A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates.

Autor: Arunachalam PS; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA., Ha N; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA., Dennison SM; Center for Human Systems Immunology, Department of Surgery, Duke University, Durham, NC 27701, USA., Spreng RL; Center for Human Systems Immunology, Department of Surgery, Duke University, Durham, NC 27701, USA.; Duke Human Vaccine Institute, Duke University, Durham, NC 27703, USA., Seaton KE; Center for Human Systems Immunology, Department of Surgery, Duke University, Durham, NC 27701, USA., Xiao P; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Feng Y; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA., Zarnitsyna VI; Department of Microbiology and Immunology, Emory University, Atlanta, GA 30329, USA., Kazmin D; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA., Hu M; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA., Santagata JM; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA., Xie X; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA., Rogers K; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Shirreff LM; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Chottin C; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Spencer AJ; The Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK., Dutta S; Structural Vaccinology Laboratory, Biologics Research and Development Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA., Prieto K; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., Julien JP; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.; Departments of Biochemistry and Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada., Tomai M; Solventum, Saint Paul, MN 55144, USA., Fox CB; Access to Advanced Health Institute (AAHI), Seattle, WA 98102, USA., Villinger F; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Hill AVS; The Jenner Institute, University of Oxford, Oxford, OX3 7DQ, UK., Tomaras GD; Center for Human Systems Immunology, Department of Surgery, Duke University, Durham, NC 27701, USA.; Duke Human Vaccine Institute, Duke University, Durham, NC 27703, USA., Pulendran B; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA.; Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA 94305, USA.; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Jul 31; Vol. 16 (758), pp. eadn6605. Date of Electronic Publication: 2024 Jul 31.

Impaired innate and adaptive immune responses to BNT162b2 SARS-CoV-2 vaccination in systemic lupus erythematosus.

Autor: Sarin KY; Department of Dermatology., Zheng H; Institute for Immunity, Transplantation and Infection.; Center for Biomedical Informatics Research, Department of Medicine, School of Medicine, and., Chaichian Y; Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA., Arunachalam PS; Institute for Immunity, Transplantation and Infection.; Department of Immunobiology, University of Arizona, Tucson, Arizona, USA., Swaminathan G; Department of Dermatology., Eschholz A; Department of Dermatology., Gao F; Institute for Immunity, Transplantation and Infection., Wirz OF; Department of Pathology and., Lam B; Department of Pathology and., Yang E; Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA., Lee LW; Department of Pediatrics, Division of Pediatric Pulmonary Medicine, Stanford University School of Medicine, Stanford, California, USA., Feng A; Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA., Lewis MA; Department of Dermatology., Lin J; Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA., Maecker HT; Institute for Immunity, Transplantation and Infection., Boyd SD; Department of Pathology and., Davis MM; Institute for Immunity, Transplantation and Infection.; Department of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford University, Stanford, California, USA., Nadeau KC; Institute for Immunity, Transplantation and Infection.; Department of Environmental Gealth, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Pulendran B; Department of Pathology and.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, California, USA., Khatri P; Institute for Immunity, Transplantation and Infection.; Center for Biomedical Informatics Research, Department of Medicine, School of Medicine, and., Utz PJ; Institute for Immunity, Transplantation and Infection.; Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA., Zaba LC; Department of Dermatology.

Publikováno v: JCI insight [JCI Insight] 2024 Mar 08; Vol. 9 (5). Date of Electronic Publication: 2024 Mar 08.

Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth.

