Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Aruna Asipu"'
Autor:
Christine P Diggle, Isabel Martinez-Garay, Zoltan Molnar, Martin H Brinkworth, Ed White, Ewan Fowler, Ruth Hughes, Bruce E Hayward, Ian M Carr, Christopher M Watson, Laura Crinnion, Aruna Asipu, Ben Woodman, P Louise Coletta, Alexander F Markham, T Neil Dear, David T Bonthron, Michelle Peckham, Ewan E Morrison, Eamonn Sheridan
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174264 (2017)
Tubulin alpha 8 (Tuba8) is the most divergent member of the highly conserved alpha tubulin family, and uniquely lacks two key post-translational modification sites. It is abundantly expressed in testis and muscle, with lower levels in the brain. We p
Externí odkaz:
https://doaj.org/article/018e0d0b0c5f4a439d4efb23ef2dfb63
Autor:
Christine P. Diggle, Waichi Sato, James O. Hill, Shoichi Maruyama, Aruna Asipu, Yuri Y. Sautin, Takuji Ishimoto, Tomoki Kosugi, David J. Orlicky, Christina Cicerchi, Paul S. MacLean, Rachel H. McMahan, Hugo R. Rosen, Christopher J. Rivard, Shinichiro Inaba, Carlos A. Roncal-Jimenez, Matthew R. Jackman, Miguel A. Lanaspa, Manal F. Abdelmalek, Laura G. Sánchez-Lozada, David T. Bonthron, Richard J. Johnson
Publikováno v:
Hepatology. 58:1632-1643
Fructose intake from added sugars has been implicated as a cause of nonalcoholic fatty liver disease. Here we tested the hypothesis that fructose may interact with a high-fat diet to induce fatty liver, and to determine if this was dependent on a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41d4bf13dce63aaaabe0ac28b36d1c43
https://doi.org/10.1002/hep.26594
https://doi.org/10.1002/hep.26594
Autor:
David T. Bonthron, Christine P. Diggle, Alex F. Markham, Derek Leitch, David Brooke, Ian M. Carr, Bruce E. Hayward, Aruna Asipu, Michael Shires
Publikováno v:
Journal of Histochemistry & Cytochemistry. 57:763-774
Ketohexokinase (KHK, also known as fructokinase) initiates the pathway through which most dietary fructose is metabolized. Very little is known about the cellular localization of this enzyme. Alternatively spliced KHK-C and KHK-A mRNAs are known, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5679aad32b53f0e909580cf7f2a393c8
https://doi.org/10.1369/jhc.2009.953190
https://doi.org/10.1369/jhc.2009.953190
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
The structures of the two alternatively spliced isoforms of human ketohexokinase, hepatic KHK-C and peripheral KHK-A, and of the ternary complex of KHK-A with the substrate fructose and AMP-PNP have been solved. The differences between KHK-A and KHK-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9135075e9b64e15ebc01a0369de92661
https://doi.org/10.1107/s0907444908041115
https://doi.org/10.1107/s0907444908041115
Autor:
Paul T, Manna, Tim S, Munsey, Nada, Abuarab, Fangfang, Li, Aruna, Asipu, Gareth, Howell, Alicia, Sedo, Wei, Yang, Jacqui, Naylor, David J, Beech, Lin-Hua, Jiang, Asipu, Sivaprasadarao
Publikováno v:
The Biochemical journal. 466(3)
Reactive oxygen species (ROS) can cause pancreatic β-cell death by activating transient receptor potential (melastatin) 2 (TRPM2) channels. Cell death has been attributed to the ability of these channels to raise cytosolic Ca2+. Recent studies howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3603b5493486705ab7a73211d6d59cf2
https://pubmed.ncbi.nlm.nih.gov/25562606
https://pubmed.ncbi.nlm.nih.gov/25562606
Autor:
Aruna Asipu, Asipu Sivaprasadarao, Christopher J. Partridge, Lindsey A. Mair, Malcolm Hunter, Andrew Smith
Publikováno v:
