Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Asa Karlstrom"'
Autor:
Rebecca Epperly, Emilia M. Pinto, Teresa Santiago, Heather Sheppard, Michael R. Clay, Christopher Morton, Phuong Nguyen, Yinmei Zhou, Mary Woolard, Carla O'Reilly, Julie Justice, Walter Akers, Melissa Johnson, Asa Karlstrom, Cheng Cheng, Gerard Zambetti, Andrew Davidoff, Raul Ribeiro, Christopher DeRenzo
Publikováno v:
Cancer Research. 83:1197-1197
Outcomes for pediatric patients with unresectable, metastatic, or relapsed adrenocortical carcinoma (ACC) are dismal despite aggressive management with multimodality therapies. CAR T cell therapy (CAR T) is a promising approach to improve outcomes fo
Autor:
Yanay Rosen, Timothy L. Tickle, Joshua Gould, Satyen H. Gohil, Danielle Dionne, Natalie B. Collins, Gabriela Smith-Rosario, Orr Ashenberg, Michal Slyper, Johanna Klughammer, Avinash Waghray, Julia Waldman, F. Stephen Hodi, Anand G. Patel, Catherine J. Wu, Sébastien Vigneau, Simon Gritsch, Masashi Nomura, Eugene Drokhlyansky, Suzanne J. Baker, Sara Napolitano, Isaac Wakiro, Mario L. Suvà, Caroline B. M. Porter, Aviv Regev, Nikhil Wagle, Jingyi Wu, Ursula A. Matulonis, Elizabeth H. Stover, Michael A. Dyer, Orit Rozenblatt-Rosen, Charles H. Yoon, Aaron N. Hata, Asa Karlstrom, Bruce E. Johnson, Rizwan Haq, Bo Li, Christopher Smillie, Matan Hofree, Michael R. Clay, Lan Nguyen, Raphael Bueno, Judit Jané-Valbuena, Alexander M. Tsankov, Benjamin Izar, Peter J. Tramontozzi, Ofir Cohen, Livnat Jerby-Arnon, Mei-Ju Su, Asaf Rotem
Publikováno v:
Nature Medicine
Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-dissociate tumors.
Autor:
Heather Tillman, Kaley Blankenship, Dominik Wodarz, Matthew J. Krasin, Michael A. Dyer, Natalia L. Komarova, Colleen Reilly, Xin Zhou, Alberto S. Pappo, Brent A. Orr, Jiyang Yu, Anand G. Patel, Jackie L. Norrie, Elizabeth Stewart, Xiang Chen, Clay Mr, Brittney Gordon, Justina McEvoy, Huang X, Asa Karlstrom
Publikováno v:
Dev Cell
Rhabdomyosarcoma (RMS) is a pediatric cancer with features of skeletal muscle; patients with unresectable or metastatic RMS fare poorly due to high rates of disease recurrence. Here, we use single cell and single nucleus RNA-sequencing to show that R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a225aa80c4a8962cc77b58ade316c2b9
https://doi.org/10.1101/2021.06.16.448386
https://doi.org/10.1101/2021.06.16.448386
This protocol was used for the dissociation of fresh pediatric neuroblastoma samples from patient tumors or orthotopic patient derived xenografts. Using this method, we were able to prepare highly viable (>90%) single-cell suspensions compatible with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc037dab7bc822c296d611bb99af3bd
https://doi.org/10.17504/protocols.io.98ah9se
https://doi.org/10.17504/protocols.io.98ah9se
Autor:
Cori Bradley, Jason Dapper, Xin Zhou, Jianrong Wu, Armita Bahrami, James R. Downing, Sara M. Federico, Elizabeth Stewart, Asa Karlstrom, Alberto S. Pappo, Nathaniel R. Twarog, Kaley Blankenship, Anang A. Shelat, Jinghui Zhang, Burgess B. Freeman, Victoria Honnell, Richard K. Wilson, Monica Ocarz, John Easton, Beisi Xu, Brittney Gordon, Michael A. Dyer, Xiang Chen, Elaine R. Mardis, Michael R. Clay
Publikováno v:
Nature
Paediatric solid tumours arise from endodermal, ectodermal, or mesodermal lineages. Although the overall survival of children with solid tumours is 75%, that of children with recurrent disease is below 30%. To capture the complexity and diversity of
Autor:
