Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Aruna B. Wijeratne"'
Autor:
Pablo Martinez, Henika Patel, Yanwen You, Nur Jury, Abigail Perkins, Audrey Lee-Gosselin, Xavier Taylor, Yingjian You, Gonzalo Viana Di Prisco, Xiaoqing Huang, Sayan Dutta, Aruna B. Wijeratne, Javier Redding-Ochoa, Syed Salman Shahid, Juan F. Codocedo, Sehong Min, Gary E. Landreth, Amber L. Mosley, Yu-Chien Wu, David L. McKinzie, Jean-Christophe Rochet, Jie Zhang, Brady K. Atwood, Juan Troncoso, Cristian A. Lasagna-Reeves
Publikováno v:
Nature neuroscience. 25(12)
Tau aggregation is a defining histopathological feature of Alzheimer’s disease and other tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear. Here, we performed an unbiased quantitative proteomic study to identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ab07adc7639f434e9c31dd767023b0
https://pubmed.ncbi.nlm.nih.gov/36344699
https://pubmed.ncbi.nlm.nih.gov/36344699
Autor:
Brijesh Kumar, Adedeji K. Adebayo, Mayuri Prasad, Maegan L. Capitano, Ruizhong Wang, Poornima Bhat-Nakshatri, Manjushree Anjanappa, Edward Simpson, Duojiao Chen, Yunlong Liu, Jeanne M. Schilder, Austyn B. Colter, Callista Maguire, Constance J. Temm, George Sandusky, Emma H. Doud, Aruna B. Wijeratne, Amber L. Mosley, Hal E. Broxmeyer, Harikrishna Nakshatri
Publikováno v:
Science Advances
Description
Tumor tissue collection and processing under physioxia allow highly relevant detection of signaling networks and drug sensitivity.
Preclinical studies of primary cancer cells are typically done after tumors are removed from pati
Tumor tissue collection and processing under physioxia allow highly relevant detection of signaling networks and drug sensitivity.
Preclinical studies of primary cancer cells are typically done after tumors are removed from pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b339dea9706e2b0856e496bbe6f4df73
http://europepmc.org/articles/PMC8754301
http://europepmc.org/articles/PMC8754301
Autor:
Anita C. Bellail, Chunhai Hao, Chafiq Hamdouchi, Wen Jiang, Anantha Shekhar, Hong Ri Jin, Manali Ghosh, Ho Yin Lo, Ryan K. Higgins, Maximilian Blanck, Amber L. Mosley, Aruna B. Wijeratne, Jing Li, Daeho Kim, Benedict C. S. Cross, Sung Han Jung, Paula M. Hauck, Yin Quan Zhao, Carlos le Sage
Publikováno v:
Sci Transl Med
Discovery of small-molecule degraders that activate ubiquitin ligase–mediated ubiquitination and degradation of targeted oncoproteins in cancer cells has been an elusive therapeutic strategy. Here, we report a cancer cell–based drug screen of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ddb24189427eb135e924d78b3a87ab
https://doi.org/10.1126/scitranslmed.abh1486
https://doi.org/10.1126/scitranslmed.abh1486
Autor:
Tatsuyoshi Kono, Paul Sohn, Xin Tong, Carmella Evans-Molina, Farooq Syed, Wataru Yamamoto, Aruna B. Wijeratne, Amber L. Mosley, Jason D. True, Robert N. Bone, Christopher A. Reissaus
Publikováno v:
Journal of Biological Chemistry. 294:168-181
Alterations in endoplasmic reticulum (ER) calcium (Ca(2+)) levels diminish insulin secretion and reduce β-cell survival in both major forms of diabetes. The mechanisms responsible for ER Ca(2+) loss in β cells remain incompletely understood. Moreov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9ecdccb6d38ef56e58ab4e12d6baf6
https://doi.org/10.1074/jbc.ra118.005683
https://doi.org/10.1074/jbc.ra118.005683
Publikováno v:
Journal of Proteome Research
