Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Arye Elfenbein"'
Autor:
Deepak Srivastava, Stacia K. Wyman, Ping Zhou, T. Yvanka de Soysa, Arye Elfenbein, Sanjeev S. Ranade, Yen Kim Bui, Casey A. Gifford, Kimberly R. Cordes Metzler, Yu Huang, Ryan Samarakoon, Kathryn N. Ivey, Hazel T. Salunga, Philip C. Ursell
Publikováno v:
Science (New York, N.Y.), vol 364, iss 6443
Three rights can make a wrong Many diseases are thought to arise from co-inheritance of rare genetic variants that are benign on their own but harmful in combination. This hypothesis has been difficult to validate by functional experiments. Gifford e
Autor:
Yen-Sin Ang, Yu Huang, Amy Foley, Tamer M.A. Mohamed, Ethan Radzinsky, Arye Elfenbein, Deepak Srivastava, Ping Zhou, Sergey Magnitsky
Publikováno v:
Cell, vol 173, iss 1
Human diseases are often caused by loss of somatic cells that are incapable of re-entering the cell cycle for regenerative repair. Here, we report a combination of cell-cycle regulators that induce stable cytokinesis in adult post-mitotic cells. We s
Autor:
Arye Elfenbein, Michiyuki Matsuda, Martin A. Schwartz, Julia Meller, Michael Simons, John Rhodes
Publikováno v:
The Journal of Cell Biology
Fibroblast growth factor 2 (FGF2) is a major regulator of developmental, pathological, and therapeutic angiogenesis. Its activity is partially mediated by binding to syndecan 4 (S4), a proteoglycan receptor. Angiogenesis requires polarized activation
Publikováno v:
Journal of Biological Chemistry. 283:29699-29705
Photoreceptor cGMP phosphodiesterase (PDE6) is the central enzyme in the visual transduction cascade. The PDE6 catalytic subunit contains a catalytic domain and regulatory GAF domains. Unlike most GAF domain-containing cyclic nucleotide phosphodieste
Publikováno v:
Cardiovascular Research. 78:223-231
Whereas fibroblast growth factors (FGFs) classically transmit their signals via high-affinity tyrosine kinase receptors (FGFR1-4), recent evidence strongly implicates non-tyrosine kinase receptors (NTKR) or cell-surface FGFR-interacting proteins as i
Autor:
Zhen W. Zhuang, Karen L Moodie, Michael Simons, Peter Carmeliet, Amy Hall, Daniela Tirziu, Lieve Moons, Carmen Roncal, Marc Tjwa, Robert T. Palac, Emmanuel Chorianopoulos, Arye Elfenbein, Qiangwei Fu, Ulf Eriksson
Publikováno v:
Journal of Clinical Investigation. 117:3188-3197
Although studies have suggested a role for angiogenesis in determining heart size during conditions demanding enhanced cardiac performance, the role of EC mass in determining the normal organ size is poorly understood. To explore the relationship bet
Autor:
Arye Elfenbein, Vadim Y. Arshavsky, Andrew Bohm, Kirill A. Martemyanov, Nikolai P. Skiba, William F. Simonds, Johnathan A. Hopp
Publikováno v:
Journal of Biological Chemistry. 276:37365-37372
RGS proteins regulate the duration of G protein signaling by increasing the rate of GTP hydrolysis on G protein alpha subunits. The complex of RGS9 with type 5 G protein beta subunit (G beta 5) is abundant in photoreceptors, where it stimulates the G
Autor:
Michael Simons, Arye Elfenbein
Publikováno v:
Journal of cell science. 126(Pt 17)
Syndecan-4, a ubiquitous cell surface proteoglycan, mediates numerous cellular processes through signaling pathways that affect cellular proliferation, migration, mechanotransduction and endocytosis. These effects are achieved through syndecan-4 func
Autor:
Theresa X. Zhou, Arye Elfenbein, Michiyuki Matsuda, Anthony A. Lanahan, Eugene Tkachenko, Alisa Yamasaki, Michael Simons
Publikováno v:
Science Signaling. 5
Fibroblast growth factor 2 (FGF2) induces endothelial cell migration and angiogenesis through two classes of receptors: receptor tyrosine kinases, such as FGF receptor 1 (FGFR1), and heparan sulfate proteoglycans, such as syndecan 4 (S4). We examined