Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Arwa Abu Khweek"'
Autor:
Shady Estfanous, Kathrin Krause, Midhun N. K. Anne, Mostafa Eltobgy, Kyle Caution, Arwa Abu Khweek, Kaitlin Hamilton, Asmaa Badr, Kylene Daily, Cierra Carafice, Daniel Baetzhold, Xiaoli Zhang, Tianliang Li, Haitao Wen, Mikhail A. Gavrilin, Hesham Haffez, Sameh Soror, Amal O. Amer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Burkholderia cenocepacia (B. cenocepacia) is an opportunistic bacterium; causing severe life threatening systemic infections in immunocompromised individuals including cystic fibrosis patients. The lack of gasdermin D (GSDMD) protects mice a
Externí odkaz:
https://doaj.org/article/dfc42d70a6394957ad2316ed4514e290
Autor:
Shady Estfanous, Kathrin Krause, Midhun N. K. Anne, Mostafa Eltobgy, Kyle Caution, Arwa Abu Khweek, Kaitlin Hamilton, Asmaa Badr, Kylene Daily, Cierra Carafice, Daniel Baetzhold, Xiaoli Zhang, Tianliang Li, Haitao Wen, Mikhail A. Gavrilin, Hesham Haffez, Sameh Soror, Amal O. Amer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/cfdde74256e840cda4a31d10563b25fc
Autor:
Asmaa Badr, Mostafa Eltobgy, Kathrin Krause, Kaitlin Hamilton, Shady Estfanous, Kylene P. Daily, Arwa Abu Khweek, Ahmad Hegazi, Midhun N. K. Anne, Cierra Carafice, Frank Robledo-Avila, Youssra Saqr, Xiaoli Zhang, Tracey L. Bonfield, Mikhail A. Gavrilin, Santiago Partida-Sanchez, Stephanie Seveau, Estelle Cormet-Boyaka, Amal O. Amer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) macrophages is halted, and the underlying mechanism remains unclear. Furthermore
Externí odkaz:
https://doaj.org/article/db95827f79284dbaa804f925acce7f81
Autor:
Shady Estfanous, Kylene P. Daily, Mostafa Eltobgy, Nicholas P. Deems, Midhun N. K. Anne, Kathrin Krause, Asmaa Badr, Kaitlin Hamilton, Cierra Carafice, Ahmad Hegazi, Arwa Abu Khweek, Hesham Kelani, Shahid Nimjee, Hamdy Awad, Xiaoli Zhang, Estelle Cormet-Boyaka, Hesham Haffez, Sameh Soror, Adel Mikhail, Gerard Nuovo, Ruth M. Barrientos, Mikhail A. Gavrilin, Amal O. Amer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer’s Disease (AD), though mechanisms underlying this dysfunction remain elusive. Here, primary microglia from adult AD (5xFAD) mice were utilized to d
Externí odkaz:
https://doaj.org/article/a9bb136f3f4c4634b5d53a535a5644ae
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The prevalence of asthma has been rising steadily for several decades, and continues to be a major public health and global economic burden due to both direct and indirect costs. Asthma is defined as chronic heterogeneous inflammatory diseases charac
Externí odkaz:
https://doaj.org/article/96a2fe305e4740fbb3712aee0edfccd2
Autor:
Kyle Caution, Nicholas Young, Frank Robledo-Avila, Kathrin Krause, Arwa Abu Khweek, Kaitlin Hamilton, Asmaa Badr, Anup Vaidya, Kylene Daily, Hawin Gosu, Midhun N. K. Anne, Mostafa Eltobgy, Duaa Dakhlallah, Sudha Argwal, Shady Estfanous, Xiaoli Zhang, Santiago Partida-Sanchez, Mikhail A. Gavrilin, Wael N. Jarjour, Amal O. Amer
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Gout is characterized by attacks of arthritis with hyperuricemia and monosodium urate (MSU) crystal-induced inflammation within joints. Innate immune responses are the primary drivers for tissue destruction and inflammation in gout. MSU crystals enga
Externí odkaz:
https://doaj.org/article/5f9399b8f88346d990ae67891307c8ef
Autor:
Arwa Abu Khweek, Amal O. Amer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Legionella pneumophila (L. pneumophila) is an opportunistic waterborne pathogen and the causative agent for Legionnaires' disease, which is transmitted to humans via inhalation of contaminated water droplets. The bacterium is able to colonize a varie
Externí odkaz:
https://doaj.org/article/c079ad6129ec4c07af9dfe85a916d105
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146410 (2016)
L. pneumophila is the causative agent of Legionnaires' disease, a human illness characterized by severe pneumonia. In contrast to those derived from humans, macrophages derived from most mouse strains restrict L. pneumophila replication. The restrict
Externí odkaz:
https://doaj.org/article/fac2c9e81834499082e9c5e806d602d1
Autor:
Cierra Carafice, Midhun N. K. Anne, Amal O. Amer, Xiaoli Zhang, Mostafa Eltobgy, Arwa Abu Khweek, Kathrin Krause, Mikhail A. Gavrilin, Shady Estfanous, Kylene Daily, Jeffrey R. Tonniges, Kaitlin Hamilton, Narasimham L. Parinandi, Asmaa Badr, Daniel Baetzhold
Publikováno v:
J Cyst Fibros
Background Mitochondria play a key role in immune defense pathways, particularly for macrophages. We and others have previously demonstrated that cystic fibrosis (CF) macrophages exhibit weak autophagy activity and exacerbated inflammatory responses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb81922e6e56f4fd9397be406f5df681
https://doi.org/10.1016/j.jcf.2020.10.006
https://doi.org/10.1016/j.jcf.2020.10.006
Autor:
Shady Estfanous, Midhun N. K. Anne, Kara N. Corps, Kathrin Krause, Mostafa Eltobgy, Cierra Carafice, Zayed Attia, Kylene Daily, Eunsoo Kim, Prosper N. Boyaka, Kaitlin Hamilton, Mikhail A. Gavrilin, Asmaa Badr, Arwa Abu Khweek, Marisa R. Joldrichsen, Xiaoli Zhang, Amal O. Amer
Publikováno v:
Cell Immunol
Asthma is an inflammatory lung disorder characterized by mucus hypersecretion, cellular infiltration, and bronchial hyper-responsiveness. House dust mites (HDM) are the most prevalent cause of allergic sensitization. Canonical and noncanonical inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea6266f03546a5d0d5a001ce3cc1876
https://pubmed.ncbi.nlm.nih.gov/34800762
https://pubmed.ncbi.nlm.nih.gov/34800762