Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Aruna Sampath"'
Autor:
Michael Callahan, Anthony M Treston, Grace Lin, Marla Smith, Brian Kaufman, Mansoora Khaliq, Lisa Evans DeWald, Kevin Spurgers, Kelly L Warfield, Preeya Lowe, Matthew Duchars, Aruna Sampath, Urban Ramstedt
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010636 (2022)
BackgroundUV-4 (N-(9'-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate with in vitro antiviral activity against diverse viruses including dengue, influenza, and filoviruses and demonstrated in
Externí odkaz:
https://doaj.org/article/1b9a38644e1447e182ac97752d59a1a1
Autor:
Kelly L. Warfield, Emily Plummer, Dominic S. Alonzi, Gary W. Wolfe, Aruna Sampath, Tam Nguyen, Terry D. Butters, Sven G. Enterlein, Eric J. Stavale, Sujan Shresta, Urban Ramstedt
Publikováno v:
Viruses, Vol 7, Iss 5, Pp 2404-2427 (2015)
Iminosugars are capable of targeting the life cycles of multiple viruses by blocking host endoplasmic reticulum α-glucosidase enzymes that are required for competent replication of a variety of enveloped, glycosylated viruses. Iminosugars as a class
Externí odkaz:
https://doaj.org/article/f44baf4e0c47464bb4f5548930981c85
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121662 (2015)
Our lead iminosugar analog called UV-4 or N-(9-methoxynonyl)-1-deoxynojirimycin inhibits activity of endoplasmic reticulum (ER) α-glucosidases I and II and is a potent, host-targeted antiviral candidate. The mechanism of action for the antiviral act
Externí odkaz:
https://doaj.org/article/4f9b09d8e76441a9acde7d815c930f92
Autor:
Kelly L. Warfield, Dale L. Barnard, Sven G. Enterlein, Donald F. Smee, Mansoora Khaliq, Aruna Sampath, Michael V. Callahan, Urban Ramstedt, Craig W. Day
Publikováno v:
Viruses, Vol 8, Iss 3, p 71 (2016)
Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection aga
Externí odkaz:
https://doaj.org/article/aed3cb696ffc407f90fd4a3af2491ffb
Publikováno v:
Research Journal of Textile and Apparel, 2021, Vol. 26, Issue 1, pp. 73-89.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/RJTA-06-2020-0063
Autor:
Jeffry, Shearer, Gary, Wolfe, Mansoora, Khaliq, Brian, Kaufman, Aruna, Sampath, Kelly L, Warfield, Urban, Ramstedt, Anthony, Treston
Publikováno v:
Reproductive Toxicology. 114:9-21
UV-4 (N-(9-methoxynonyl)-1-deoxynojirimycin) is a host-targeted antiviral agent, which targets mammalian proteins (endoplasmic reticulum glucosidases) rather than virally encoded proteins. This mechanism confers both broad-spectrum activity and low p
Autor:
Jeffry Shearer, Gary Wolfe, Aruna Sampath, Kelly L Warfield, Brian Kaufman, Urban Ramstedt, Anthony Treston
Publikováno v:
Int J Toxicol
UV-4 (N-(9-methoxynonyl)-1-deoxynojirimycin) is a broad-spectrum antiviral drug candidate with demonstrated activity in vitro and in vivo against multiple, diverse viruses. Nonclinical safety pharmacology studies were conducted to support the filing
Autor:
Jeffry Shearer, Gary Wolfe, Aruna Sampath, Kelly L. Warfield, Brian Kaufman, Urban Ramstedt, Anthony Treston
Publikováno v:
International journal of toxicology. 41(3)
The iminosugar UV-4 is a broad-spectrum antiviral drug candidate with activity in vitro and in vivo against multiple, diverse viruses. The toxicological profile of UV-4, dosed as the hydrochloride salt, was evaluated in single-dose and repeat-dose or
Akademický článek
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Autor:
Mengxi Yang, Kangyu Deng, Wijerath Wiriduge Hasitha Aruna Sampath, Kangsen Mai, Wenbing Zhang, Yue Zhang, Mingzhu Pan
Publikováno v:
Aquaculture Nutrition. 26:516-527
Japanese flounder juveniles (initial body weight: 7.12 ± 0.02 g) were fed three diets containing 0, 120 and 200 g/kg of carbohydrates (C0, C120 and C200, respectively) for 10 weeks. Results showed that higher dietary carbohydrate intake enabled furt