Výsledky vyhledávání - "Arundhathi Venkatasubramaniam"

Akademický článek

Dry and liquid formulations of IBT-V02, a novel multi-component toxoid vaccine, are effective against Staphylococcus aureus isolates from low-to-middle income countries

Autor: Yu Wang, Ipsita Mukherjee, Arundhathi Venkatasubramaniam, Dustin Dikeman, Nicholas Orlando, Jing Zhang, Roger Ortines, Mark Mednikov, Shardulendra P. Sherchand, Tulasikumari Kanipakala, Thao Le, Sanjay Shukla, Mark Ketner, Rajan P. Adhikari, Hatice Karauzum, M. Javad Aman, Nathan K. Archer

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs) in the U.S. as well as more serious invasive diseases, including bacteremia, sepsis, endocarditis, surgical site infections, osteomyelitis, and pneumonia. These inf

Externí odkaz: https://doaj.org/article/9e8670e1737d41c3b9440e011a2c6162

Zobrazit plný text záznamu

Akademický článek

IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus

Autor: Hatice Karauzum, Arundhathi Venkatasubramaniam, Rajan P. Adhikari, Tom Kort, Frederick W. Holtsberg, Ipsita Mukherjee, Mark Mednikov, Roger Ortines, Nhu T. Q. Nguyen, Thien M. N. Doan, Binh An Diep, Jean C. Lee, M. Javad Aman

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Staphylococcus aureus causes a wide range of diseases from skin infections to life threatening invasive diseases such as bacteremia, endocarditis, pneumonia, surgical site infections, and osteomyelitis. Skin infections such as furuncles, carbuncles,

Externí odkaz: https://doaj.org/article/5acc92f49b3f477d92f2e62b58561d28

Zobrazit plný text záznamu

Akademický článek

Safety and Immunogenicity of a 4-Component Toxoid-Based Staphylococcus aureus Vaccine in Rhesus Macaques

Autor: Arundhathi Venkatasubramaniam, Grant Liao, Eunice Cho, Rajan P. Adhikari, Tom Kort, Frederick W. Holtsberg, Karen E. Elsass, Dean J. Kobs, Thomas L. Rudge, Keith D. Kauffman, Nickiana E. Lora, Daniel L. Barber, M. Javad Aman, Hatice Karauzum

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Staphylococcus aureus is a leading cause of significant morbidity and mortality and an enormous economic burden to public health worldwide. Infections caused by methicillin-resistant S. aureus (MRSA) pose a major threat as MRSA strains are becoming i

Externí odkaz: https://doaj.org/article/c83a2f964899456781ac389d4bee43fb

Zobrazit plný text záznamu

Akademický článek

Rational Design of Toxoid Vaccine Candidates for Staphylococcus aureus Leukocidin AB (LukAB)

Autor: Shweta Kailasan, Thomas Kort, Ipsita Mukherjee, Grant C. Liao, Tulasikumari Kanipakala, Nils Williston, Nader Ganjbaksh, Arundhathi Venkatasubramaniam, Frederick W. Holtsberg, Hatice Karauzum, Rajan P. Adhikari, M. Javad Aman

Publikováno v: Toxins, Vol 11, Iss 6, p 339 (2019)

Staphylococcus aureus (SA) infections cause high mortality and morbidity in humans. Being central to its pathogenesis, S. aureus thwarts the host defense by secreting a myriad of virulence factors, including bicomponent, pore-forming leukotoxins. Whi

Externí odkaz: https://doaj.org/article/c6f398503f794613afe09b6beeb975f9

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

A Critical Role for HlgA in Staphylococcus aureus Pathogenesis Revealed by A Switch in the SaeRS Two-Component Regulatory System

Autor: Arundhathi Venkatasubramaniam, Tulasikumari Kanipakala, Nader Ganjbaksh, Rana Mehr, Ipsita Mukherjee, Subramaniam Krishnan, Taeok Bae, M. Javad Aman, Rajan P. Adhikari

Publikováno v: Toxins, Vol 10, Iss 9, p 377 (2018)

Cytolytic pore-forming toxins including alpha hemolysin (Hla) and bicomponent leukotoxins play an important role in the pathogenesis of Staphylococcus aureus. These toxins kill the polymorphonuclear phagocytes (PMNs), disrupt epithelial and endotheli

Externí odkaz: https://doaj.org/article/01773acd6cfc48c680475e846cd4cf50

Zobrazit plný text záznamu

Plný text ve formátu HTML

Efficacy of Active Immunization With Attenuated α-Hemolysin and Panton-Valentine Leukocidin in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia

Autor: Erika Schneider-Smith, Vien T. M. Le, Xing Wang, M. Javad Aman, Arundhathi Venkatasubramaniam, Trang Vu, Binh An Diep, Hoan N. Le, Vuvi G. Tran, Subramaniam Krishnan, Rajan P. Adhikari

Publikováno v: J Infect Dis

Staphylococcus aureus is a common pathogen causing infections in humans with various degrees of severity, with pneumonia being one of the most severe infections. In as much as staphylococcal pneumonia is a disease driven in large part by α-hemolysin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6f8bbd4baaac324f88f4579bbf9738
https://doi.org/10.1093/infdis/jiz437

Zobrazit plný text záznamu