Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Aruna Railkar"'
Autor:
Huifeng Niu, David Heimbrook, Aruna Railkar, Jia Kui Li, Harpreet K. Sandhu, Petra Goelzer, Mei Liu, Nader Fotouhi, Nicholas Huby, John Moliterni, Christine Rizzo, Huisheng Wang, Kathryn Packman, Kenneth Kolinsky, Brian Higgins, Sherif Daouti
Supplementary Figures 1-2 from Preclinical In vivo Evaluation of Efficacy, Pharmacokinetics, and Pharmacodynamics of a Novel MEK1/2 Kinase Inhibitor RO5068760 in Multiple Tumor Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27a81b81845d3a1a9eea544506caaef
https://doi.org/10.1158/1535-7163.22484477.v1
https://doi.org/10.1158/1535-7163.22484477.v1
Autor:
Huifeng Niu, David Heimbrook, Aruna Railkar, Jia Kui Li, Harpreet K. Sandhu, Petra Goelzer, Mei Liu, Nader Fotouhi, Nicholas Huby, John Moliterni, Christine Rizzo, Huisheng Wang, Kathryn Packman, Kenneth Kolinsky, Brian Higgins, Sherif Daouti
Targeting the Ras/Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway represents a promising anticancer strategy. Recently, we have reported a novel class of potent and selective non–ATP-competitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f11847fc95e122e6d967121d5c49bd
https://doi.org/10.1158/1535-7163.c.6531425.v1
https://doi.org/10.1158/1535-7163.c.6531425.v1
Autor:
Harpreet Sandhu, Siva Ram Kiran Vaka, Dipen Desai, Paras Jariwala, Aruna Railkar, Wantanee Phuapradit, Navnit Shah
Publikováno v:
Oral Drug Delivery for Modified Release Formulations. :181-204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cae7f9d3eec6be376bbe44cddfdc0e68
https://doi.org/10.1002/9781119772729.ch10
https://doi.org/10.1002/9781119772729.ch10
Autor:
Peter Michael Wovkulich, Cheryl Janson, Hongmao Sun, Yang He, Rossman Pamela Loreen, Qing Xiang, Xiaolei Zhang, Zhi Chen, Qi Qiao, Romyr Dominique, Christine Lukacs, Kin-Chun Luk, Yi Chen, Kevin W. Anderson, Aruna Railkar, Kelli Glenn, Ann Polonskaia, Masha Vilenchik
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6610-6615
DYRK1B is a kinase over-expressed in certain cancer cells (including colon, ovarian, pancreatic, etc.). Recent publications have demonstrated inhibition of DYRK1B could be an attractive target for cancer therapy. From a data-mining effort, the team h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc5019acedd92e1f83d6b4a4d17562a
https://doi.org/10.1016/j.bmcl.2013.10.055
https://doi.org/10.1016/j.bmcl.2013.10.055
Autor:
Taygerly Joshua Paul Gergely, Eun Kyung Lee, Mcintosh Joel, Sarah C. Abbot, Jaehyeon Park, Sonal Rajyaguru, Yun-Chou Tan, Shalini Anand, Francisco Xavier Talamas, Sophie Le Pogam, Remy Lemoine, David S. Carter, Petra Inbar, Jun Chen, Leanna R. Staben, Armando G. Villaseñor, Javier de Vicente, Isabel Najera, Ryan Craig Schoenfeld, Leyi Gong, Seth F. Harris, Paul Weller, Sharada Shenvi Labadie, Ken A. Brameld, Aruna Railkar, Sangi Michael, Amy Fung, Jim Li, Vincent Leveque, Dana Davis
Publikováno v:
Journal of Medicinal Chemistry. 57:1914-1931
In the past few years, there have been many advances in the efforts to cure patients with hepatitis C virus (HCV). The ultimate goal of these efforts is to develop a combination therapy consisting of only direct-antiviral agents (DAAs). In this paper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8b3c89c500a0233782f42b5f71c4d4
https://doi.org/10.1021/jm401329s
https://doi.org/10.1021/jm401329s
Autor:
