Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models

Autor: Mavroeidi, Panagiota, Arvanitaki, Fedra, Vetsi, Maria, Becker, Stefan, Vlachakis, Dimitrios, Jensen, Poul Henning, Stefanis, Leonidas, Xilouri, Maria

Publikováno v: Mavroeidi, P, Arvanitaki, F, Vetsi, M, Becker, S, Vlachakis, D, Jensen, P H, Stefanis, L & Xilouri, M 2022, ' Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models ', Autophagy, vol. 18, no. 9, pp. 2104-2133 . https://doi.org/10.1080/15548627.2021.2016256
Autophagy

Accumulation of the neuronal protein SNCA/alpha-synuclein and of the oligodendroglial phosphoprotein TPPP/p25A within the glial cytoplasmic inclusions (GCIs) represents the key histophathological hallmark of multiple system atrophy (MSA). Even though

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73df00d509ef0d8891a89cfe35e4fd89

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.

Autor: Mavroeidi, Panagiota, Arvanitaki, Fedra, Karakitsou, Anastasia-Kiriaki, Vetsi, Maria, Kloukina, Ismini, Zweckstetter, Markus, Giller, Karin, Becker, Stefan, Sorrentino, Zachary A., Giasson, Benoit I., Jensen, Poul Henning, Stefanis, Leonidas, Xilouri, Maria

Publikováno v: Acta Neuropathologica; Sep2019, Vol. 138 Issue 3, p415-441, 27p

Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models.

Autor: Mavroeidi P; Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Arvanitaki F; Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Vetsi M; Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Becker S; Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany., Vlachakis D; Genetics and Computational Biology Group, Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece., Jensen PH; DANDRITE-Danish Research Institute of Translational Neuroscience & Department of Biomedicine, University of Aarhus, Aarhus, Denmark., Stefanis L; Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.; 1st Department of Neurology, Medical School, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece., Xilouri M; Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Publikováno v: Autophagy [Autophagy] 2022 Sep; Vol. 18 (9), pp. 2104-2133. Date of Electronic Publication: 2022 Jan 09.