Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Aryatara Shakya"'
Autor:
Aryatara Shakya, Pengfei Liu, Jack Godek, Nicholas W. McKee, Matthew Dodson, Annadurai Anandhan, Aikseng Ooi, Joe G.N. Garcia, Max Costa, Eli Chapman, Donna D. Zhang
Publikováno v:
Redox Biology, Vol 65, Iss , Pp 102839- (2023)
p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we demonstrated that p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3
Externí odkaz:
https://doaj.org/article/867adb2a581b43de91087339be330784
Autor:
Pengfei Liu, Annadurai Anandhan, Jinjing Chen, Aryatara Shakya, Matthew Dodson, Aikseng Ooi, Eli Chapman, Eileen White, Joe GN. Garcia, Donna D. Zhang
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102570- (2023)
Background and aims: Caloric excess and sedentary lifestyles have led to an epidemic of obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of this study was to investigate the mechanisms underlying high fat diet
Externí odkaz:
https://doaj.org/article/a325bd8ab2114b2493bc1dc0404d0d03
Autor:
Aryatara Shakya, Matthew Dodson, Janick F. Artiola, Monica Ramirez-Andreotta, Robert A. Root, Xinxin Ding, Jon Chorover, Raina M. Maier
Publikováno v:
Water, Vol 15, Iss 9, p 1751 (2023)
Arsenic is ubiquitous in soil and water environments and is consistently at the top of the Agency for Toxic Substances Disease Registry (ATSDR) substance priority list. It has been shown to induce toxicity even at low levels of exposure. One of the m
Externí odkaz:
https://doaj.org/article/5059a29eab1c4b68b7b1887e617b4588
Autor:
Pengfei Liu, Matthew Dodson, Hui Li, Cody J. Schmidlin, Aryatara Shakya, Yongyi Wei, Joe G.N. Garcia, Eli Chapman, Pawel R. Kiela, Qing-Yu Zhang, Eileen White, Xinxin Ding, Aikseng Ooi, Donna D. Zhang
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101243- (2021)
Objective: NRF2, a transcription factor that regulates cellular redox and metabolic homeostasis, plays a dual role in human disease. While it is well known that canonical intermittent NRF2 activation protects against diabetes-induced tissue damage, l
Externí odkaz:
https://doaj.org/article/9b6867c4cff24e0b97a6adf722e6305c
Autor:
Nadeem Wajih, Swati Basu, Kamil B. Ucer, Fernando Rigal, Aryatara Shakya, Elaheh Rahbar, Vidula Vachharajani, Martin Guthold, Mark T. Gladwin, Lane M. Smith, Daniel B. Kim-Shapiro
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 442-450 (2019)
Background: Nitrite is reduced by heme-proteins and molybdenum-containing enzymes to form the important signaling molecule nitric oxide (NO), mediating NO signaling. Substantial evidence suggests that deoxygenated hemoglobin within red blood cells (R
Externí odkaz:
https://doaj.org/article/72b40045b28e4e4988bf3051e3111c48
Publikováno v:
Molecules and Cells. 46:165-175
Autor:
Matthew Dodson, Aryatara Shakya, Annadurai Anandhan, Jinjing Chen, Joe G.N. Garcia, Donna D. Zhang
Publikováno v:
Diabetes. 71:2463-2476
Despite decades of scientific effort, diabetes continues to represent an incredibly complex and difficult disease to treat. This is due in large part to the multifactorial nature of disease onset and progression and the multiple organ systems affecte
Autor:
Annadurai Anandhan, Matthew Dodson, Aryatara Shakya, Jinjing Chen, Pengfei Liu, Yongyi Wei, Hui Tan, Qian Wang, Ziyan Jiang, Kevin Yang, Joe GN Garcia, Setsuko K. Chambers, Eli Chapman, Aikseng Ooi, Yang Yang-Hartwich, Brent R. Stockwell, Donna D. Zhang
Publikováno v:
Science Advances. 9
Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron homeostasis by controlling HERC2 (E3 ubiquitin ligase for NCOA4 and
Publikováno v:
Advances in Pharmacology ISBN: 9780323997751
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9b8d9039f2846b676609e002fa592dc
https://doi.org/10.1016/bs.apha.2022.08.002
https://doi.org/10.1016/bs.apha.2022.08.002
Autor:
Pengfei Liu, Annadurai Anandhan, Jinjing Chen, Aryatara Shakya, Matthew Dodson, Aikseng Ooi, Eli Chapman, Eileen White, Joe GN. Garcia, Donna D. Zhang
Publikováno v:
Redox biology. 59
Caloric excess and sedentary lifestyles have led to an epidemic of obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of this study was to investigate the mechanisms underlying high fat diet (HFD)-induced NAFLD,