Nadine Tare, Gerry Kaplan, Aruna Railkar, Anjula Pamidimukkala, Karl Frank, Gary Cavallo, Duk Soon Choi, Louise Gerber, Louis M. Renzetti, Jianping Lou, Jefferson Wright Tilley, Achyutharao Sidduri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1036-1040
From a series of N-acyl 4-(3-pyridonyl)phenylalanine derivatives of 4, the trifluoromethyl derivative 28 was identified as a potent, dual acting alpha4 integrin antagonist with activity in primate models of allergic asthma. Investigation of a series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08c5a8da0eaac2bf6512608278d3b51
https://doi.org/10.1016/j.bmcl.2012.12.019
https://doi.org/10.1016/j.bmcl.2012.12.019
Autor:
Duk Soon Choi, Louise Gerber, Jianping Lou, Louis M. Renzetti, Karl Frank, Achyutharao Sidduri, Aruna Railkar, Anjula Pamidimukkala, Gary Cavallo, Jefferson Wright Tilley, Nadine Tare
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1026-1031
N-Acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives of type 4 were designed to replace the 2,6-dichlorobenzoylamine portion of compound 1 in order to identify novel compounds with improved potency against α4-integrins. Several derivatives we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b26e172df191cd396f104c96ab6eb0
https://doi.org/10.1016/j.bmcl.2012.12.026
https://doi.org/10.1016/j.bmcl.2012.12.026
Autor:
Joseph Grimsby, Robert Francis Kester, Aruna Railkar, Cheryl Spence, Nancy-Ellen Haynes, Kevin Richard Guertin, Paige Erin Mahaney, Lida Qi, John Tengi, Wendy Lea Corbett, Fred Thomas Bizzarro, Mark T. Dvorozniak, George W. Holland, Joseph F. Grippo, Franz M. Matschinsky, Darryl W. Hilliard, Ramakanth Sarabu
Publikováno v:
Journal of Medicinal Chemistry. 53:3618-3625
Glucokinase (GK) is a glucose sensor that couples glucose metabolism to insulin release. The important role of GK in maintaining glucose homeostasis is illustrated in patients with GK mutations. In this publication, identification of the hit molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b04c9f71b7dc5668c9b393926609d9
https://doi.org/10.1021/jm100039a
https://doi.org/10.1021/jm100039a
Autor:
Zhuming Zhang, Melissa Smith, Navita L. Mallalieu, Omar Jose Morales, Kin-Chun Luk, Lee Apostle Mcdermott, Jia K. Li, Tom Flynn, Yi Chen, Brian Higgins, June Ke, Jin-Jun Liu, Hong Yang, Fred Konzelmann, Mary Simcox, Tom Nevins, Thomas Egan, Yingsi Chen, Kenneth Kolinsky, Louise Gerber, Aruna Railkar, Stan Kolis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1950-1953
RO4396686 is a small molecule KDR, FGFR, and PDGFR inhibitor with good pharmacokinetic properties in rodents. In a mouse corneal neovascularization assay, this compound inhibited VEGF-induced angiogenesis. Tested in a H460a xenograft tumor model this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9e17ce43056e160291c9e5b5ce543e
https://doi.org/10.1016/j.bmcl.2005.12.092
https://doi.org/10.1016/j.bmcl.2005.12.092
Autor:
Navita L. Mallalieu, Hong Yang, Mary Simcox, Jia K. Li, Kin-Chun Luk, Thomas Egan, Tom Nevins, Melissa Smith, Kenneth Kolinsky, Yingsi Chen, Brian Higgins, Aruna Railkar, Stan Kolis, Lee Apostle Mcdermott, Louise Gerber, June Ke
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:4835-4841
(±)-1-(anti-3-Hydroxy-cyclopentyl)-3-(4-methoxy-phenyl)-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one (RO4383596) is a potent and selective inhibitor of the pro-angiogenic receptor tyrosine kinases KDR, FGFR, and PDGFR. This agent has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4cc41f934537437620a6abb9bf3335
https://doi.org/10.1016/j.bmc.2005.05.012
https://doi.org/10.1016/j.bmc.2005.05.012