Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Asako, McCloskey"'
Autor:
Abhinav Soni, Diana Klütsch, Xin Hu, Judith Houtman, Nicole Rund, Asako McCloskey, Jerome Mertens, Simon T. Schafer, Hayder Amin, Tomohisa Toda
Publikováno v:
Cells, Vol 10, Iss 8, p 1894 (2021)
Neuronal culture was used to investigate neuronal function in physiological and pathological conditions. Despite its inevitability, primary neuronal culture remained a gold standard method that requires laborious preparation, intensive training, and
Externí odkaz:
https://doaj.org/article/a259c185523a443386c5f3071be2580b
Autor:
Alison E. Smith, Stacia Chan, Zhiyong Wang, Asako McCloskey, Quinn Reilly, Jayden Z. Wang, Hetika Vora Patel, Keiichi Koshizuka, Harris S. Soifer, Linda Kessler, Ashley Dayoub, Victoria Villaflor, Douglas Adkins, Justine Bruce, Alan Ho, Cesar Perez Batista, Glenn Hanna, Amaya Gascó Hernández, Andrew Saunders, Stephen Dale, J. Silvio Gutkind, Francis Burrows, Shivani Malik
Outcomes for patients with recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) are poor, with median overall survival ranging from 6 to 18 months. For those who progress on standard of care (chemo)immunotherapy, treatment options
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09c5b042d1929c72d38919e6e5354710
https://doi.org/10.1101/2023.01.17.523964
https://doi.org/10.1101/2023.01.17.523964
The RNA transport factor PHAX is required for proper histone H2AX expression and DNA damage response
Publikováno v:
RNA
PHAX (phosphorylated adaptor for RNA export) promotes nuclear export of short transcripts of RNA polymerase II such as spliceosomal U snRNA precursors, as well as intranuclear transport of small nucleolar RNAs (snoRNAs). However, it remains unknown w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8425b08f32e7e33db7fedfa8d9cf1ad
https://doi.org/10.1261/rna.074625.120
https://doi.org/10.1261/rna.074625.120
Autor:
Shivani Malik, Alison Smith, Stacia Chan, Asako McCloskey, Hetika Vora, Quinn Reilly, Francis Burrows
Publikováno v:
Cancer Research. 82:1120-1120
The PI3K-AKT-mTOR signaling cascade is the most frequently activated pathway in the head and neck squamous cell carcinomas (HNSCC). PIK3CA (encoding PI3K’s α catalytic subunit), is activated by gain-of-function mutation or amplification in approxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d88e4c376190d8d7f2779449946a9e6
https://doi.org/10.1158/1538-7445.am2022-1120
https://doi.org/10.1158/1538-7445.am2022-1120
Publikováno v:
Genes & Development. 32:1321-1331
The total number of nuclear pore complexes (NPCs) per nucleus varies greatly between different cell types and is known to change during cell differentiation and cell transformation. However, the underlying mechanisms that control how many nuclear tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71e4ee1f8c5a0f59c3cc7535b1a4d22
https://doi.org/10.1101/gad.315523.118
https://doi.org/10.1101/gad.315523.118
Abstract P123: Antitumor activity of tipifarnib and PI3K pathway inhibitors in HRAS-associated HNSCC
Autor:
Francis Burrows, Shivani Malik, Stacia Chan, Asako Mccloskey, Zhiyong Wang, Mara Gilard, Silvio Gutkind
Publikováno v:
Molecular Cancer Therapeutics. 20:P123-P123
HRAS-MAPK and PI3K-AKT-mTOR are important oncogenic pathways in head and neck squamous cell carcinoma (HNSCC) and other squamous cell carcinomas (SCCs). HRAS is mutated in ~5% and overexpressed in approximately 30% of HNSCC patients, raising the poss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07435b47b0f0af2e47031659ddb04b15
https://doi.org/10.1158/1535-7163.targ-21-p123
https://doi.org/10.1158/1535-7163.targ-21-p123
Autor:
Martin W. Hetzer, Asako McCloskey, Annie Rathore, Tobias M. Franks, Christopher Benner, Maxim Nikolaievich Shokirev
Publikováno v:
Genes & Development. 31:2222-2234
Recent studies have shown that a subset of nucleoporins (Nups) can detach from the nuclear pore complex and move into the nuclear interior to regulate transcription. One such dynamic Nup, called Nup98, has been implicated in gene activation in health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d2b58e9bff126f546dc8d8647c45079
https://doi.org/10.1101/gad.306753.117
https://doi.org/10.1101/gad.306753.117
Publikováno v:
Nucleic Acids Research
The assembly of spliceosomal U snRNPs in metazoans requires nuclear export of U snRNA precursors. Four factors, nuclear cap-binding complex (CBC), phosphorylated adaptor for RNA export (PHAX), the export receptor CRM1 and RanGTP, gather at the m7G-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e484d3c6d077c004c1828d1d490acf
http://hdl.handle.net/2433/187373
http://hdl.handle.net/2433/187373
Publikováno v:
Genes to Cells. 16:1035-1049
Intron-containing pre-mRNAs are retained in the nucleus until they are spliced. This mechanism is essential for proper gene expression. Although the formation of splicing complexes on pre-mRNAs is thought to be responsible for this nuclear retention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77861c799f24629a3f5e39a3690a26c3
https://doi.org/10.1111/j.1365-2443.2011.01548.x
https://doi.org/10.1111/j.1365-2443.2011.01548.x
Publikováno v:
Methods in cell biology. 122
In eukaryotes, many RNA species are transcribed, processed in the nucleus, and exported to the cytoplasm, where they are destined to function or to be further matured. Some RNAs are even reimported to the nucleus. In addition, many RNAs are localized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0b15840cc8681576c076cffb2cacb25
https://pubmed.ncbi.nlm.nih.gov/24857740
https://pubmed.ncbi.nlm.nih.gov/24857740