Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Asako Hitomi"'
Autor:
Shin-ichi Satoh, Masakazu Takayasu, Koh Kawasaki, Ichiro Ikegaki, Asako Hitomi, Kazuo Yano, Masato Shibuya, Toshio Asano
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 1, Pp 92-98 (2012)
We investigated the anti-vasospastic potential of fasudil’s active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage (SAH) and also its effect on hemorheological abnormalities following cerebral ischemia. Chronic cer
Externí odkaz:
https://doaj.org/article/0bd4705d70864104aaa00d673e47e588
Autor:
Ichiro Ikegaki, Koh Kawasaki, Masakazu Takayasu, Toshio Asano, Masato Shibuya, Kazuo Yano, Asako Hitomi, Shin'ichi Satoh
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 1, Pp 92-98 (2012)
We investigated the anti-vasospastic potential of fasudil’s active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage (SAH) and also its effect on hemorheological abnormalities following cerebral ischemia. Chronic cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a74e307387c8b744f6dffef3e3376e
https://doi.org/10.1254/jphs.11075fp
https://doi.org/10.1254/jphs.11075fp
Autor:
Osamu Nakazono, Koh Kawasaki, Asako Hitomi, Mitsunobu Mohri, Ichiro Ikegaki, Masakazu Iwasaki, Toshio Asano, Shin'ichi Satoh
Publikováno v:
Brain Research Bulletin. 81:191-195
We investigated the neuroprotective effects of fasudil's active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, in a rat stroke model in which endothelial damage and subsequent thrombotic occlusion were selectively induced in perforating arteries
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff3764b00cdd1fe3447f3a39ea0686e
https://doi.org/10.1016/j.brainresbull.2009.08.021
https://doi.org/10.1016/j.brainresbull.2009.08.021
Autor:
Asako Hitomi, Steven K. Feske, Koh Kawasaki, Yasuo Sasaki, Galen V. Henderson, Farzaneh A. Sorond, James K. Liao, Toshio Asano, Minoru Seto
Publikováno v:
Brain Research. 1257:89-93
Background Rho-kinase (ROCK) is a downstream effector of Rho GTPase that is known to regulate various pathological processes important to the development of ischemic stroke, such as thrombus formation, inflammation, and vasospasm. Inhibition of ROCK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6727c25c761db6337ff71e255e23691b
https://doi.org/10.1016/j.brainres.2008.12.045
https://doi.org/10.1016/j.brainres.2008.12.045
Autor:
Tamami Yamaguchi, Ichiro Ikegaki, Kazumi Shiraiwa, Hiroaki Shimokawa, Asako Hitomi, T. Asano, S. Satoh, Norihiro Sato
Publikováno v:
European Journal of Pharmacology. 455:169-174
This study was designed to investigate possible effects of the Rho-kinase inhibitor, fasudil, on the progression of renal failure in rats with unilateral ureteral obstruction. The renal failure markers monitored were the extent of renal interstitial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd2075b4f83b2144c8e68ecba1b88fe
https://doi.org/10.1016/s0014-2999(02)02619-5
https://doi.org/10.1016/s0014-2999(02)02619-5
Publikováno v:
Brain research bulletin. 84(2)
The aim of this study was to investigate the possible effects of the Rho-kinase inhibitor, fasudil, on the lysophosphatidic acid (LPA)-induced neurite retraction in N1E-115 cells. In cultured N1E-115 cells, LPA produced a marked increase in the popul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695e7c91f6130c13b091b0dc4a2df917
https://pubmed.ncbi.nlm.nih.gov/21126559
https://pubmed.ncbi.nlm.nih.gov/21126559
Publikováno v:
Brain research. 1193
The aim of this study was to investigate the influence of delayed Rho-kinase inhibition with fasudil on second ischemic injury in a rat cerebral thrombosis model. Cerebral ischemia was induced in rats by injecting 150 mug of sodium laurate into the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99694f9601dc898df7ad31e200061be3
https://pubmed.ncbi.nlm.nih.gov/18187127
https://pubmed.ncbi.nlm.nih.gov/18187127
Publikováno v:
Life sciences. 67(16)
The aim of this study was to investigate the mechanisms of the pathogenesis of hyperviscosity following cerebral ischemia. Focal ischemia was produced by embolic occlusion of the right middle cerebral artery (MCA) in rats for 1 hour, followed by reci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696b9066c3786ea3e2b4766490e3914b
https://pubmed.ncbi.nlm.nih.gov/11072869
https://pubmed.ncbi.nlm.nih.gov/11072869
Autor:
Shin'ichi Satoh, Asako Hitomi, Toshio Asano, Teruki Kobayashi, Masato Shibuya, Jun Yoshida, Ichiro Ikegaki, Yoshio Suzuki
Publikováno v:
Japanese journal of pharmacology. 80(1)
This study investigated the therapeutic potential of agents that inhibited neutrophil infiltration in cerebral ischemic infarction. The migration of neutrophils elicited by N-formyl-methionyl-leucyl-phenylalanine, tumor necrosis factor, C5a or platel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931582c02eb26afe25f95d0425ae7b75
https://pubmed.ncbi.nlm.nih.gov/10446755
https://pubmed.ncbi.nlm.nih.gov/10446755
Publikováno v:
Japanese Journal of Pharmacology. 79:194
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::471bb48a5605bca26484822d466d1e80
https://doi.org/10.1016/s0021-5198(19)34791-2
https://doi.org/10.1016/s0021-5198(19)34791-2