Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Arun T. Pores Fernando"'
Autor:
Nathalie Faure, Thomas M. Roberts, Elizabeth A. White, Cecile Rouleau, Arun T. Pores Fernando, Tao Jiang, Justin H. Hwang, Brian Schaffhausen
Publikováno v:
Journal of virology. 90(16)
Murine polyomavirus has repeatedly provided insights into tumorigenesis, revealing key control mechanisms such as tyrosine phosphorylation and phosphoinositide 3-kinase (PI3K) signaling. We recently demonstrated that polyomavirus small T antigen (ST)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6088d52f309600a1942cbd10a3d09ec
https://pubmed.ncbi.nlm.nih.gov/27194756
https://pubmed.ncbi.nlm.nih.gov/27194756
Publikováno v:
Journal of Biological Chemistry. 284:25107-25115
Cytotoxic T cells kill virus-infected cells and tumor cells by releasing lytic granules that contain cell-killing contents. Exocytosis requires calcium influx and protein kinase C (PKC) activation. Here, we extend our previous finding regarding the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17d64e8991f6a4999c87dd55b29b9e1
https://doi.org/10.1074/jbc.m109.011866
https://doi.org/10.1074/jbc.m109.011866
Autor:
Arun T. Pores-Fernando, Jakub P. Bartnik, Adam Zweifach, Georjeana A. Wurth, Michael J. Grybko
Publikováno v:
Journal of Biological Chemistry. 282:18009-18017
We have tested the idea that calcineurin, a calcium-dependent phosphatase that is critical for activating cytokine gene expression in helper T cells, plays a role in lytic granule exocytosis in cytotoxic T lymphocytes (CTLs). We used TALL-104 human l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3473ac6aba20b0ac0c265d2b44068c
https://doi.org/10.1074/jbc.m702222200
https://doi.org/10.1074/jbc.m702222200
Publikováno v:
The Journal of Physiology. 567:891-903
Cytotoxic T lymphocytes kill targets via secretion of lytic agents including perforin and granzymes. Recently, new methods have been developed to monitor cytotoxic T lymphocyte degranulation. These include detecting the appearance of lysosome-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4cf427e0af116512f54c11fa01bff78
https://doi.org/10.1113/jphysiol.2005.089565
https://doi.org/10.1113/jphysiol.2005.089565
Autor:
Thomas M. Roberts, Peter M. Howley, Elizabeth A. White, Nana Naetar, Arun T. Pores Fernando, Brian Schaffhausen, Rebecca Kramer, William C. Hahn, Justin H. Hwang, David M. Livingston
Publikováno v:
Journal of virology. 89(5)
Many of the small DNA tumor viruses encode transforming proteins that function by targeting critical cellular pathways involved in cell proliferation and survival. In this study, we have examined whether some of the functions of the polyomavirus smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e99bbf5f207cf50dc7a609303161a7c
https://pubmed.ncbi.nlm.nih.gov/25540383
https://pubmed.ncbi.nlm.nih.gov/25540383
Autor:
Arun T. Pores Fernando, Shaida Andrabi, Justin H. Hwang, Nathalie Faure, Thomas M. Roberts, Brian Schaffhausen, William C. Hahn
Publikováno v:
Journal of virology. 88(20)
Murine polyomavirus small t antigen (PyST) regulates cell cycle, cell survival, apoptosis, and differentiation and cooperates with middle T antigen (MT) to transform primary cells in vitro and in vivo . Like all polyomavirus T antigens, PyST function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a81913f85ad989f9d8faa929d8d7ef7
https://pubmed.ncbi.nlm.nih.gov/26041839
https://pubmed.ncbi.nlm.nih.gov/26041839
Autor:
Adam Zweifach, Arun T. Pores-Fernando
Publikováno v:
Immunological reviews. 231(1)
Cytotoxic T lymphocytes (CTLs) kill targets by releasing cytotoxic agents from lytic granules. Killing is a multi-step process. The CTL adheres to a target, allowing its T-cell receptors to recognize antigen. This triggers a signal transduction casca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf47b6408e18c61fd146b820b4d8cdb2
https://pubmed.ncbi.nlm.nih.gov/19754896
https://pubmed.ncbi.nlm.nih.gov/19754896
Cytotoxic T cells (CTLs) and natural killer cells (NKs) both kill virus-infected cells and tumor cells by releasing the cytoxic contents of their lytic granules. We recently demonstrated a role for calcineurin in lytic granule exocytosis in TALL-104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ab30af3dfd0c5dc8d3869c2cc1c882
https://europepmc.org/articles/PMC2646370/
https://europepmc.org/articles/PMC2646370/
Publikováno v:
Biochemical and biophysical research communications. 371(4)
Cytotoxic T cells (CTLs) kill target cells by releasing lytic agents via regulated exocytosis. Three signals are known to be required for exocytosis: an increase in intracellular Ca(2+), activation of protein kinase C (PKC) and activation of extracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46103e436659107ed4a2aa3c4869d497
https://pubmed.ncbi.nlm.nih.gov/18413231
https://pubmed.ncbi.nlm.nih.gov/18413231
Publikováno v:
Journal of leukocyte biology. 81(2)
CTLs kill virus-infected, tumor, and transplanted targets via secretion of lytic agents including perforin and granzymes. Knowledge of the signals controlling this important process remains vague. We have tested the idea that protein kinase C (PKC)θ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a61a24d3e6734a3da6190eb2b63f0fd
https://pubmed.ncbi.nlm.nih.gov/17077164
https://pubmed.ncbi.nlm.nih.gov/17077164