Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Arwa A. Abugable"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
DNA:RNA hybrids (R-loops) are products of transcription that impact genome integrity and gene expression. Here the authors reveal a mechanism for regulating R-loops in a ubiquitination-dependent manner controlled by the activities of USP11 and KEAP1
Externí odkaz:
https://doaj.org/article/eb0bfd4248dd4385a038034986f146a7
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
R-loops are by-products of transcription that must be tightly regulated to maintain genomic stability and gene expression. Here, we describe a mechanism for the regulation of the R-loop-specific helicase, senataxin (SETX), and identify the ubiquitin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1db6d97a3cecb1e0fd104ccfcadc2e4
https://doi.org/10.1038/s41467-021-25459-w
https://doi.org/10.1038/s41467-021-25459-w
Autor:
Swagat, Ray, Arwa A, Abugable, Jacob, Parker, Kirsty, Liversidge, Nelma M, Palminha, Chunyan, Liao, Adelina E, Acosta-Martin, Cleide D S, Souza, Mateusz, Jurga, Ian, Sudbery, Sherif F, El-Khamisy
Publikováno v:
Nature. 609(7929)
Oxidative genome damage is an unavoidable consequence of cellular metabolism. It arises at gene regulatory elements by epigenetic demethylation during transcriptional activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::253a0f1af9ec07479f091b8573150f73
https://pubmed.ncbi.nlm.nih.gov/36171374
https://pubmed.ncbi.nlm.nih.gov/36171374
Autor:
Corey E. Hayford, Keisha N. Hardeman, B. Bishal Paudel, Leonard A. Harris, Vito Quaranta, Arwa A. Abugable, Darren R. Tyson
Publikováno v:
Biophysical Journal. 114:1499-1511
Targeted therapy is an effective standard of care in BRAF-mutated malignant melanoma. However, the duration of tumor remission varies unpredictably among patients, and relapse is almost inevitable. Here, we examine the responses of several BRAF-mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623ec06a852959f048c2cf05d00dd44b
https://doi.org/10.1016/j.bpj.2018.01.016
https://doi.org/10.1016/j.bpj.2018.01.016
Autor:
Mohamed H. Alkordi, Rana R. Haikal, Arwa A. Abugable, Stavros Karakalos, Mohamed H. Hassan, Ahmed H. Ibrahim, Worood A. El-Mehalmey, Omar Zaki
Publikováno v:
Journal of Materials Chemistry A. 6:2742-2751
A one-pot synthesis in quantitative yield is described to construct a composite of the amino-derivative Zr carboxylate metal–organic framework (MOF) and silica gel (UiO-66-NH2@silica). The silica gel was utilized as a porous solid support to enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bad60d143604446be35706933288cc4a
https://doi.org/10.1039/c7ta08281a
https://doi.org/10.1039/c7ta08281a
Autor:
Rana R. Haikal, Mohamed H. Hassan, Mohamed H. Alkordi, Hamdy H. Hassan, Magdi H. Yacoub, Perry J. Pellechia, Stavros Karakalos, Ahmed B. Soliman, Arwa A. Abugable
Publikováno v:
ACS Applied Materials & Interfaces. 9:27918-27926
A facile one-pot, bottom-up approach to construct composite materials of graphene and a pyrimidine-based porous-organic polymer (PyPOP), as host for immobilizing human hemoglobin (Hb) biofunctional molecules, is reported. The graphene was selected be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f87fe27bbfc92bd90d147af206d952d
https://doi.org/10.1021/acsami.7b06146
https://doi.org/10.1021/acsami.7b06146
Autor:
Mady Elbahri, Mohamed H. Alkordi, Ahmed B. Soliman, Worood A. El-Mehalmey, Stavros Karakalos, Manuel Tsotsalas, Tran Ngoc Huan, Marita Heinle, Marc Fontecave, Mohamed H. Hassan, Arwa A. Abugable
Publikováno v:
ACS Catalysis. 7(11):7847-7854
A facile, postsynthetic treatment of a designed composite of pyrimidine-based porous-organic polymer and graphene (PyPOP@G) with ionic Pt, and the subsequent uniform electrodeposition of Pt metallic within the pores, led to the formation of a composi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75b011ee026733dbd25ebae73af2b7b
http://juuli.fi/Record/0283675217
http://juuli.fi/Record/0283675217
Publikováno v:
International Journal of Nanomedicine
Purpose The objective of this study is to develop a facile tool for the absolute detection and quantification of nucleic acid transcripts, using a gold nanoparticle-based optical biosensor. Topoisomerase 1 (TOP1) and tyrosyl DNA phosphodiesterase 2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34dd3795f8e56ea76f75f810398634f2
https://pubmed.ncbi.nlm.nih.gov/30555231
https://pubmed.ncbi.nlm.nih.gov/30555231
Autor:
Mohamed H. Hassan, Mohamed H. Alkordi, Worood A. Elmehelmey, Abdou Hassanien, Ahmed B. Soliman, Stavros Karakalos, Arwa A. Abugable, Mady Elbahri
Publikováno v:
Chemical communications (Cambridge, England). 55(1)
A novel approach to construct a highly active and durable Ni(OH)2 nanoparticle/graphene hybrid electrocatalyst for the oxygen-evolution reaction (OER) is reported. This approach utilized the Ni-loaded, graphene-supported, Zr–carboxylate metal–org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df27bb9ece3f5f3bcc2d48ac2f3b9b1
https://pubmed.ncbi.nlm.nih.gov/30378599
https://pubmed.ncbi.nlm.nih.gov/30378599
Publikováno v:
Trends in Genetics
Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4035420eb3e0bdb58d35951128949a9c
https://pubmed.ncbi.nlm.nih.gov/29807746
https://pubmed.ncbi.nlm.nih.gov/29807746