Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Aryn Gittis"'
Autor:
Adithya Gopinath, Phillip Mackie, Basil Hashimi, Anna Marie Buchanan, Aidan R. Smith, Rachel Bouchard, Gerry Shaw, Martin Badov, Leila Saadatpour, Aryn Gittis, Adolfo Ramirez-Zamora, Michael S. Okun, Wolfgang J. Streit, Parastoo Hashemi, Habibeh Khoshbouei
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract Parkinson’s disease (PD) is marked by a loss of dopamine neurons, decreased dopamine transporter (DAT) and tyrosine hydroxylase (TH) expression. However, this validation approach cannot be used for diagnostic, drug effectiveness or investi
Externí odkaz:
https://doaj.org/article/1e1f115b1bba4304b630a841b7066a0a
Autor:
Teresa Spix, Aryn Gittis
Publikováno v:
eLife, Vol 9 (2020)
Recording the neural activity of cells in the brain of patients with Parkinson's disease challenges long-standing assumptions about how this disease manifests at the cellular level.
Externí odkaz:
https://doaj.org/article/0c67dadc2f4f4f3094a7aadcc41046fb
To fire at high rates, neurons express ionic currents that work together to minimize refractory periods by ensuring that sodium channels are available for activation shortly after each action potential. Vestibular nucleus neurons operate around high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcae68f8935a64e94a7efc5d1bbdc4e7
Cell-type diversity in the brain enables the assembly of complex neural circuits, whose organization and patterns of activity give rise to brain function. However, the identification of distinct neuronal populations within a given brain region is oft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade9e41fe2314dad6616d7d9996a22bc
Autor:
Aryn, Gittis
Publikováno v:
Science (New York, N.Y.). 338(6103)
Autor:
Aryn Gittis, Kreitzer, Anatol C.
The basal ganglia network serves to integrate information about context, actions, and outcomes to shape the behavior of an animal based on its past experience. Clinically, the basal ganglia receive the most attention for their role in movement disord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cde49585d805a6b4bae680e049537f
Autor:
Aryn Gittis
Imagine one day you notice a tremor and can't walk easily anymore. Your doctor tells you that you have Parkinson's disease and gives you levodopa, a 60-year-old treatment that temporarily relieves your symptoms. But over time, the medication makes yo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e740bba3b0c64805c8eb690b9150416
Autor:
Aryn Gittis, Lac, Sascha Du
Sodium currents in fast firing neurons are tuned to support sustained firing rates >50-60 Hz. This is typically accomplished with fast channel kinetics and the ability to minimize the accumulation of Na channels into inactivated states. Neurons in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e6cba48343e45647e1b6c6f0aa568a
Autor:
Aryn Gittis, Lac, Sascha Du
Neural circuits are composed of diverse cell types, the firing properties of which reflect their intrinsic ionic currents. GABAergic and non-GABAergic neurons in the medial vestibular nuclei, identified in GIN and YFP-16 lines of transgenic mice, res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a31ff85c9934d0c2ff1832ffcc787e