Autor: Wimmers F; Department of Molecular Medicine, Interfaculty Institute for Biochemistry, University of Tuebingen, 72076 Tuebingen, Baden-Wuerttemberg, Germany; DFG Cluster of Excellence 2180 'Image-guided and Functional Instructed Tumor Therapy' (iFIT), University of Tuebingen, 72076 Tuebingen, Baden-Wuerttemberg, Germany; German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Baden-Wuerttemberg, Germany., Burrell AR; Department of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Environmental and Public Health Sciences, Division of Epidemiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Feng Y; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA., Zheng H; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305, USA., Arunachalam PS; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA., Hu M; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA., Spranger S; Department of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Nyhoff LE; Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA., Joshi D; Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA., Trisal M; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA., Awasthi M; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA., Bellusci L; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA., Ashraf U; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA., Kowli S; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA., Konvinse KC; Department of Pediatrics, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA., Yang E; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Blanco M; Stanford Genomics Service Center, Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Pellegrini K; Yerkes National Primate Research Center, Atlanta, GA 30024, USA., Tharp G; Yerkes National Primate Research Center, Atlanta, GA 30024, USA., Hagan T; Department of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Chinthrajah RS; Department of Medicine, Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA., Nguyen TT; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA., Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA., Nadeau KC; Department of Medicine, Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA., Haslam DB; Department of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Bosinger SE; Yerkes National Primate Research Center, Atlanta, GA 30024, USA; Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA., Wrammert J; Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA., Maecker HT; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA., Utz PJ; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Wang TT; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA., Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA., Khatri P; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA 94305, USA., Staat MA; Department of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Pulendran B; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: bpulend@stanford.edu.

Publikováno v: Cell [Cell] 2023 Oct 12; Vol. 186 (21), pp. 4632-4651.e23. Date of Electronic Publication: 2023 Sep 29.

Addendum: Systems vaccinology of the BNT162b2 mRNA vaccine in humans.

Autor: Arunachalam PS; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Scott MKD; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.; Center for Biomedical Informatics, Department of Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Hagan T; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Li C; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Feng Y; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Wimmers F; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Grigoryan L; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Trisal M; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Edara VV; Yerkes National Primate Research Center, Atlanta, GA, USA., Lai L; Yerkes National Primate Research Center, Atlanta, GA, USA., Chang SE; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Feng A; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Dhingra S; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Shah M; Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA., Lee AS; Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA., Chinthrajah S; Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA., Sindher SB; Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA., Mallajosyula V; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Gao F; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Sigal N; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Kowli S; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Gupta S; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Pellegrini K; Yerkes National Primate Research Center, Atlanta, GA, USA., Tharp G; Yerkes National Primate Research Center, Atlanta, GA, USA., Maysel-Auslender S; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Hamilton S; Yerkes National Primate Research Center, Atlanta, GA, USA., Aoued H; Yerkes National Primate Research Center, Atlanta, GA, USA., Hrusovsky K; Quanterix, Billerica, MA, USA., Roskey M; Quanterix, Billerica, MA, USA., Bosinger SE; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA., Maecker HT; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA., Boyd SD; Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Davis MM; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Utz PJ; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., Suthar MS; Yerkes National Primate Research Center, Atlanta, GA, USA., Khatri P; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA. pkhatri@stanford.edu.; Center for Biomedical Informatics, Department of Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. pkhatri@stanford.edu., Nadeau KC; Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Stanford, CA, USA. knadeau@stanford.edu.; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. knadeau@stanford.edu.; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. knadeau@stanford.edu., Pulendran B; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.

Publikováno v: Nature [Nature] 2023 Jun; Vol. 618 (7964), pp. E18.

Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine.

Autor: Feng Y; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA., Yuan M; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Powers JM; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Hu M; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA., Munt JE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Arunachalam PS; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA., Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Bellusci L; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration (FDA), Silver Spring, MD 20993, USA., Kim J; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration (FDA), Silver Spring, MD 20993, USA., Sprouse KR; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Adams LE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Sundaramurthy S; Sino Biological US Inc., Wayne, PA 19087, USA., Zhu X; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Shirreff LM; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Mallory ML; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Scobey TD; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Moreno A; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., O'Hagan DT; GSK, Rockville, MD 20850, USA., Kleanthous H; Bill and Melinda Gates Foundation, Seattle, WA 98109, USA., Villinger FJ; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., King NP; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Suthar MS; Department of Pediatrics, Emory Vaccine Center, Emory National Primate Research Center, Atlanta, GA 30329, USA., Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration (FDA), Silver Spring, MD 20993, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Wilson IA; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Pulendran B; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 May 10; Vol. 15 (695), pp. eadg7404. Date of Electronic Publication: 2023 May 10.