The CETSA and Thermal Proteome Profiling (TPP) analytical methods are invaluable for the study of protein-ligand interactions and protein stability in a cellular context. These tools have increasingly been leveraged in work ranging from understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e053f05c0f60555e63b2d49bc8c5f7
https://pubmed.ncbi.nlm.nih.gov/33660510
https://pubmed.ncbi.nlm.nih.gov/33660510
Autor:
Aruna B. Wijeratne, Neil A. McCracken, Sarah A. Peck Justice, Amber L. Mosley, Jose F. Victorino
The study of low abundance proteins is a challenge to discovery-based proteomics. Mass-spectrometry (MS) applications, such as thermal proteome profiling (TPP) face specific challenges in detection of the whole proteome as a consequence of the use of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9fdc9ead2d4eb25781a2d071473b3d7
https://doi.org/10.1101/2020.12.30.424894
https://doi.org/10.1101/2020.12.30.424894
Autor:
Tao Yu, George E. Sandusky, Xinna Zhang, Yifan Sun, Ka Man So, Guang Ji, Amber L. Mosley, Han-Chen Xu, Yunlong Liu, Samy O. Meroueh, Lu Zhang, Xiaoming He, Changlin Wan, Zhuolong Zhou, Cheng Huang, Xiongbin Lu, Chi Zhang, Yujing Li, Yuanzhang Fang, Degang Liu, Aruna B. Wijeratne, Michael Frieden, Kevin Van der Jeught
Publikováno v:
J Clin Invest
One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity, which arises due to lack of immunogenic tumor antigens as well as dysregulation of the antigen processing machinery. In a screen for small-molecule compounds from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b10d5692d47ca33fb6607f39a047791
https://pubmed.ncbi.nlm.nih.gov/33830945
https://pubmed.ncbi.nlm.nih.gov/33830945
Autor:
Doreen L. Eastes, Amber L. Mosley, Bradley J. Mills, Meeta Pradhan, Anna Geisinger, Daniel H. Robertson, Zane Baird, Scott M. McAhren, Aruna B. Wijeratne, Rong Qi, Anantha Shekhar, Michael Pugia
Publikováno v:
Archives of autoimmune diseases
BACKGROUNDDiabetes is a complex, multi-symptomatic disease that drives healthcare costs through its complications as the prevalence of this disease grows rapidly world-wide. Real-world electronic health records (EHRs) coupled with patient biospecimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ee24380bc15c18ca4989b6022bdf8b
https://doi.org/10.46439/autoimmune.1.004
https://doi.org/10.46439/autoimmune.1.004
Autor:
Aruna B. Wijeratne, Jo El J. Schultz, Kenneth D. Greis, Janet R. Manning, Yu Zhang, Brian Oloizia
Publikováno v:
J Mol Cell Cardiol
RATIONALE: Among its many biological roles, fibroblast growth factor 2 (FGF2) protects the heart from dysfunction and damage associated with an ischemic attack. Our laboratory demonstrated that its protection against myocardial dysfunction occurs by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d7719a0cd9bda7c96fb095c57ab353
https://europepmc.org/articles/PMC8791552/
https://europepmc.org/articles/PMC8791552/
Autor:
Aruna B. Wijeratne, Amber L. Mosley, Edward Simpson, Jonah Z. Vilseck, Jose F. Victorino, H. R. Sagara Wijeratne, Guihong D. Qi, Sarah A. Peck Justice, Monica P. Barron
Publikováno v:
J Biol Chem
Temperature-sensitive (TS) missense mutants have been foundational for characterization of essential gene function. However, an unbiased approach for analysis of biochemical and biophysical changes in TS missense mutants within the context of their f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5ec9c9135de9f846ed7af6a48fc4be
https://pubmed.ncbi.nlm.nih.gov/32878984
https://pubmed.ncbi.nlm.nih.gov/32878984