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Autor:
Iskra Pusic, Steven Z. Pavletic, John P. Galvin, Amandeep Salhotra, Zhongming Yang, Dianna S. Howard, Madan Jagasia, Ayman Saad, Wanxing Chai-Ho, Bruce R. Blazar, Aaron C Logan, Amelia Langston, Corey Cutler, Trent P Wang, Jonathan Ieyoub, Sally Arai, Marcello Rotta, Mukta Arora, Jane L. Liesveld, Asaf Alavi, David Eiznhamer, Mark B. Juckett, Annie Im, Aravind Ramakrishnan, Behyar Zoghi, Sunil Abhyankar, John J. Ryan, Nirav N. Shah, Stephanie J. Lee, Laurie S. Green, Zachariah DeFilipp, Heidi Krenz, Rohtesh S. Mehta, Harlan Waksal, Sanjay K. Aggarwal, Carlos R. Bachier, Levanto Schachter, Aleksandr Lazaryan, Olivier Schueller
Publikováno v:
Blood
Introduction: Belumosudil (KD025) is a novel oral selective rho-associated coiled-coil kinase 2 (ROCK2) inhibitor specifically designed for the treatment of cGVHD, an immune-mediated inflammatory and fibrotic disorder. In a previous dose-finding stud