Biochemical and Biophysical Research Communications. 348:1123-1131
ATP-sensitive potassium (KATP) channels play a central role in glucose-stimulated insulin secretion (GSIS) by pancreatic beta-cells. Activity of these channels is determined by their open probability (Po) and the number of channels present in a cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3013ba2e376fe015d7f83b039d180257
https://doi.org/10.1016/j.bbrc.2006.07.170
https://doi.org/10.1016/j.bbrc.2006.07.170
Autor:
Tomoki Kosugi, Shinichiro Inaba, Laura G. Sánchez-Lozada, Gabriela E. Garcia, Yoshifuru Tamura, Wataru Kitagawa, Katsuyuki Tanabe, J. Mark Petrash, Richard J. Johnson, Takuji Ishimoto, Nanxing Li, Christopher J. Rivard, A. Ahsan Ejaz, Ana Andres-Hernando, Esteban Finol, Miguel A. Lanaspa, David J. Orlicky, Christina Cicerchi, Aruna Asipu, Wei Chen, Bernardo Rodriguez-Iturbe, Christine P. Diggle, David T. Bonthron, Takahiko Nakagawa, Yuri Y. Sautin, Carlos A. Roncal-Jimenez
Diabetes is associated with activation of the polyol pathway, in which glucose is converted to sorbitol by aldose reductase. Previous studies focused on the role of sorbitol in mediating diabetic complications. However, in the proximal tubule, sorbit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b9207d67e50a2e237b0ac4257098ff
https://europepmc.org/articles/PMC4214522/
https://europepmc.org/articles/PMC4214522/
Publikováno v:
Biochemical and Biophysical Research Communications. 288:809-818
The myelin basic proteins (MBPs) are a family of polypeptides that are predominantly expressed in the nervous system where they play a major role in myelination. We have generated four lines of transgenic mice carrying a transgene in which 1.34 kb of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457c90de804d29a09f19576810c20e45
https://doi.org/10.1006/bbrc.2001.5837
https://doi.org/10.1006/bbrc.2001.5837
Autor:
Shinichiro Inaba, Tomoki Kosugi, Christina Cicerchi, Philip A. Ruzycki, David T. Bonthron, Nanxing Li, Elise S. Bales, Miguel A. Lanaspa, Laura G. Sánchez-Lozada, James L. McManaman, David J. Orlicky, Yuri Y. Sautin, Shoichi Maruyama, Aruna Asipu, Christine P. Diggle, Christopher J. Rivard, Richard J. Johnson, J. Mark Petrash, Takuji Ishimoto, Carlos A. Roncal-Jimenez
Publikováno v:
Nature Communications. 4
Nature Communications 4: Article number: 2434 (2013); Published: 10 September 2013; Updated: 4 December 2013 The original version of this Article contained an error in the spelling of the author Philip Ruzycki, which was incorrectly given as Philip R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbbcaed1ee6ef02a562277df02250dbf
https://doi.org/10.1038/ncomms3929
https://doi.org/10.1038/ncomms3929
Autor:
Miguel A. Lanaspa, James L. McManaman, Christopher J. Rivard, Aruna Asipu, David J. Orlicky, Richard J. Johnson, J. Mark Petrash, Christina Cicerchi, Tomoki Kosugi, Shinichiro Inaba, Shoichi Maruyama, David T. Bonthron, Philip A. Ruzycki, Elise S. Bales, Laura G. Sánchez-Lozada, Christine P. Diggle, Takuji Ishimoto, Yuri Y. Sautin, Nanxing Li, Carlos A. Roncal-Jimenez
Publikováno v:
Nature communications
Carbohydrates with high glycemic index are proposed to promote the development of obesity, insulin resistance and fatty liver, but the mechanism by which this occurs remains unknown. High serum glucose concentrations glucose are known to induce the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531f51d1fd1984198a3a0b4e993eeaa6
https://doi.org/10.1038/ncomms3434
https://doi.org/10.1038/ncomms3434