Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Arwin Aban"'
Autor:
Eric S Okerberg, Anna Hainley, Heidi Brown, Arwin Aban, Senait Alemayehu, Ann Shih, Jane Wu, Matthew P Patricelli, John W Kozarich, Tyzoon Nomanbhoy, Jonathan S Rosenblum
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172649 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0152934.].
Externí odkaz:
https://doaj.org/article/a8fee0abbac8433b9e3e6fd4953734b3
Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics.
Autor:
Eric S Okerberg, Anna Hainley, Heidi Brown, Arwin Aban, Senait Alemayehu, Ann Shih, Jane Wu, Matthew P Patricelli, John W Kozarich, Tyzoon Nomanbhoy, Jonathan S Rosenblum
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152934 (2016)
We describe the identification of a novel, tumor-specific missense mutation in the active site of casein kinase 1α (CSNK1A1) using activity-based proteomics. Matched normal and tumor colon samples were analyzed using an ATP acyl phosphate probe in a
Externí odkaz:
https://doaj.org/article/ffc6200c89354154984d306f8d950e36
Autor:
Kevin B. Dagbay, Tyzoon K. Nomanbhoy, John W. Kozarich, Jennifer L. Green, Eric Okerberg, Sergey N. Savinov, Ishankumar V Soni, Arwin Aban, Jeanne A. Hardy
Publikováno v:
Biochemistry. 58(52)
Acyl phosphates of ATP (ATPAc) and related nucleotides have proven to be useful for the interrogation of known nucleotide binding sites via specific acylation of conserved lysines (K). In addition, occasional K acylations are identified in proteins w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9951abe25ba37f1bc861f527af08a296
https://pubmed.ncbi.nlm.nih.gov/31095371
https://pubmed.ncbi.nlm.nih.gov/31095371
Autor:
Senait Alemayehu, Jonathan S. Rosenblum, Geeta Sharma, Tyzoon K. Nomanbhoy, Arwin Aban, Maria Sykes, John W. Kozarich, Subha Vogeti, Jiangyue Wu, Heidi E. Brown
Publikováno v:
Biochemistry. 55:5434-5441
Palbociclib is a cyclin-dependent kinase (CDK) 4/CDK6 inhibitor approved for breast cancer that is estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative. We profiled palbociclib in cells either sensitive or resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0fa0d0cdcae66e49708ed45db5efd4
https://doi.org/10.1021/acs.biochem.6b00629
https://doi.org/10.1021/acs.biochem.6b00629
Autor:
Jiangyue Wu, Laia Monserrat, Violeta Serra, Josilyn Sejd, Marta Palafox, Senait Alemayehu, Jennifer L. Green, Eric Okerberg, Arwin Aban, Tyzoon K. Nomanbhoy, Maria Sykes
Publikováno v:
Molecular cancer therapeutics. 18(4)
The interaction of a drug with its target is critical to achieve drug efficacy. In cases where cellular environment influences target engagement, differences between individuals and cell types present a challenge for a priori prediction of drug effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf0ed8e091e0546b183371c7bfcb181
https://pubmed.ncbi.nlm.nih.gov/30837298
https://pubmed.ncbi.nlm.nih.gov/30837298
Autor:
Kevin R. Shreder, Tyzoon K. Nomanbhoy, Ayako Nakamura, Anna Katrin Szardenings, Shigeki Seto, Jonathan S. Rosenblum, Brandon Leen, Oana Cociorva, Kai Nakamura, Bei Li, Marek Liyanage, John W. Kozarich, Qiang Li, Yasushi Kohno, Kazuhiro Yumoto, Kyoko Okada, Masahiro Nomura, Melissa C. Zhang, Arwin Aban
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5948-5951
The synthesis, GSK-3β inhibitory activity, and anti-microbial activity of bicyclic and tricyclic derivatives of the 5,7-diamino-6-fluoro-4-quinolone-3-carboxylic acid scaffold were studied. Kinase selectivity profiling indicated that members of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d9755d781aad544131d0a6c744f45f
https://doi.org/10.1016/j.bmcl.2011.07.073
https://doi.org/10.1016/j.bmcl.2011.07.073
Autor:
Helge Weissig, Nathanael S. Gray, Chris Herring, Arwin Aban, David Zhou, Heidi E. Brown, Eric Okerberg, Subadhra Jagannathan, John W. Kozarich, Qingkai Yang, Jianming Zhang, Jiing Dwan Lee, Tyzoon K. Nomanbhoy, Jiangyue Wu, Brian E. Nordin, Matthew P. Patricelli
Publikováno v:
Chemistry & Biology. 18:699-710
Protein kinases are intensely studied mediators of cellular signaling, yet important questions remain regarding their regulation and in vivo properties. Here we use a probe-based chemoprotemics platform to profile several well studied kinase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf88204473b0d9c9c120755dfc9e3bd
https://doi.org/10.1016/j.chembiol.2011.04.011
https://doi.org/10.1016/j.chembiol.2011.04.011
Autor:
Anna Hainley, Jiangyue Wu, Brian E. Nordin, Tyzoon K. Nomanbhoy, Yongsheng Liu, Jonathan S. Rosenblum, Heidi E. Brown, Arwin Aban, John W. Kozarich
Publikováno v:
Biochemistry. 54(19)
Hsp90 is an ATP-dependent chaperone of widespread interest as a drug target. Here, using an LC-MS/MS chemoproteomics platform based on a lysine-reactive ATP acyl phosphate probe, several Hsp90 inhibitors were profiled in native cell lysates. Inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc3e6114285cf11b7c39bf07a902aa8
https://pubmed.ncbi.nlm.nih.gov/25905789
https://pubmed.ncbi.nlm.nih.gov/25905789
Autor:
Helge Weissig, Doris Pik-Yiu Chun, Tyzoon K. Nomanbhoy, Min Wu, Marek Liyanage, A. Katrin Szardenings, Stephen Tanner, Arwin Aban, Matthew P. Patricelli, John W. Kozarich
Publikováno v:
Biochemistry. 46:350-358
The central role of protein kinases in signal transduction pathways has generated intense interest in targeting these enzymes for a wide range of therapeutic indications. Here we report a method for identifying and quantifying protein kinases in any
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df3081eb65efb58beca62bf0496b745
https://doi.org/10.1021/bi062142x
https://doi.org/10.1021/bi062142x
Autor:
Geeta G. Sharma, Subha Vogeti, Christa Dias, Arwin Aban, Wendy Grant, Shuzhen Wu, Tyzoon K. Nomanbhoy, Jiangyue Wu, Alemayehu Senait, Heidi E. Brown
Publikováno v:
Cancer Research. 76:B23-B23
Kinases are an important class of targets for a number of therapeutic indications, and currently, kinase inhibitors constitute a significant fraction of recently approved drugs, particularly for cancer. Using a probe-based chemoproteomics platform, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d68a3e7cc89a3c5cd1a41cf342d63196
https://doi.org/10.1158/1538-7445.fbcr15-b23
https://doi.org/10.1158/1538-7445.fbcr15-b23