Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Arvinder Sran"'
Autor:
David C. Carroll, Xiulan Zhou, John McLaughlin, Julie Sheung, Rajinder Singh, Sarkiz D. Issakani, Simon J. Shaw, Lyuben Tsvetkov, Arvinder Sran, Donald G. Payan, Jianing Huang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5199-5202
Structure-activity relationships have been developed around 5-bromo-8-toluylsulfonamidoquinoline 1 a hit compound in an assay for the interaction of the E3 ligase Skp2 with Cks1, part of the SCF ligase complex. Disruption of this protein-protein inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703078fae8dbfeacac872aa292ac27b2
https://doi.org/10.1016/j.bmcl.2015.09.067
https://doi.org/10.1016/j.bmcl.2015.09.067
Autor:
Arvinder Sran, Raja Kawas, Sadie R Bartholomew Ingle, Hector Rodriguez, Yonghong Song, Robert L. Anderson
Mavacamten, formerly known as MYK-461 is a recently discovered novel small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy, one of the most prevalent heritable cardiovascula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4865775089766fac86f5aa1d1e04dddf
https://europepmc.org/articles/PMC5633120/
https://europepmc.org/articles/PMC5633120/
Cardiac Selective Modulator of Human Myosin for the Treatment of Genetic Hypertrophic Cardiomyopathy
Autor:
Christopher P. Willits, Hector Rodriguez, Arvinder Sran, Robert L. Anderson, Yonghong Song, Johan D. Oslob, Haben Ghermazien
Publikováno v:
Biophysical Journal. 106(2):729a-730a
Genetic hypertrophic cardiomyopathy (HCM) results from mutations in the cardiac sarcomere, including β-cardiac myosin, with HCM afflicting about 1 out of every 500 people in the United States. HCM is characterized by hyper-contractility and myocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7c1f2228b7f0e9abab12c718f9a4a6
Autor:
Arvinder Sran, Hector M. Rodriguez, Yonghong Song, Johan D. Oslob, Raja Kawas, Stephanie Whitman-Cox
Publikováno v:
Biophysical Journal. 106:562a
We have identified a small molecule inhibitor, MYK0000461, of the cardiac myosin ATPase. This agent was characterized in steady state and transient kinetic assays to understand its mechanism of action. MYK0000461 decreases the steady-state rate of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7477b3363bda83a437cd871b0895cfd
https://doi.org/10.1016/j.bpj.2013.11.3123
https://doi.org/10.1016/j.bpj.2013.11.3123