Výsledky vyhledávání - "Arungundrum S. Prakash"

The in vitro cytotoxicity and DNA alkylating ability of the simplest functional analogues of the seco CC-1065 alkylating subunit

Autor: Peter G. Parsons, Rodney H. White, David J. Young, Arungundrum S. Prakash

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:1869-1874

The p-hydroxyphenethyl halides 1(b-d) possess the minimum structural requirements for alkylating DNA with Ar-3′ participation and exhibit in vitro cytotoxicity and DNA alkylating ability/sequence selectivity which is diminished relative to more fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68f7bf57ecb548730891e4b10a74ad26
https://doi.org/10.1016/0960-894x(95)00310-p

Zobrazit plný text záznamu

Mutagenicity and DNA damage studies of N-acyloxy-N-alkoxyamides--the role of electrophilic nitrogen

Autor: Tony M, Banks, Antonio M, Bonin, Stephen A, Glover, Arungundrum S, Prakash

Publikováno v: Organicbiomolecular chemistry. 1(13)

N-Acyloxy-N-alkoxyamides are anomeric amides that are direct-acting mutagens. They have been shown to damage DNA in the major and the minor grooves in a pH and sequence-selective manner. In acidic media, they damage adenines at N3 in the minor groove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec21d65cefc8e898e414abe786cb138b
https://pubmed.ncbi.nlm.nih.gov/12945693

Zobrazit plný text záznamu

Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamides

Autor: Laurence P. G. Wakelin, A. Adams, William A. Denny, Arungundrum S. Prakash, J. Mitchell Guss, Charles A. Collyer

Publikováno v: Molecular pharmacology. 58(3)

For a series of antitumor-active 5-substituted 9-aminoacridine-4-carboxamide topoisomerase II poisons, we have used X-ray crystallography and stopped-flow spectrophotometry to explore relationships between DNA binding kinetics, biological activity, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b514b20edfdb86583216ed693f8c19f
https://pubmed.ncbi.nlm.nih.gov/10953060

Zobrazit plný text záznamu

Stability and DNA alkylation rates of the simplest functional analogues of CC-1065, para-hydroxy and para-amino phenethyl bromides

Autor: David J. Young, Gregory Blanch, Robyn L. Shalders, Christopher L. Brown, Arungundrum S. Prakash

Publikováno v: ResearcherID

We have recently synthesised a series of compounds based on the simplest functional unit of CC-1065 containing a para substituted phenethyl halide moiety. These compounds alkylate N3 of adenines in a similar fashion to CC-1065, as well as N7 of guani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c852bf99f0a8e940b6762f4210042f
https://pubmed.ncbi.nlm.nih.gov/10190546

Zobrazit plný text záznamu

Mechanism of action of fotemustine, a new chloroethylnitrosourea anticancer agent: evidence for the formation of two DNA-reactive intermediates contributing to cytotoxicity

Autor: Peter G. Parsons, Geoff Eaglesham, Mark T. Hayes, John Bartley, Arungundrum S. Prakash

Publikováno v: Biochemistry. 36(35)

Methyl excision repair deficient human tumor cells (Mer-) were found to be hypersusceptible to killing by the antimelanoma agent fotemustine (FM) implicating alkylation of O6 guanine as the major contributor to toxicity. Preincubation of the drug in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ae4f0583815c1d869e908953039fbb
https://pubmed.ncbi.nlm.nih.gov/9271495

Zobrazit plný text záznamu

Enzymatic and chemical footprinting of anthracycline antitumor antibiotics and related saccharide side chains

Autor: Cathryn J. Shelton, Arungundrum S. Prakash, Margaret M. Harding

Publikováno v: Biochemistry. 35(24)

DNase I and three DNA chemical footprinting agents were used to compare the DNA binding properties of the anthracycline antitumor antibiotics daunomycin, aclacinomycin A, and ditrisarubicin B. These anthracyclines contain a tetracyclic chromophore wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c755d05805b87195e84af4e158210a2e
https://pubmed.ncbi.nlm.nih.gov/8672501

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání