Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles.

Autor: Eric P Ratliff, Roxanne W Kotzebue, Brandon Molina, Ruth E Mauntz, Arysa Gonzalez, Ayeh Barekat, Nadja El-Mecharrafie, Shannon Garza, Michael A Gurney, Madhulika Achal, Phyllis-Jean Linton, Greg L Harris, Kim D Finley

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164239 (2016)

The autophagy pathway is critical for the long-term homeostasis of cells and adult organisms and is often activated during periods of stress. Reduced pathway efficacy plays a central role in several progressive neurological disorders that are associa

Externí odkaz: https://doaj.org/article/90935df0fad34007ba2dadd93907a089

Using Drosophila as an integrated model to study mild repetitive traumatic brain injury

Autor: Girish C. Melkani, Brandon Molina, Ayeh Barekat, Catherine J. Conner, Kim D. Finley, William J. Joiner, Arysa Gonzalez, Marta M. Lipinski, Shannon Garza, Ruth E. Mauntz, Roxanne W. Kotzebue, Nadja El-Mecharrafie, Eric P. Ratliff

Publikováno v: Scientific reports, vol 6, iss 1
Barekat, A; Gonzalez, A; Mauntz, RE; Kotzebue, RW; Molina, B; El-Mecharrafie, N; et al.(2016). Using Drosophila as an integrated model to study mild repetitive traumatic brain injury.. Scientific reports, 6, 25252. doi: 10.1038/srep25252. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/26x5b4dh
Scientific Reports

Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. In addition, there has been a growing appreciation that even repetitive, milder forms of TBI (mTBI) can have long-term deleterious consequences to neural tissues. Ham

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945e5536a98166509ceab6158cb3c5be
https://escholarship.org/uc/item/26x5b4dh

Aging and Intermittent Fasting Impact on Transcriptional Regulation and Physiological Responses of Adult Drosophila Neuronal and Muscle Tissues

Autor: Daniel Daugherty, Brandon Molina, Sharon Zhang, Greg L. Harris, Eric P. Ratliff, Robert Edwards, Ruth E. Mauntz, Kim D. Finley, Andrew M Macias, William A Bray, Arysa Gonzalez, Nadja El-Mecharrafie, Madhulika Achal, Ayeh Barekat, Jessica Mastroianni, Roxanne W. Kotzebue

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 4, p 1140 (2018)
International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 1140
International Journal of Molecular Sciences

The progressive decline of the nervous system, including protein aggregate formation, reflects the subtle dysregulation of multiple functional pathways. Our previous work has shown intermittent fasting (IF) enhances longevity, maintains adult behavio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75b3795e908427759c79386cefba689
https://doi.org/10.3390/ijms19041140