Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Arunima Purkayastha"'
Autor:
Peter J. Mullen, Gustavo Garcia, Arunima Purkayastha, Nedas Matulionis, Ernst W. Schmid, Milica Momcilovic, Chandani Sen, Justin Langerman, Arunachalam Ramaiah, David B. Shackelford, Robert Damoiseaux, Samuel W. French, Kathrin Plath, Brigitte N. Gomperts, Vaithilingaraja Arumugaswami, Heather R. Christofk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate vira
Externí odkaz:
https://doaj.org/article/fb48f36f0ee14f8194aa51fcf0be0cc6
Autor:
Paul G. Ayoub, Arunima Purkayastha, Jason Quintos, Curtis Tam, Lindsay Lathrop, Kevin Tam, Marlene Ruiz, Roger P. Hollis, Brigitte N. Gomperts, Donald B. Kohn
Publikováno v:
Frontiers in Virology, Vol 1 (2021)
The spike (S) glycoprotein of SARS-Cov-2 facilitates viral entry into target cells via the cell surface receptor angiotensin-converting enzyme 2 (ACE2). Third generation HIV-1 lentiviral vectors can be pseudotyped to replace the native CD4 tropic env
Externí odkaz:
https://doaj.org/article/efa1938c3f3c4807a4e0cd637ebbc8fb
Autor:
Apoorva Mulay, Bindu Konda, Gustavo Garcia, Jr., Changfu Yao, Stephen Beil, Jaquelyn M. Villalba, Colin Koziol, Chandani Sen, Arunima Purkayastha, Jay. K. Kolls, Derek A. Pociask, Patrizia Pessina, Julio Sainz de Aja, Carolina Garcia-de-Alba, Carla F. Kim, Brigitte Gomperts, Vaithilingaraja Arumugaswami, Barry R. Stripp
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109055- (2021)
Summary: Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although infection initiates in the proximal airways, severe and sometimes fatal symptoms
Externí odkaz:
https://doaj.org/article/c6b335eff48e42068ebd55ba5f9b3751
Autor:
Gustavo Garcia, Jr., Arun Sharma, Arunachalam Ramaiah, Chandani Sen, Arunima Purkayastha, Donald B. Kohn, Mark S. Parcells, Sebastian Beck, Heeyoung Kim, Malina A. Bakowski, Melanie G. Kirkpatrick, Laura Riva, Karen C. Wolff, Brandon Han, Constance Yuen, David Ulmert, Prabhat K. Purbey, Phillip Scumpia, Nathan Beutler, Thomas F. Rogers, Arnab K. Chatterjee, Gülsah Gabriel, Ralf Bartenschlager, Brigitte Gomperts, Clive N. Svendsen, Ulrich A.K. Betz, Robert D. Damoiseaux, Vaithilingaraja Arumugaswami
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108940- (2021)
Summary: SARS-CoV-2 has currently precipitated the COVID-19 global health crisis. We developed a medium-throughput drug-screening system and identified a small-molecule library of 34 of 430 protein kinase inhibitors that were capable of inhibiting th
Externí odkaz:
https://doaj.org/article/0ec6b74831ff49ac9031607cb9aa9694
Publikováno v:
eLife, Vol 5 (2016)
A well-characterized metabolic landmark for aggressive cancers is the reprogramming from oxidative phosphorylation to aerobic glycolysis, referred to as the Warburg effect. Models mimicking this process are often incomplete due to genetic complexitie
Externí odkaz:
https://doaj.org/article/c31b34ec0cfb477192c939dc2fba27cd
Publikováno v:
Virology. 581:71-80
Autor:
David W. Shia, WooSuk Choi, Preethi Vijayaraj, Valarie Vuong, Jenna M. Sandlin, Michelle M. Lu, Adam Aziz, Caliope Marin, Cody J. Aros, Chandani Sen, Abdo Durra, Andrew J. Lund, Arunima Purkayastha, Tammy M. Rickabaugh, Thomas G. Graeber, Brigitte N. Gomperts
Publikováno v:
Oncogene, vol 42, iss 6
Small cell lung cancer (SCLC) remains a lethal disease with a dismal overall survival rate of 6% despite promising responses to upfront combination chemotherapy. The key drivers of such rapid mortality include early metastatic dissemination in the na
Autor:
Cody J. Aros, David W Shia, Changfu Yao, Kathrin Plath, Preethi Vijayaraj, Eszter K. Vladar, Gianni Carraro, Arunima Purkayastha, Martin Mense, Emily J. Wilson, Jason Ernst, Justin Langerman, Barry R. Stripp, Aleks Szymaniak, Guangzhu Zhang, Shan Sabri, Ben A Calvert, Tammy M. Rickabaugh, Amy L. Ryan, Brigitte N. Gomperts, Bindu Konda, Edo Israely, Andrew J. Lund, Zareeb Lorenzana, Junjie Lu, John Mahoney, Scott H. Randell, Michael Mulligan, Priyanka Bhatt
Publikováno v:
Nat Med
Nature medicine, vol 27, iss 5
Nature medicine, vol 27, iss 5
Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts more than 70,000 people. People with CF experience multi-organ dysfunction resulting from aberrant electrolyte transport across polarized epithelia due to mutations in the cy
Autor:
Anton Petcherski, Madhav Sharma, Sandro Satta, Maria Daskou, Hariclea Vasilopoulos, Cristelle Hugo, Eleni Ritou, Barbara Jane Dillon, Eileen Fung, Gustavo Garcia, Claudio Scafoglio, Arunima Purkayastha, Brigitte N Gomperts, Gregory A Fishbein, Vaithilingaraja Arumugaswami, Marc Liesa, Orian S Shirihai, Theodoros Kelesidis
Publikováno v:
bioRxiv
SummaryTo date, there is no effective oral antiviral against SARS-CoV-2 that is also anti-inflammatory. Herein, we show that the mitochondrial antioxidant mitoquinone/mitoquinol mesylate (Mito-MES), a dietary supplement, has potent antiviral activity
Autor:
David W, Shia, WooSuk, Choi, Preethi, Vijayaraj, Valarie, Vuong, Jenna M, Sandlin, Michelle M, Lu, Adam, Aziz, Caliope, Marin, Cody J, Aros, Chandani, Sen, Abdo, Durra, Andrew J, Lund, Arunima, Purkayastha, Tammy M, Rickabaugh, Thomas G, Graeber, Brigitte N, Gomperts
Publikováno v:
Oncogene.
Small cell lung cancer (SCLC) remains a lethal disease with a dismal overall survival rate of 6% despite promising responses to upfront combination chemotherapy. The key drivers of such rapid mortality include early metastatic dissemination in the na