Zobrazeno 1 - 5
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pro vyhledávání: '"Aruna Purohit"'
Publikováno v:
The Journal of Cell Biology
Pericentrin is a conserved protein of the centrosome involved in microtubule organization. To better understand pericentrin function, we overexpressed the protein in somatic cells and assayed for changes in the composition and function of mitotic spi
Autor:
Brian J. Burke, Roger Craig, Aruna Purohit, Stephen J. Doxsey, Peter Lawrence Bangs, Christine M. Powers
Publikováno v:
The Journal of Cell Biology
Tpr is a 270-kD coiled-coil protein localized to intranuclear filaments of the nuclear pore complex (NPC). The mechanism by which Tpr contributes to the structure and function of the nuclear pore is currently unknown. To gain insight into Tpr functio
Publikováno v:
The Journal of biological chemistry. 279(6)
Location is a critical determinant in dictating the cellular function of protein kinase C (PKC). Scaffold proteins contribute to localization by poising PKC at specific intracellular sites. Using a yeast two-hybrid screen, we identified the centrosom
Publisher Summary This chapter describes methods that can be used to examine the distribution, assembly, isolation, and function of pericentrin. Pericentrin is a reliable marker for centrosomes and acentriolar microtubule organizing center (MTOCs) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e3e11ee581c11a9e31c25624b9cdd07
https://doi.org/10.1016/s0091-679x(01)67005-5
https://doi.org/10.1016/s0091-679x(01)67005-5
Publikováno v:
Molecular biology of the cell. 11(6)
Centrosome assembly is important for mitotic spindle formation and if defective may contribute to genomic instability in cancer. Here we show that in somatic cells centrosome assembly of two proteins involved in microtubule nucleation, pericentrin an