Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Arvydas Maminishkis"'
Autor:
Belinda J. Hernandez, Nikolai P. Skiba, Karolina Plössl, Madison Strain, Yutao Liu, Daniel Grigsby, Una Kelly, Martha A. Cady, Vikram Manocha, Arvydas Maminishkis, TeddiJo Watkins, Sheldon S. Miller, Allison Ashley‐Koch, W. Daniel Stamer, Bernhard H. F. Weber, Catherine Bowes Rickman, Mikael Klingeborn
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 10, Pp n/a-n/a (2023)
Abstract The retinal pigmented epithelium (RPE) constitutes the outer blood‐retinal barrier, enables photoreceptor function of the eye, and is constantly exposed to oxidative stress. As such, dysfunction of the RPE underlies pathology leading to de
Externí odkaz:
https://doaj.org/article/d61d8d2d0c8f4f56a964ddb524e39f94
Autor:
Francesca Barone, Juan Amaral, Irina Bunea, Mitra Farnoodian, Rohan Gupta, Rishabh Gupta, Dara Baker, M. Joseph Phillips, Richard J. Blanch, Arvydas Maminishkis, David M. Gamm, Kapil Bharti
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Over 30 million people worldwide suffer from untreatable vision loss and blindness associated with childhood-onset and age-related eye diseases caused by photoreceptor (PR), retinal pigment epithelium (RPE), and choriocapillaris (CC) degeneration. Re
Externí odkaz:
https://doaj.org/article/31aba2db034c4e20911854cd3b29f75e
Autor:
Ameera Mungale, David M. McGaughey, Congxiao Zhang, Sairah Yousaf, James Liu, Brian P. Brooks, Arvydas Maminishkis, Temesgen D. Fufa, Robert B. Hufnagel
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The macula and fovea comprise a highly sensitive visual detection tissue that is susceptible to common disease processes like age-related macular degeneration (AMD). Our understanding of the molecular determinants of high acuity vision remains unclea
Externí odkaz:
https://doaj.org/article/dacfca79c6464c269d748823569aaea9
Autor:
Sanghamitra Bhattacharyya, Johnathon Sturgis, Arvydas Maminishkis, Sheldon S. Miller, Vera L. Bonilha
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9938 (2022)
The retina and RPE cells are regularly exposed to chronic oxidative stress as a tissue with high metabolic demand and ROS generation. DJ-1 is a multifunctional protein in the retina and RPE that has been shown to protect cells from oxidative stress i
Externí odkaz:
https://doaj.org/article/a6993b2b99cd4e1e9de9b4e10afb8efc
Autor:
Kelly Mulfaul, Ema Ozaki, Nilisha Fernando, Kiva Brennan, Kathleen R. Chirco, Emma Connolly, Chris Greene, Arvydas Maminishkis, Robert G. Salomon, Mikhail Linetsky, Riccardo Natoli, Robert F. Mullins, Matthew Campbell, Sarah L. Doyle
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2209-2224.e5 (2020)
Summary: Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction. Here we show tha
Externí odkaz:
https://doaj.org/article/835c88f2ea654e568ca728ae96a0f4bf
Autor:
Helen Louise May-Simera, Qin Wan, Balendu Shekhar Jha, Juliet Hartford, Vladimir Khristov, Roba Dejene, Justin Chang, Sarita Patnaik, Quanlong Lu, Poulomi Banerjee, Jason Silver, Christine Insinna-Kettenhofen, Dishita Patel, Mostafa Lotfi, May Malicdan, Nathan Hotaling, Arvydas Maminishkis, Rupa Sridharan, Brian Brooks, Kiyoharu Miyagishima, Meral Gunay-Aygun, Rajarshi Pal, Christopher Westlake, Sheldon Miller, Ruchi Sharma, Kapil Bharti
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 189-205 (2018)
Summary: Primary cilia are sensory organelles that protrude from the cell membrane. Defects in the primary cilium cause ciliopathy disorders, with retinal degeneration as a prominent phenotype. Here, we demonstrate that the retinal pigment epithelium
Externí odkaz:
https://doaj.org/article/bfaae5556aaf4f70affe565c4099f9ee
Autor:
Ignacio Benedicto, Guillermo L. Lehmann, Michael Ginsberg, Daniel J. Nolan, Rohan Bareja, Olivier Elemento, Zelda Salfati, Nazia M. Alam, Glen T. Prusky, Pierre Llanos, Sina Y. Rabbany, Arvydas Maminishkis, Sheldon S. Miller, Shahin Rafii, Enrique Rodriguez-Boulan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Establishment of the outer blood-retina barrier is a hallmark of retinal development but the contribution of choroid endothelial cells (ECs) is not known. Here the authors show in the developing mouse retina that ECs remodel the basement membrane and
Externí odkaz:
https://doaj.org/article/919b83179e8542b08aff5bc2e85e591a
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23148 (2011)
Ciliary neurotrophic factor (CNTF) protects photoreceptors and regulates their phototransduction machinery, but little is known about CNTF's effects on retinal pigment epithelial (RPE) physiology. Therefore, we determined the expression and localizat
Externí odkaz:
https://doaj.org/article/bad8859b5eac4139879abf5f7752736a
Autor:
Min Jae Song, Russ Quinn, Eric Nguyen, Christopher Hampton, Ruchi Sharma, Tea Soon Park, Céline Koster, Ty Voss, Carlos Tristan, Claire Weber, Anju Singh, Roba Dejene, Devika Bose, Yu-Chi Chen, Paige Derr, Kristy Derr, Sam Michael, Francesca Barone, Guibin Chen, Manfred Boehm, Arvydas Maminishkis, Ilyas Singec, Marc Ferrer, Kapil Bharti
Publikováno v:
Nature Methods. 20:149-161
Age-related macular degeneration (AMD), a leading cause of blindness, initiates in the outer-blood-retina-barrier (oBRB) formed by the retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris. The mechanisms of AMD initiation and prog
Autor:
Mitra, Farnoodian, Devika, Bose, Vladimir, Khristov, Praveen Joseph, Susaimanickam, Savitri, Maddileti, Indumathi, Mariappan, Mones, Abu-Asab, Maria, Campos, Rafael, Villasmil, Qin, Wan, Arvydas, Maminishkis, David, McGaughey, Francesca, Barone, Rebekah L, Gundry, Daniel R, Riordon, Kenneth R, Boheler, Ruchi, Sharma, Kapil, Bharti
Publikováno v:
Stem Cell Reports. 17:2438-2450
Stargardt retinopathy is an inherited form of macular degeneration caused by mutations in gene ABCA4 and characterized by the accumulation of lipid-rich deposits in the retinal pigment epithelium (RPE), RPE atrophy, and photoreceptor cell death. Inad