Sodium transport is modulated by p38 kinase-dependent cross-talk between ENaC and Na,K-ATPase in collecting duct principal cells

Autor: Udo Hasler, Eric Féraille, Yubao Wang, Thomas Ernandez, Valérie Leroy, Eva Dizin, Alain Doucet, Arvid B. Maunsbach, Sophie de Seigneux, Pierre-Yves Martin

Publikováno v: Journal of the American Society of Nephrology : JASN
Journal of the American Society of Nephrology, Vol. 25, No 2 (2014) pp. 250-259
Wang, Y-B, Leroy, V, Maunsbach, A B, Doucet, A, Hasler, U, Dizin, E, Ernandez, T, de Seigneux, S, Martin, P-Y & Féraille, E 2014, ' Sodium transport is modulated by p38 kinase-dependent cross-talk between ENaC and Na,K-ATPase in collecting duct principal cells ', Journal of the American Society of Nephrology, vol. 25, no. 2, pp. 250-9 . https://doi.org/10.1681/ASN.2013040429

In relation to dietary Na(+) intake and aldosterone levels, collecting duct principal cells are exposed to large variations in Na(+) transport. In these cells, Na(+) crosses the apical membrane via epithelial Na(+) channels (ENaC) and is extruded int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68e778b5a3dc3e86fd4ec723911268a

A Metabonomic and Proteomic Analysis of Changes in IMCD3 Cells Chronically Adapted to Hypertonicity

Autor: Juan M. Capasso, Uwe Christians, Jost Klawitter, Lewis M. Brown, Kaarina Pihakaski-Maunsbach, Dieter Leibfritz, Laurence Chan, Nestor E. Almeida, Arvid B. Maunsbach, Christopher J. Rivard, Tomas Berl

Publikováno v: Klawitter, J, Rivard, C J, Brown, L M, Capasso, J M, Almeida, N E, Maunsbach, A B, Pihakaski-Maunsbach, K, Berl, T, Leibfritz, D, Christians, U & Chan, L 2008, ' A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicity ', Nephron Journals, vol. 109, no. 1, pp. p1-10 . https://doi.org/10.1159/000129074

Background: The genomic response to adaptation of IMCD3 cells to hypertonicity results in both upregulation and downregulation of a variety of genes. Method: The present study was undertaken to assess the metabonomic and proteomic response of IMCD3 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e9219d7f61de840f7a2a06d7935098
https://doi.org/10.1159/000129074

Redistribution of Myosin VI from Top to Base of Proximal Tubule Microvilli during Acute Hypertension

Autor: Patrick K. K. Leong, Alicia A. McDonough, Arvid B. Maunsbach, Li E. Yang

Publikováno v: Journal of the American Society of Nephrology. 16:2890-2896

During acute hypertension, Na(+)/H(+) exchangers (NHE3) retract from top to base of proximal tubule microvilli (MV) and Na(+) reabsorption decreases in proximal tubule. This study aimed to determine whether the actin-based motor myosin VI coordinatel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f258f3badfaf96a143538b2158da71b0
https://doi.org/10.1681/asn.2005040366

Changes of Rat Kidney AQP2 and Na,K-ATPase mRNA Expression in Lithium-Induced Nephrogenic Diabetes insipidus

Autor: Erik Østergaard Jensen, Søren Nielsen, Kaarina Pihakaski-Maunsbach, Arvid B. Maunsbach, Tae-Hwan Kwon, Ulla Helt Laursen

Publikováno v: Nephron Experimental Nephrology. 97:e1-e16

Background/Aim: In a rat model, lithium treatment is associated with polyuria and severe downregulation of aquaporin-2 (AQP2) protein in the inner medulla (IM) or in the whole kidney. However, it is not known (1) to what extent this downregulation oc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc549c20f866086a9645eaaf549c6a8e
https://doi.org/10.1159/000077593

Immunocytochemical Localization of Na,K-ATPase Gamma Subunit and CHIF in Inner Medulla of Rat Kidney

Autor: Henrik Vorum, Arvid B. Maunsbach, Kaarina Pihakaski-Maunsbach, Steven J.D. Karlish, Else-Merete Løcke, Haim Garty

Publikováno v: Pihakaski-Maunsbach, K, Vorum, H, Løcke, E-M, Garty, H, Karlish, S J D & Maunsbach, A B 2003, ' Immunocytochemical localization of Na,K-ATPase gamma subunit and CHIF in inner medulla of rat kidney ' Ann. N. Y. Acad. Sci., vol. 986, pp. 401-409 .

The gamma subunit of Na,K-ATPase and CHIF both belong to the FXYD single-membrane-spanning protein family and have been suggested to have regulatory functions in kidney tubules. CHIF is known to be present in the collecting duct, and gamma has been d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91dddde1f349fd22a8ee202d2b153847
https://doi.org/10.1111/j.1749-6632.2003.tb07221.x