Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Asaf Hellman"'
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-32 (2023)
Abstract Background Common diseases manifest differentially between patients, but the genetic origin of this variation remains unclear. To explore possible involvement of gene transcriptional-variation, we produce a DNA methylation-oriented, driver-g
Externí odkaz:
https://doaj.org/article/ef509bc1eb494990b9f0e8f6fed3f9a6
Autor:
Dvir Aran, Monther Abu-Remaileh, Revital Levy, Nurit Meron, Gidon Toperoff, Yifat Edrei, Yehudit Bergman, Asaf Hellman
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005840 (2016)
Cancers often display gene expression profiles resembling those of undifferentiated cells. The mechanisms controlling these expression programs have yet to be identified. Exploring transcriptional enhancers throughout hematopoietic cell development a
Externí odkaz:
https://doaj.org/article/ae109088c83b4545a64ee35e843c0339
Cancers arise when particular disease-driving genes adopt abnormal functions, but analyses of coding and regulatory sequences leave many of these abnormalities unexplained. We developed a strategy to explore alternations in the regulatory effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9f3fca59bd758ce9f7a4b3345ab4e02
https://doi.org/10.1101/2021.03.02.433521
https://doi.org/10.1101/2021.03.02.433521
Autor:
Asaf Hellman, Dvir Aran
Publikováno v:
BioEssays. 36:184-190
Paradoxically, DNA sequence polymorphisms in cancer risk loci rarely correlate with the expression of cancer genes. Therefore, the molecular mechanism underlying an individual's susceptibility to cancer has remained largely unknown. However, recent e
Publikováno v:
Human Molecular Genetics. 20:670-680
Understanding how the epigenetic blueprint of the genome shapes human phenotypes requires systematic evaluation of the complex interplay between gene activity and the different layers of the epigenome. Utilizing microarray-based techniques, we explor
Autor:
Yifat Edrei, Monther Abu-Remaileh, Yehudit Bergman, Nurit Meron, Asaf Hellman, Revital Levy, Dvir Aran, Gidon Toperoff
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 2, p e1005840 (2016)
PLoS Genetics, Vol 12, Iss 2, p e1005840 (2016)
Cancers often display gene expression profiles resembling those of undifferentiated cells. The mechanisms controlling these expression programs have yet to be identified. Exploring transcriptional enhancers throughout hematopoietic cell development a
Autor:
Wiessam Abu Ahmad, Jeremy D. Kark, Dvir Aran, Asaf Hellman, Benjamin Glaser, Dima Azaiza, Hisham Nassar, Ronit Sinnreich, Gidon Toperoff
Publikováno v:
Clinical Epigenetics
Background Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North African Arab populations, but the molecular basis for this susceptibility is unknown. Altered DNA methylation levels were reported in insulin-secreting and resp
Autor:
Asaf Hellman, Dvir Aran
Publikováno v:
Cell. 154:11-13
Predisposition to common human diseases is frequently associated with polymorphisms in distal control regions, also known as gene enhancers. Li et al. (Li et al., 2013) evaluated the relative contributions of somatic and germline mutations to intertu
Autor:
Michael Brandeis, Shay Rotkopf, Andrew C.G. Porter, Asaf Hellman, Yosef Gruenbaum, Ayelet Laronne
Publikováno v:
Molecular Biology of the Cell. 14:3730-3740
Human HT2-19 cells with a conditional cdk1 mutation stop dividing upon cdk1 inactivation and undergo multiple rounds of endoreplication. We show herein that major cell cycle events remain synchronized in these endoreplicating cells. DNA replication a
Autor:
Eytan Domany, Sylvia Wilder, Giovanni Blandino, F Biagoni, D Azaiza, S Adi Harel, Gilad Fuchs, Yael Aylon, N. Bossel Ben-Moshe, Moshe Oren, Neta Moskovits, Debora Rosa Bublik, Asaf Hellman, Gidon Toperoff
Publikováno v:
Cell death and differentiation. 22(8)
MicroRNAs (miRs) regulate a varietyof cellular processes, and their impaired expression is involved in cancer. Silencing of tumorsuppressivemiRs incancercanoccur throughepigenetic modifications, includingDNAmethylation andhistone deacetylation. We pe