Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Arunasalam Naguleswaran"'
Autor:
Marina Maurizio, Maria Masid, Kerry Woods, Reto Caldelari, John G. Doench, Arunasalam Naguleswaran, Denis Joly, Martín González-Fernández, Jonas Zemp, Mélanie Borteele, Vassily Hatzimanikatis, Volker Heussler, Sven Rottenberg, Philipp Olias
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Parasitic diseases, particularly malaria (caused by Plasmodium falciparum) and theileriosis (caused by Theileria spp.), profoundly impact global health and the socioeconomic well-being of lower-income countries. Despite recent advances, iden
Externí odkaz:
https://doaj.org/article/6b4b2ca83d7b4ebaa7f6f50164e555c9
Autor:
Francis Brühlmann, Carmen Perry, Charlotte Griessen, Kapila Gunasekera, Jean-Louis Reymond, Arunasalam Naguleswaran, Sven Rottenberg, Kerry Woods, Philipp Olias
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Theileria annulata is a tick-transmitted apicomplexan parasite that gained the unique ability among parasitic eukaryotes to transform its host cell, inducing a fatal cancer-like disease in cattle. Understanding the mechanistic interplay betw
Externí odkaz:
https://doaj.org/article/924773a3875445f2b36439c63290d308
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Developmental regulation of mitochondrial uridine insertion/deletion editing in Trypanosoma brucei is necessary to modulate parasite metabolism as it shifts from dependence on glycolysis for ATP production in the mammalian bloodstream form (
Externí odkaz:
https://doaj.org/article/01f5329e6f9e41f6add10b90b179be75
Autor:
Sebastian Shaw, Sebastian Knüsel, Daniel Abbühl, Arunasalam Naguleswaran, Ruth Etzensperger, Mattias Benninger, Isabel Roditi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
African trypanosomes collectively move in a process called social motility. Here, the authors show that procyclic forms acidify their environment as a consequence of glucose metabolism, generating pH gradients by diffusion that are sensed via cyclic
Externí odkaz:
https://doaj.org/article/1360a9650cc043f4bd6369e9b115cd99
Autor:
Ranjan Ramasamy, Vaikunthavasan Thiruchenthooran, Tibutius T. P. Jayadas, Thampoe Eswaramohan, Sharanga Santhirasegaram, Kokila Sivabalakrishnan, Arunasalam Naguleswaran, Marilyne Uzest, Bastien Cayrol, Sebastien N. Voisin, Philippe Bulet, Sinnathamby N. Surendran
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background Aedes aegypti mosquito, the principal global vector of arboviral diseases, lays eggs and undergoes larval and pupal development to become adult mosquitoes in fresh water (FW). It has recently been observed to develop in coastal br
Externí odkaz:
https://doaj.org/article/a7820071c63544a6aaedfa213ac49f15
Autor:
Arunasalam Naguleswaran, Paula Fernandes, Shubha Bevkal, Ruth Rehmann, Pamela Nicholson, Isabel Roditi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009504 (2021)
Trypanosoma brucei ssp., unicellular parasites causing human and animal trypanosomiasis, are transmitted between mammals by tsetse flies. Periodic changes in variant surface glycoproteins (VSG), which form the parasite coat in the mammal, allow them
Externí odkaz:
https://doaj.org/article/10ad374d0e6749e0a2ce73fcf1e8ef83
Autor:
Shubha Bevkal, Arunasalam Naguleswaran, Ruth Rehmann, Marcel Kaiser, Manfred Heller, Isabel Roditi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009239 (2021)
The transition between hosts is a challenge for digenetic parasites as it is unpredictable. For Trypanosoma brucei subspecies, which are disseminated by tsetse flies, adaptation to the new host requires differentiation of stumpy forms picked up from
Externí odkaz:
https://doaj.org/article/ee0ae78a0c3649a9bd2e2de1623db7ac
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Trypanosoma brucei brucei, the parasite causing Nagana in domestic animals, is closely related to the parasites causing sleeping sickness, but does not infect humans. In addition to its importance as a pathogen, the relative ease
Externí odkaz:
https://doaj.org/article/21dca15a872b43a3bffc2836a067f4f5
Autor:
Arunasalam Naguleswaran, Kapila Gunasekera, Bernd Schimanski, Manfred Heller, Andrew Hemphill, Torsten Ochsenreiter, Isabel Roditi
Publikováno v:
mBio, Vol 6, Iss 2 (2015)
ABSTRACT TbRRM1 of Trypanosoma brucei is a nucleoprotein that was previously identified in a search for splicing factors in T. brucei. We show that TbRRM1 associates with mRNAs and with the auxiliary splicing factor polypyrimidine tract-binding prote
Externí odkaz:
https://doaj.org/article/da0b481d64e14f18bf26068751de0ed7
Autor:
Arunasalam Naguleswaran, Eliana V Elias, Jeanette McClintick, Howard J Edenberg, William J Sullivan
Publikováno v:
PLoS Pathogens, Vol 6, Iss 12, p e1001232 (2010)
Parasitic protozoa such as the apicomplexan Toxoplasma gondii progress through their life cycle in response to stimuli in the environment or host organism. Very little is known about how proliferating tachyzoites reprogram their expressed genome in r
Externí odkaz:
https://doaj.org/article/cc7a2460103a4c898792691bfabd93b8