Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Arwyn T Jones"'
Autor:
Ditlev Birch, Edward J. Sayers, Malene V. Christensen, Arwyn T. Jones, Henrik Franzyk, Hanne M. Nielsen
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1672 (2023)
Cell-penetrating peptides (CPPs), such as penetratin, are often investigated as drug delivery vectors and incorporating d-amino acids, rather than the natural l-forms, to enhance proteolytic stability could improve their delivery efficiency. The pres
Externí odkaz:
https://doaj.org/article/90091dd6d59b4abf9ae6e06a1a31b1dd
Autor:
Raffaella Daniele, Chiara Brazzale, Busra Arpac, Francesco Tognetti, Cristiano Pesce, Alessio Malfanti, Edward Sayers, Francesca Mastrotto, Arwyn T. Jones, Stefano Salmaso, Paolo Caliceti
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 864 (2023)
The cell interaction, mechanism of cell entry and intracellular fate of surface decorated nanoparticles are known to be affected by the surface density of targeting agents. However, the correlation between nanoparticles multivalency and kinetics of t
Externí odkaz:
https://doaj.org/article/52a863d25508459980559096e756d81c
Autor:
Rania Hamdy, Arwyn T. Jones, Mohamed El-Sadek, Alshaimaa M. Hamoda, Sarra B. Shakartalla, Zainab M. AL Shareef, Sameh S. M. Soliman, Andrew D. Westwell
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12272 (2021)
A series of 3-(6-substituted phenyl-[1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazol-3-yl)-1H-indoles (5a–l) were designed, synthesized and evaluated for anti-apoptotic Bcl-2-inhibitory activity. Synthesis of the target compounds was readily accomplished
Externí odkaz:
https://doaj.org/article/af2a65ec3d3641878ea076cea3f09a8a
Autor:
Nielsen, Ditlev Birch, Edward J. Sayers, Malene V. Christensen, Arwyn T. Jones, Henrik Franzyk, Hanne M.
Publikováno v:
Pharmaceutics; Volume 15; Issue 6; Pages: 1672
Cell-penetrating peptides (CPPs), such as penetratin, are often investigated as drug delivery vectors and incorporating d-amino acids, rather than the natural l-forms, to enhance proteolytic stability could improve their delivery efficiency. The pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::add732c306a150608fe5d038e75c7931
Autor:
Leo R. I. Gurney, Julie Taggart, Wing-Chiu Tong, Arwyn T. Jones, Stephen C. Robson, Michael J. Taggart
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Complications arising from Preterm Birth are the leading causes of neonatal death globally. Current therapeutic strategies to prevent Preterm Birth are yet to demonstrate success in terms of reducing this neonatal disease burden. Upregulation of intr
Externí odkaz:
https://doaj.org/article/eec7800989544a0b98d76eeaf3b834db
Autor:
Olivia A Lambourne, Shane Bell, Lea P Wilhelm, Erika B Yarbrough, Gabriel G Holly, Oliver M Russell, Arwa Alghamdi, Azeza M Fdel, Carmine Varricchio, Emma L Lane, Ian G Ganley, Arwyn T Jones, Matthew S Goldberg, Youcef Mehellou
The phosphorylation of ubiquitin by the mitochondrial protein kinase PINK1, upon mitochondrial depolarization, is an important step in the repair and recycling of the mitochondria via mitophagy. As mutations in PINK1 can cause early-onset Parkinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78095e08f1981ed3d6849627cca3ac5e
https://doi.org/10.26434/chemrxiv-2022-vcp3x
https://doi.org/10.26434/chemrxiv-2022-vcp3x
Autor:
Rania Hamdy, Samia A. Elseginy, Noha I. Ziedan, Mohamed El-Sadek, Elsaid Lashin, Arwyn T. Jones, Andrew D. Westwell
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 8980 (2020)
A series of 2-(1H-indol-3-yl)-5-substituted-1,3,4-oxadiazoles, 4a–m, were designed, synthesized and tested in vitro as potential pro-apoptotic Bcl-2 inhibitory anticancer agents based on our previously reported hit compounds. Synthesis of the targe
Externí odkaz:
https://doaj.org/article/44829c0c0c0b4856acfe0d26be4756ad
Autor:
Gareth Griffiths, Jean Gruenberg, Mark Marsh, Jens Wohlmann, Arwyn T. Jones, Robert G. Parton
Nanoparticles (NP) are attractive options for the therapeutic delivery of active pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research into the development and application of NP most often starts with a diverse gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75387e1b1a6ff87865ca8f50a5ccf934
Autor:
John Wahlich, Arpan Desai, Francesca Greco, Kathryn Hill, Arwyn T. Jones, Randall J. Mrsny, Gianfranco Pasut, Yvonne Perrie, F. Philipp Seib, Leonard W. Seymour, Ijeoma F. Uchegbu
Publikováno v:
Pharmaceutics, Vol 11, Iss 5, p 210 (2019)
A special symposium of the Academy of Pharmaceutical Sciences Nanomedicines Focus Group reviewed the current status of the use of nanomedicines for the delivery of biologics drugs. This meeting was particularly timely with the recent approval of the
Externí odkaz:
https://doaj.org/article/7b044c8be3c845ceb5e4172cb9de0e79
Publikováno v:
Molecules, Vol 24, Iss 7, p 1274 (2019)
The Bcl-2 protein has been studied as an anticancer drug target in recent years, due to its gatekeeper role in resisting programmed cancer cell death (apoptosis), and the design of BH3 domain mimetics has led to the clinical approval of Venetoclax (A
Externí odkaz:
https://doaj.org/article/5b45fe5be63546acaf769bcb3d868c40