Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Arunima Ganguli"'
Autor:
Gary Salmon, Harvey Wong, Maxine Norman, Adrian Barnard, Aihe Zhou, Julie Hawkins, Benjamin Fauber, Adam R. Johnson, Arunima Ganguli, Yuzhong Deng, Susan Summerhill, Kirk Robarge, Celine Eidenschenk, Wenjun Ouyang, Christine Everett, Jianhua Cao, Wei Tang, Hank La, Alberto Gobbi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2907-2912
The nuclear receptor (NR) retinoic acid receptor-related orphan receptor gamma (RORγ, RORc, or NR1F3) is a promising target for the treatment of autoimmune diseases. RORc is a critical regulator in the production of the pro-inflammatory cytokine int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9c3898f9ddd336ebaff802da33874c
https://doi.org/10.1016/j.bmcl.2015.05.055
https://doi.org/10.1016/j.bmcl.2015.05.055
Autor:
Adam R. Johnson, Justin Lesch, Christine Everett, Harvey Wong, Susan Summerhill, Peter Lockey, Arunima Ganguli, Julie Hawkins, Benjamin Fauber, Jason DeVoss, Olivier Rene, Maxine Norman, Hank La, Yuzhong Deng, Celine Eidenschenk, Wenjun Ouyang, Alberto Gobbi
Publikováno v:
Journal of Medicinal Chemistry. 58:5308-5322
Retinoic acid receptor-related orphan receptor C (RORc, RORγ, or NR1F3) is a nuclear receptor that plays a major role in the production of interleukin (IL)-17. Considerable efforts have been directed toward the discovery of selective RORc inverse ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151b339a4b74d195a593caace65f3802
https://doi.org/10.1021/acs.jmedchem.5b00597
https://doi.org/10.1021/acs.jmedchem.5b00597
Autor:
Arunima Ganguli, Iona Evans, Richard G. Black, Rod Smallwood, Ian R. Palmer, Lin Yang, Eva E. Qwarnstrom, Linda Persson
Publikováno v:
Circulation Research. 96:626-634
NF-kappaB, a transcription factor central to inflammatory regulation during development of atherosclerosis, is activated by soluble mediators and through biomechanical inputs such as flow-mediated shear- stress. To investigate the molecular mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0c3017cf12c1505da87e3470c6ce83
https://doi.org/10.1161/01.res.0000160435.83210.95
https://doi.org/10.1161/01.res.0000160435.83210.95
Autor:
Harvey Wong, Arunima Ganguli, Peter Lockey, Monique Bodil Van Niel, James R. Kiefer, Jonathan C. Killen, Julie Hawkins, Hank La, Nicole Wakes, Adam R. Johnson, Alberto Gobbi, Ann Qin, Celine Eidenschenk, Bohdan Waszkowycz, Benjamin Fauber, Wenjun Ouyang, Stuart Ward, Gladys de Leon Boenig, Emanuela Gancia, Simon Gaines, Christine Everett, Matthew W. Cartwright, Olivier Rene, Yuzhong Deng, Maxine Norman
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(24)
The identification of a new series of RORc inverse agonists is described. Comprehensive structure-activity relationship studies of this reversed sulfonamide series identified potent RORc inverse agonists in biochemical and cellular assays which were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd399101e2f58aa3b7b00e1280cd1f75
https://pubmed.ncbi.nlm.nih.gov/25453817
https://pubmed.ncbi.nlm.nih.gov/25453817
Autor:
Benjamin P. Fauber, Olivier René, Yuzhong Deng, Jason DeVoss, Céline Eidenschenk, Christine Everett, Arunima Ganguli, Alberto Gobbi, Julie Hawkins, AdamR. Johnson, Hank La, Justin Lesch, Peter Lockey, Maxine Norman, Wenjun Ouyang, Susan Summerhill, Harvey Wong
Publikováno v:
Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 13, p5308-5322, 15p