Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Aruna S. Jaiswal"'
Autor:
Jac A. Nickoloff, Aruna S. Jaiswal, Neelam Sharma, Elizabeth A. Williamson, Manh T. Tran, Dominic Arris, Ming Yang, Robert Hromas
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16903 (2023)
Replicative DNA polymerases are blocked by nearly all types of DNA damage. The resulting DNA replication stress threatens genome stability. DNA replication stress is also caused by depletion of nucleotide pools, DNA polymerase inhibitors, and DNA seq
Externí odkaz:
https://doaj.org/article/7e25cda77ab842a49e99ec5ff49c7538
Autor:
Aruna S. Jaiswal, Harekrushna Panda, Christine A. Pampo, Dietmar W. Siemann, C. Gary Gairola, Robert Hromas, Satya Narayan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 4, Pp 454-460 (2013)
Adenomatous polyposis coli (APC) is a multifunctional protein having diverse cellular functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal segregation, and apoptosis. Recently, we found a new role of APC in base exc
Externí odkaz:
https://doaj.org/article/7dd6713af332447ea01cd8920856ac45
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 6, Pp 495-508 (2012)
In previous studies, we found that adenomatous polyposis coli (APC) blocks the base excision repair (BER) pathway by interacting with 5′-flap endonuclease 1 (Fen1). In this study, we identify the molecular features that contribute to the formation
Externí odkaz:
https://doaj.org/article/91affa55d05f4d979a0578d0c456dfae
Autor:
Satya Narayan, David A. Ostrov, Fazlul H. Sarkar, Tadahide Izumi, Charles D. Bulkin, Harekrushna Panda, Sanjeev Banerjee, Aruna S. Jaiswal
The recent emerging concept to sensitize cancer cells to DNA-alkylating drugs is by inhibiting various proteins in the base excision repair (BER) pathway. In the present study, we used structure-based molecular docking of DNA polymerase β (Pol-β) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce6ed2a01e96dd4859ec5de5fdc9c94
https://doi.org/10.1158/1541-7786.c.6541951
https://doi.org/10.1158/1541-7786.c.6541951
Autor:
Satya Narayan, David A. Ostrov, Fazlul H. Sarkar, Tadahide Izumi, Charles D. Bulkin, Harekrushna Panda, Sanjeev Banerjee, Aruna S. Jaiswal
Supplementary Data from A Novel Inhibitor of DNA Polymerase β Enhances the Ability of Temozolomide to Impair the Growth of Colon Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cdba46818a1c590313624ee9f587fc8
https://doi.org/10.1158/1541-7786.22518502.v1
https://doi.org/10.1158/1541-7786.22518502.v1
Autor:
Aruna S Jaiswal, Hyun-Suk Kim, Orlando D Schärer, Neelam Sharma, Elizabeth A Williamson, Gayathri Srinivasan, Linda Phillips, Kimi Kong, Shailee Arya, Anurag Misra, Arijit Dutta, Yogesh Gupta, Christi A Walter, Sandeep Burma, Satya Narayan, Patrick Sung, Jac A Nickoloff, Robert Hromas
Publikováno v:
NAR Cancer. 5
Unrepaired oxidatively-stressed replication forks can lead to chromosomal instability and neoplastic transformation or cell death. To meet these challenges cells have evolved a robust mechanism to repair oxidative genomic DNA damage through the base
Autor:
Aruna S Jaiswal, Harekrushna Panda, Brian K Law, Jay Sharma, Jitesh Jani, Robert Hromas, Satya Narayan
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0123808 (2015)
Recently approved chemotherapeutic agents to treat colorectal cancer (CRC) have made some impact; however, there is an urgent need for newer targeted agents and strategies to circumvent CRC growth and metastasis. CRC frequently exhibits natural resis
Externí odkaz:
https://doaj.org/article/3b8a9548c8d241ad8db91c71367d1dbb
Autor:
Hal E. Broxmeyer, Elizabeth A. Williamson, Sarah C. Glover, Austin Kirby, Yilianys Pride, Maegan L. Capitano, Aruna S. Jaiswal, Gayathri Srinivasan, Daniel D Mais, Robert Hromas, Fatemah G. Amlashi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0252805 (2021)
PLoS ONE, Vol 16, Iss 7, p e0252805 (2021)
Chemokines are small proteins that promote leukocyte migration during development, infection, and inflammation. We and others isolated the unique chemokine CCL21, a potent chemo-attractant for naïve T-cells, naïve B-cells, and immature dendritic ce
Autor:
Elizabeth A. Williamson, Weixing Zhao, Kimi Kong, Orlando D. Schärer, Sandeep Burma, Hyunsuk Kim, Patrick Sung, Aruna S. Jaiswal, Guangcun Huang, Robert Hromas, Gayathri Srinivasan
Publikováno v:
Proceedings of the National Academy of Sciences. 116:17438-17443
Defects in DNA repair give rise to genomic instability, leading to neoplasia. Cancer cells defective in one DNA repair pathway can become reliant on remaining repair pathways for survival and proliferation. This attribute of cancer cells can be explo
Autor:
Srinivasa R. Ramisetti, Parvesh Singh, Shantu Amin, Arun Sharma, Brian K. Law, Ashona Singh-Pillay, Aruna S. Jaiswal, Satya Narayan
Publikováno v:
European Journal of Medicinal Chemistry
Despite new agent development and short-term benefits in patients with colorectal cancer (CRC), metastatic CRC cure rates have not improved due to high rates of 5-fluorouracil (5-FU)/leucovorin/oxaliplatin (FOLFOX)-resistance and a clinical therapeut