Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging

Autor: Yunpeng Ye, Laurent Devel, Mani Salarian, Mehran M. Sadeghi, Saranya Rajendran, Arvene Golbazi, Parnaz Boodagh, Nowshin Sanzida, Kiran Babu Gona, Terence L. Wu, Jakub Toczek, Jae-Joon Jung, Gunjan Kukreja

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (23), pp.15037-15049. ⟨10.1021/acs.jmedchem.0c01514⟩
Journal of Medicinal Chemistry, 2020, 63 (23), pp.15037-15049. ⟨10.1021/acs.jmedchem.0c01514⟩
J Med Chem

International audience; Macrophage elastase [matrix metalloproteinase (MMP)-12] is the most upregulated MMP in abdominal aortic aneurysm (AAA) and, hence, MMP-12-targeted imaging may predict AAA progression and rupture risk. Here, we report the desig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64535d2ff4fda2ad2c20194515344c32
https://hal.inrae.fr/hal-03320529

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome

Autor: David P. Nusinow, Hannah Parzen, Kurt Baltier, J. Wade Harper, Arvene Golbazi, Keegan Stricker, Edward L. Huttlin, Melanie P. Gygi, Steven P. Gygi, Gabriela Zarraga, Sipei Fu, Ramin Rad, Brandon M. Gassaway, Joao A. Paulo, Joe R. Cannon, Laura Pontano Vaites, Tian Zhang, Alexandra Panov, Stanley Tam, Sanjukta Guha Thakurta, Raphael J. Bruckner, Joshua Pan, Eila Maenpaa, Fana Gebreab, Devin K. Schweppe, Alexandra Thornock, John Szpyt, José Navarrete-Perea

Publikováno v: Cell

Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction net

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf5d903a20e6f7220c1b9c5f68bfc09
https://doi.org/10.1016/j.cell.2021.04.011