Výsledky vyhledávání - "Arushi Chauhan"

Akademický článek

Structural-Based Virtual Screening of FDA-Approved Drugs Repository for NSP16 Inhibitors, Essential for SARS-COV-2 Invasion Into Host Cells: Elucidation From MM/PBSA Calculation

Publikováno v: Bioinformatics and Biology Insights, Vol 17 (2023)

NSP16 is one of the structural proteins of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) necessary for its entrance to the host cells. It exhibits 2’O-methyl-transferase (2’O-MTase) activity of NSP16 using methyl group from S-a

Externí odkaz: https://doaj.org/article/2c0327e2c57741fabb747521630aafd2

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Structural, molecular hybridization and network based identification of miR-373-3p and miR-520e-3p as regulators of NR4A2 human gene involved in neurodegeneration

Autor: Jitender Singh, Ashvinder Raina, Namrata Sangwan, Arushi Chauhan, Pramod K Avti

Publikováno v: Nucleosides, Nucleotides & Nucleic Acids. 41:419-443

MicroRNAs (miRNAs) are short non-coding RNAs with a 22 nucleotide sequence length and docks to the 3'UTR/5'UTR of the gene to regulate their mRNA translation to play a vital role in neurodegenerative diseases. The Nuclear Receptor gene (NR4A2), a tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834e5466bd7885a18619e24ed65bdbd5
https://doi.org/10.1080/15257770.2022.2048851

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Screening and identification of phytochemical drug molecules against mutant BRCA1 receptor of breast cancer using computational approaches

Autor: Jitender Singh, Namrata Sangwan, Arushi Chauhan, Phulen Sarma, Ajay Prakash, Bikash Medhi, Pramod K. Avti

Publikováno v: Molecular and Cellular Biochemistry. 477:885-896

The American Cancer Society claims that breast cancer is the second most significant cause of cancer-related death, with over one million women diagnosed each year. Breast cancer linked to the BRCA1 gene has a significant risk of mortality and recurr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df29d160ad8048c64237bf7fd888a7d7
https://doi.org/10.1007/s11010-021-04338-4

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Allosteric modulation of conserved motifs and helices in 5HT2BR: Advances drug discovery and therapeutic approach towards drug resistant epilepsy

Autor: Arushi Chauhan, Namrata Sangwan, Jitender Singh, Ajay Prakash, Bikash Medhi, Pramod K. Avti

The 5HT2BR, class-A GPCR is a new target, and its significance for seizure reduction in Dravet syndrome is just now gaining interest, suggesting its specific role in epileptic seizure management. Homology modeling of human 5HT2BR (P41595), was perfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9b6e1fed9e53425cfc0fb9f27f4b84

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An insight into the simulation directed understanding of the mechanism in SARS CoV-2 N-CTD, dimer integrity, and RNA-binding: Identifying potential antiviral inhibitors

Autor: Anusuya Bhattacharyya, Bikash Medhi, Nishant Shekhar, Subodh Kumar, Saurabh Sharma, Hardeep Kaur, Arushi Chauhan, Pramod Avti, Jitender Singh, Ajay Prakash, Manisha Prajapat, Namrata Sangwan, Phulen Sarma

Publikováno v: Journal of Biomolecular Structure and Dynamics. 40:13912-13924

Coronavirus 2019 is a transmissible disease and has caused havoc throughout the world. The present study identifies the novel potential antiviral inhibitors against the nucleocapsid C-terminal domain that aids in RNA-binding and replication. A total

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186b9a9affdfa447e6dd2088f58d8bc4
https://doi.org/10.1080/07391102.2021.1996463

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Structure and dynamic simulation-based interactions of benzenoids, pyrroles and organooxygen compounds for effective targeting of GPX4 in ischemic stroke

Autor: Namrata Sangwan, Jitender Singh, Arushi Chauhan, Ajay Prakash, Krishan L. Khanduja, Bikash Medhi, Pramod K Avti

Publikováno v: Journal of biomolecular structuredynamics.

The discovery of a novel drug for ischemic stroke is plagued by expensive and unsuccessful outcomes. FDA-approved drugs could be a viable repurposing strategy for stroke therapy. Emerging evidence suggests the regulating role of Glutathione peroxidas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958e46c2fc95bedd24ec3b7c8ecbbf9e
https://pubmed.ncbi.nlm.nih.gov/36326469

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Computational basis of SARS-CoV 2 main protease inhibition: an insight from molecular dynamics simulation based findings

Autor: Arushi Chauhan, Manisha Prajapat, Hardeep Kaur, Bikash Medhi, Nishant Shekhar, Pramod Avti, Phulen Sarma, Anusuya Bhattacharyya, Saurabh Sharma, Ajay Prakash, Subodh Kumar

Publikováno v: Journal of Biomolecular Structure & Dynamics
article-version (VoR) Version of Record

The coronavirus disease 2019 (COVID-19) pandemic is caused by newly discovered severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). One of the striking targets amongst all the proteins in coronavirus is the main protease (Mpro), as it plays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea83b2b369cad6470a9e20939d36248
http://europepmc.org/articles/PMC8127165

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