Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Asa A Brockman"'
Autor:
Nalin Leelatian, Justine Sinnaeve, Akshitkumar M Mistry, Sierra M Barone, Asa A Brockman, Kirsten E Diggins, Allison R Greenplate, Kyle D Weaver, Reid C Thompson, Lola B Chambless, Bret C Mobley, Rebecca A Ihrie, Jonathan M Irish
Publikováno v:
eLife, Vol 9 (2020)
A goal of cancer research is to reveal cell subsets linked to continuous clinical outcomes to generate new therapeutic and biomarker hypotheses. We introduce a machine learning algorithm, Risk Assessment Population IDentification (RAPID), that is uns
Externí odkaz:
https://doaj.org/article/4b0f2febcca2420290d9f64856a5a58a
Autor:
Todd Bartkowiak, Sierra M. Lima, Madeline J. Hayes, Akshitkumar M. Mistry, Asa A. Brockman, Justine Sinnaeve, Nalin Leelatian, Caroline E. Roe, Bret C. Mobley, Silky Chotai, Kyle D. Weaver, Reid C. Thompson, Lola B. Chambless, Rebecca A. Ihrie, Jonathan M. Irish
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Radiographic contact of glioblastoma (GBM) tumors with the lateral ventricle and adjacent stem cell niche correlates with poor patient prognosis, but the cellular basis of this difference is unclear. Here, we reveal and functionally characterize dist
Externí odkaz:
https://doaj.org/article/29907ada4aa143a69143033c5dcfd8c4
Autor:
Rebecca J. Embalabala, Asa A. Brockman, Amanda R. Jurewicz, Jennifer A. Kong, Kaitlyn Ryan, Cristina D. Guinto, Arturo Álvarez-Buylla, Chin Chiang, Rebecca A. Ihrie
Publikováno v:
Cells, Vol 11, Iss 2, p 218 (2022)
The ventricular–subventricular zone (V-SVZ) is a postnatal germinal niche. It holds a large population of neural stem cells (NSCs) that generate neurons and oligodendrocytes for the olfactory bulb and (primarily) the corpus callosum, respectively.
Externí odkaz:
https://doaj.org/article/a0ae46c327a44206b07e0cfd7199e004
Autor:
Vivianne E. Morrison, Matthew G. Houpert, Jonathan B. Trapani, Asa A. Brockman, Philip J. Kingsley, Ketaki A. Katdare, Hillary M. Layden, Gabriela Nguena-Jones, Alexandra J. Trevisan, Kathleen A. Maguire-Zeiss, Lawrence J. Marnett, Gregory J. Bixa, Rebecca A. Ihrie, Bruce D. Carter
Microglia are the primary phagocytes in the central nervous system and are responsible for clearing dead cells generated during development or disease. The phagocytic process shapes the phenotype of the microglia, which affects the local environment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3baf45fb2a4d1793a40a8c7ca21af12f
https://doi.org/10.1101/2023.03.03.531012
https://doi.org/10.1101/2023.03.03.531012
Autor:
Laura C. Geben, Asa A. Brockman, Mary Bronwen L. Chalkley, Serena R. Sweet, Julia E. Gallagher, Alexandra L. Scheuing, Richard B. Simerly, Kevin C. Ess, Jonathan M. Irish, Rebecca A. Ihrie
Publikováno v:
bioRxiv
A limiting factor in the regenerative capacity of the adult brain is the abundance and proliferative ability of neural stem cells (NSCs). Adult NSCs are derived from a subpopulation of embryonic NSCs that temporarily enter quiescence during mid-gesta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3198b90449be7eb2cf47c3dcc1efda3
https://europepmc.org/articles/PMC9948964/
https://europepmc.org/articles/PMC9948964/
Autor:
Asa A. Brockman, Rohit Khurana, Todd Bartkowiak, Portia L. Thomas, Shamilene Sivagnanam, Courtney B. Betts, Lisa M. Coussens, Christine M. Lovly, Jonathan M. Irish, Rebecca A. Ihrie
Publikováno v:
Cytometry Part B: Clinical Cytometry.
Cyclic immunohistochemistry (cycIHC) uses sequential rounds of colorimetric immunostaining and imaging for quantitative mapping of location and number of cells of interest. In addition, cycIHC benefits from the speed and simplicity of brightfield mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472aae633fa94e858832d85e7f522555
https://doi.org/10.1002/cyto.b.22114
https://doi.org/10.1002/cyto.b.22114
Autor:
Shoaib Ajaib, Disha Lodha, Steven Pollock, Gemma Hemmings, Martina A. Finetti, Arief Gusnanto, Aruna Chakrabarty, Azzam Ismail, Erica Wilson, Frederick S Varn, Bethany Hunter, Andrew Filby, Asa A. Brockman, David McDonald, Roel GW Verhaak, Rebecca A. Ihrie, Lucy F. Stead
Publikováno v:
Neuro-Oncology.
The biological and clinical impact of neoplastic and immune cell type ratios in the glioblastoma (GBM) tumour microenvironment is being realised. Characterising and quantifying cell types within GBMs at scale will facilitate a better understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc48c1927d253202ef85cf3f0cdc163
https://doi.org/10.1093/neuonc/noad021
https://doi.org/10.1093/neuonc/noad021
Autor:
Lola B. Chambless, Akshitkumar M. Mistry, Caroline E. Roe, Bret C. Mobley, Reid C. Thompson, Asa A. Brockman, Allison R. Greenplate, Jonathan M. Irish, Justine Sinnaeve, Madeline Hayes, Todd Bartkowiak, Nalin Leelatian, Rebecca A. Ihrie, Kyle D. Weaver, Sierra Barone
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundGlioblastomas (GBM) account for 60% of adult primary brain tumors. With few advances in therapeutics, median overall survival remains 15-months post-diagnosis. Immunotherapies may provide therapeutic benefit in GBM patients; however, no pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3589e0ae0a47260f08d8db9ce3c25011
https://doaj.org/article/ed3830b4d7f5480caf02ab6415ad6f00
https://doaj.org/article/ed3830b4d7f5480caf02ab6415ad6f00
Publikováno v:
J Histochem Cytochem
The neural stem cell niche of the ventricular–subventricular zone supports the persistence of stem and progenitor cells in the mature brain. This niche has many notable cytoarchitectural features that affect the activity of stem cells and may also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32eac4e2db51f7dd162bfd75dc921230
https://pubmed.ncbi.nlm.nih.gov/34310246
https://pubmed.ncbi.nlm.nih.gov/34310246
Autor:
Rebecca J. Embalabala, Asa A. Brockman, Amanda R. Jurewicz, Jennifer A. Kong, Kaitlyn Ryan, Cristina D. Guinto, Arturo Álvarez-Buylla, Chin Chiang, Rebecca A. Ihrie
Publikováno v:
Cells
Cells, vol 11, iss 2
Cells, Vol 11, Iss 218, p 218 (2022)
Cells, vol 11, iss 2
Cells, Vol 11, Iss 218, p 218 (2022)
The ventricular–subventricular zone (V-SVZ) is a postnatal germinal niche. It holds a large population of neural stem cells (NSCs) that generate neurons and oligodendrocytes for the olfactory bulb and (primarily) the corpus callosum, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e14f1758196df24e66e34239300704
https://pubmed.ncbi.nlm.nih.gov/35053334
https://pubmed.ncbi.nlm.nih.gov/35053334