Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Asael Roichman"'
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The modern lifestyle requires less physical activity and skills during our daily routine, leading to multiple pathologies related to physical disabilities and energy accessibility. Thus, exploring the mechanisms underlying the metabolic regulation of
Externí odkaz:
https://doaj.org/article/e797fbe09ee54296bc603a02bf228e1f
Autor:
Shoshana Naiman, Frank K. Huynh, Reuven Gil, Yair Glick, Yael Shahar, Noga Touitou, Liat Nahum, Matan Y. Avivi, Asael Roichman, Yariv Kanfi, Asaf A. Gertler, Tirza Doniger, Olga R. Ilkayeva, Ifat Abramovich, Orly Yaron, Batia Lerrer, Eyal Gottlieb, Robert A. Harris, Doron Gerber, Matthew D. Hirschey, Haim Y. Cohen
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 4127-4143.e8 (2019)
Summary: The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling, known to regulate multiple metabolic pathways. SIRT6 binds PPARα a
Externí odkaz:
https://doaj.org/article/d5de3d9672bd4669986a28b46e0384ff
Autor:
Yaeli Lev-Vachnish, Sharon Cadury, Aviva Rotter-Maskowitz, Noa Feldman, Asael Roichman, Tomer Illouz, Alexander Varvak, Raneen Nicola, Ravit Madar, Eitan Okun
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Neurogenesis, the formation of new neurons in the adult brain, is important for memory formation and extinction. One of the most studied external interventions that affect the rate of adult neurogenesis is physical exercise. Physical exercise promote
Externí odkaz:
https://doaj.org/article/33ffe6f24663492daff530c79be5dc3d
Autor:
Moshe Kafri, Weronika Patena, Lance Martin, Lianyong Wang, Gillian Gomer, Arthur K Sirkejyan, Audrey Goh, Alexandra T. Wilson, Sophia E Gavrilenko, Michal Breker, Asael Roichman, Claire D. McWhite, Joshua D. Rabinowitz, Frederick R Cross, Martin Wühr, Martin C. Jonikas
SUMMARYPhotosynthesis is central to food production and the Earth’s biogeochemistry, yet the molecular basis for its regulation remains poorly understood. Here, using high-throughput genetics in the model eukaryotic algaChlamydomonas reinhardtii, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24e78cc922425ab981fb0a866929793d
https://doi.org/10.1101/2022.11.12.515357
https://doi.org/10.1101/2022.11.12.515357
Autor:
Sivan Elhanati, Yariv Kanfi, Alexander Varvak, Asael Roichman, Ilana Carmel-Gross, Shaul Barth, Gilad Gibor, Haim Y. Cohen
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 905-912 (2013)
The NAD+-dependent protein deacetylase SIRT6 regulates genome stability, cancer, and lifespan. Mice overexpressing SIRT6 (MOSES) have lower low-density lipoprotein cholesterol levels and are protected against the physiological damage of obesity. Here
Externí odkaz:
https://doaj.org/article/40ec652d95a4433f8056d09c69c5ae2b
Autor:
Xianfeng Zeng, Xi Xing, Meera Gupta, Felix C Keber, Jaime G Lopez, Asael Roichman, Lin Wang, Michael D Neinast, Mohamed S Donia, Martin Wühr, Cholsoon Jang, Joshua D Rabinowitz
Great progress has been made in understanding gut microbiome’s products and their effects on health and disease. Less attention, however, has been given to the inputs that gut bacteria consume. Here we quantitatively examine inputs and outputs of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::532458ac7ffa0a128104f80c087f5d50
https://doi.org/10.1101/2022.01.25.477736
https://doi.org/10.1101/2022.01.25.477736
Autor:
Ifat Abramovich, Doron Gerber, Matthew D. Hirschey, Olga Ilkayeva, Yael Shahar, Asaf A. Gertler, Asael Roichman, Yair Glick, Noga Touitou, Haim Y. Cohen, Orly Yaron, Matan Y. Avivi, Liat Nahum, Robert A. Harris, Frank K. Huynh, Reuven Gil, Yariv Kanfi, Eyal Gottlieb, Shoshana Naiman, Batia Lerrer, Tirza Doniger
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 4127-4143.e8 (2019)
Summary: The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling, known to regulate multiple metabolic pathways. SIRT6 binds PPARα a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a0fdd89fedfd6c7785ea89d63a1ca0
http://www.sciencedirect.com/science/article/pii/S221112471931558X
http://www.sciencedirect.com/science/article/pii/S221112471931558X
Autor:
Haim Y. Cohen, A. Di Francesco, Orly Yaron, Alexey E. Lyashkov, Yael Shahar, I. Lebenthal-Loinger, Batya Lerrer, Asael Roichman, Miguel A. Aon, Matan Y. Avivi, Sivan Elhanati, Pablo J. Fernandez-Marcos, Yariv Kanfi, Ceereena Ubaida-Mohien, A. Shuchami, Ifat Abramovich, Manuel Serrano, Z. Petrover, R. de Cabo, Eyal Gottlieb, M. Shurgi, Y. Wiesner, A. Rubinstein
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The NAD+-dependent SIRT6 deacylase regulates aging and metabolism through mechanisms that largely remain unknown. Here, we show that SIRT6 overexpression leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6def2446946f4ce3fd3c05338acece95
https://doi.org/10.1038/s41467-021-23545-7
https://doi.org/10.1038/s41467-021-23545-7
Autor:
Susanne Holtze, Eva Leman, Lital Sharvit, Asael Roichman, Irena Manov, Haim Y. Cohen, Gil Atzmon, Huda Adwan Shekhidem, Imad Shams, Thomas B. Hildebrandt, Derek M. Huffman
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 13
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3233 (2019)
International journal of molecular sciences, 20(13):3233
Volume 20
Issue 13
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3233 (2019)
International journal of molecular sciences, 20(13):3233
Telomere dynamics have been found to be better predictors of survival and mortality than chronological age. Telomeres, the caps that protect the end of linear chromosomes, are known to shorten with age, inducing cell senescence and aging. Furthermore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203fbafcafb67445e3f5aaf5936ff249
Autor:
Andrei Seluanov, Valeria Kogan, Michael Van Meter, Vera Gorbunova, Zhonghe Ke, Raul S. Gonzalez, Andrei V. Gudkov, Marina P. Antoch, Margarita Meer, Matthew Simon, Haim Y. Cohen, Stephen L. Helfand, Asael Roichman, Vadim N. Gladyshev, Nicola Neretti, Katerina I. Leonova, Marco De Cecco, John M. Sedivy, Taketo Taguchi, Julia Ablaeva
Summary Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly elevated LINE1 (L1) activity. Here we report that SIRT6-deficient cells and tissues accumulate abundant cytoplasmic L1 cDNA, which triggers strong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9cd2051456cb6d0b6662d4fe83bf2e
https://europepmc.org/articles/PMC6449196/
https://europepmc.org/articles/PMC6449196/