified in patients with ALS and FTD
Externí odkaz:
https://doaj.org/article/da9e314e3b97477aaef197375f9e6865
Autor:
Akira Oka, Atsushi Takagi, Etsuko Komiyama, Nagisa Yoshihara, Shuhei Mano, Kazuyoshi Hosomichi, Shingo Suzuki, Yuko Haida, Nami Motosugi, Tomomi Hatanaka, Minoru Kimura, Mahoko Takahashi Ueda, So Nakagawa, Hiromi Miura, Masato Ohtsuka, Masayuki Tanaka, Tomoyoshi Komiyama, Asako Otomo, Shinji Hadano, Tomotaka Mabuchi, Stephan Beck, Hidetoshi Inoko, Shigaku Ikeda
Publikováno v:
EBioMedicine, Vol 57, Iss , Pp 102810- (2020)
ABSTRACT: Background: Alopecia areata (AA) is considered a highly heritable, T-cell-mediated autoimmune disease of the hair follicle. However, no convincing susceptibility gene has yet been pinpointed in the major histocompatibility complex (MHC), a
Externí odkaz:
https://doaj.org/article/7cb874ff2ece4cad90ef4fbd8faaa171
Autor:
Kazuko Fujitani, Asako Otomo, Yuto Nagayama, Taro Tachibana, Rika Kato, Yusuke Kawashima, Yoshio Kodera, Tomoko Kato, Shuji Takada, Kei Tamura, Nobuhiko Takamatsu, Michihiko Ito
Publikováno v:
Genetics and Molecular Biology, Vol 43, Iss 2 (2020)
Abstract The transcription factor DMRT1 (doublesex and mab-3 related transcription factor) has two distinct functions, somatic-cell masculinization and germ-cell development in some vertebrate species, including mouse and the African clawed frog Xeno
Externí odkaz:
https://doaj.org/article/501a9209faca4a77a18987add58d3303
Autor:
Hideki Hayashi, Ting Wang, Masayuki Tanaka, Sanae Ogiwara, Chisa Okada, Masatoshi Ito, Nahoko Fukunishi, Yumi Iida, Ayaka Nakamura, Ayumi Sasaki, Shunji Amano, Kazuhiro Yoshida, Asako Otomo, Masato Ohtsuka, Shinji Hadano
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234180 (2020)
The autophagy-endolysosomal pathway is an evolutionally conserved degradation system that is tightly linked to a wide variety of physiological processes. Dysfunction of this system is associated with many pathological conditions such as cancer, infla
Externí odkaz:
https://doaj.org/article/767051c28519456ab50d9e3404ece691
Autor:
Shun Mitsui, Asako Otomo, Masahisa Nozaki, Suzuka Ono, Kai Sato, Ryohei Shirakawa, Hiroaki Adachi, Masashi Aoki, Gen Sobue, Hui-Fang Shang, Shinji Hadano
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-16 (2018)
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by a selective loss of upper and lower motor neurons. Recent studies have shown that mutations in SQSTM1 are linked to ALS. SQSTM1 encodes SQSTM1/p6
Externí odkaz:
https://doaj.org/article/8580ca713204450288e370952c8766f7
Autor:
Yoshiaki Nakamura, Fumitake Usui, Yusuke Atsumi, Asako Otomo, Ayumi Teshima, Tamao Ono, Kumiko Takeda, Keijiro Nirasawa, Hiroshi Kagami, Takahiro Tagami
Publikováno v:
The Journal of Poultry Science, Vol 46, Iss 2, Pp 127-135 (2009)
The current study aimed to determine the optimal time of busulfan (1,4-butanediol dimethanesulfonate) administration for the preparation of suitable recipient embryos to generate germline chimeras in chickens. We compared two different administration
Externí odkaz:
https://doaj.org/article/363bfb3241334cb184404e454a7996da
Autor:
Kaori Suyama, Masahiko Watanabe, Kou Sakabe, Asako Otomo, Yoshinori Okada, Hayato Terayama, Takeshi Imai, Joji Mochida
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86951 (2014)
Oxidative stress, caused by the over production of reactive oxygen species (ROS), has been shown to contribute to cell damage associated with neurotrauma and neurodegenerative diseases. ROS mediates cell damage either through direct oxidation of lipi
Externí odkaz:
https://doaj.org/article/42e207ccd82b411e9649a46d0e937635
Publikováno v:
Neurology Research International, Vol 2012 (2012)
Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of incurable motor neuron diseases (MNDs) characterized by a selective loss of upper and lower motor neurons in the brain and spinal cord. Most cases of ALS are sporadic, while approximatel
Externí odkaz:
https://doaj.org/article/04df581e45944eb9bc3c4e62c2bd968f
Autor:
Lei Pan, Yasuhiro Yoshii, Asako Otomo, Haruko Ogawa, Yasuo Iwasaki, Hui-Fang Shang, Shinji Hadano
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33409 (2012)
Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of fatal neurodegenerative diseases characterized by a selective loss of motor neurons in the brain and spinal cord. Creation of transgenic mice expressing mutant Cu/Zn superoxide dismutase
Externí odkaz:
https://doaj.org/article/347ecb500f6a4e62a16ac5e5c9d715a7