Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation.

Autor: Chatterjee BK; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA., Alam M; Department of Internal Medicine- Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, 48109, USA., Chakravorty A; Department of Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA., Lacy SM; Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, 48109, USA., Rech J; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, MI, 48109, USA.; College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109, USA., Brooks CL 3rd; Department of Internal Medicine- Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, 48109, USA., Arvan PD; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Internal Medicine- Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, 48109, USA., Truttmann MC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.; Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 16. Date of Electronic Publication: 2024 Jul 16.