Gabriela Smith-Rosario, Ofir Cohen, Masashi Nomura, Sara Napolitano, Caroline B. M. Porter, Suzanne J. Baker, Michael A. Dyer, Aviv Regev, Lan Nguyen, Orit Rozenblatt-Rosen, Charles H. Yoon, Danielle Dionne, Sébastien Vigneau, Bruce E. Johnson, Livnat Jerby-Arnon, Rizwan Haq, Mario L. Suvà, Julia Waldman, Catherine J. Wu, Raphael Bueno, Anand G. Patel, Judit Jané-Valbuena, Natalie B. Collins, Satyen H. Gohil, Alexander M. Tsankov, Joshua Gould, Johanna Klughammer, Orr Ashenberg, Simon Gritsch, Bo Li, Christopher Smillie, Benjamin Izar, Yanay Rosen, Nikhil Wagle, Elizabeth H. Stover, Michael R. Clay, Michal Slyper, Jingyi Wu, Ursula A. Matulonis, Asa Karlstrom, F. Stephen Hodi, Aaron N. Hata, Avinash Waghray, Eugene Drokhlyansky, Isaac Wakiro, Asaf Rotem, Mei-Ju Su
Single cell genomics is essential to chart the complex tumor ecosystem. While single cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumor tissues, single nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-diss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8052f952feff5391c6f82911b18a5835
Autor:
Asa Karlstrom, Anang A. Shelat, Sara M. Federico, Alberto S. Pappo, Andras Sablauer, Elizabeth Stewart, Michael A. Dyer
Publikováno v:
Developmental Biology. 411(2):287-293
Significant advances have been made over the past 25 years in our understanding of the most common adult solid tumors such as breast, colon, lung and prostate cancer. Much less is known about childhood solid tumors because they are rare and because t
Autor:
Brittney Gordon, Anand G. Patel, Michael R. Clay, Elizabeth J. Stewart, Xiang Chen, Michael A. Dyer, Jim Houston, Asa Karlstrom, Jackie L. Norrie
Publikováno v:
Cancer Research. 80:6155-6155
Rhabdomyosarcoma (RMS), is a pediatric tumor that histologically mimics developing skeletal muscle. Importantly, RMS tumors feature heterogeneous expression of the skeletal muscle transcription factor myogenin (MYOG). However, the degree by which RMS
Autor:
Xin Zhou, Cynthia Williams, Edgar Sioson, Nathaniel R. Twarog, Asa Karlstrom, Darrell T. Gentry, Clay McLeod, Swapnali Mohite, Ti-Cheng Chang, Gang Wu, Ed Suh, Alberto S. Pappo, Brandon McMahan, Brittney Gordon, Sharon Frase, Ashok K. Boddu, Armita Bahrami, Michael Rusch, Elizabeth J. Stewart, Irina McGuire, Kirby Birch, Rachel C. Brennan, Sara M. Federico, Xiang Chen, Anthony Woodard, Daniel Alford, Nedra Robison, Anang A. Shelat, Michael A. Dyer, Keith Perry, Michael R. Clay
Publikováno v:
Cancer Research. 80:6149-6149
Despite making significant advances over the past 25 years in our understanding of the most common adult solid tumors, much less is known about childhood solid tumors. We have previously described a protocol to produce orthotopic patient-derived xeno
Autor:
Aviv Regev, Nikhil Wagle, F. Stephen Hodi, Elizabeth H. Stover, Sébastien Vigneau, Timothy L. Tickle, Caroline B. M. Porter, Mario L. Suvà, Matan Hofree, Yanay Rosen, Michael A. Dyer, Judit Jané-Valbuena, Charles H. Yoon, Sara Napolitano, Bruce E. Johnson, Lan Nguyen, Jingyi Wu, Gabriela Smith-Rosario, Michal Slyper, Bo Li, Alexander M. Tsankov, Julia Waldman, Christopher Smillie, Orit Rozenblatt-Rosen, Anand G. Patel, Catherine J. Wu, Masashi Nomura, Michael R. Clay, Rizwan Haq, Avinash Waghray, Raphael Bueno, Asa Karlstrom, Asaf Rotem, Eugene Drokhlyansky, Isaac Wakiro, Simon Gritsch, Aaron N. Hata, Ursula A. Matulonis, Danielle Dionne, Mei-Ju Su, Satyen H. Gohil, Orr Ashenberg, Johanna Klughammer, Natalie B. Collins, Suzanne J. Baker, Livnat Jerby-Arnon, Joshua Gould, Ofir Cohen, Benjamin Izar, Peter J. Tramontozzi
Publikováno v:
Nature Medicine
Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-dissociate tumors.