ALDH1A3 is the switch that determines the balance of ALDH ⁺ and CD24 ^- CD44 ⁺ cancer stem cells, EMT-MET, and glucose metabolism in breast cancer.

Autor: Fernando W; Department of Pathology, Dalhousie University, Halifax, NS, Canada.; Department of Biology, Acadia University, Wolfville, NS, Canada., Cruickshank BM; Department of Pathology, Dalhousie University, Halifax, NS, Canada.; Department of Surgery, Dalhousie University, Halifax, NS, Canada., Arun RP; Department of Pathology, Dalhousie University, Halifax, NS, Canada., MacLean MR; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Cahill HF; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Morales-Quintanilla F; Department of Biology, Faculty of Science, Saint Mary's University, Halifax, NS, Canada., Dean CA; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Wasson MD; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Dahn ML; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Coyle KM; Department of Pathology, Dalhousie University, Halifax, NS, Canada.; Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Walker OL; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Power Coombs MR; Department of Pathology, Dalhousie University, Halifax, NS, Canada.; Department of Biology, Acadia University, Wolfville, NS, Canada., Marcato P; Department of Pathology, Dalhousie University, Halifax, NS, Canada. paola.marcato@dal.ca.; Department of Microbiology & Immunology, Dalhousie University, Halifax, NS, Canada. paola.marcato@dal.ca.; Nova Scotia Health Authority, Halifax, NS, Canada. paola.marcato@dal.ca.

Publikováno v: Oncogene [Oncogene] 2024 Oct; Vol. 43 (43), pp. 3151-3169. Date of Electronic Publication: 2024 Sep 09.

ALDH1A3 promotes invasion and metastasis in triple-negative breast cancer by regulating the plasminogen activation pathway.

Autor: Bharadwaj AG; Department of Pathology, Dalhousie University, Halifax, Canada., McLean ME; Department of Pathology, Dalhousie University, Halifax, Canada., Dahn ML; Department of Pathology, Dalhousie University, Halifax, Canada., Cahill HF; Department of Pathology, Dalhousie University, Halifax, Canada., Wasson MD; Department of Pathology, Dalhousie University, Halifax, Canada., Arun RP; Department of Pathology, Dalhousie University, Halifax, Canada., Walker OL; Department of Pathology, Dalhousie University, Halifax, Canada., Cruickshank BM; Department of Surgery, Dalhousie University, Halifax, Canada., Fernando W; Department of Pathology, Dalhousie University, Halifax, Canada., Venkatesh J; Department of Pathology, Dalhousie University, Halifax, Canada., Barnes PJ; Department of Pathology, Dalhousie University, Halifax, Canada., Bethune G; Department of Pathology, Dalhousie University, Halifax, Canada., Knapp G; Department of Surgery, Dalhousie University, Halifax, Canada., Helyer LK; Department of Surgery, Dalhousie University, Halifax, Canada., Giacomantonio CA; Department of Pathology, Dalhousie University, Halifax, Canada.; Department of Surgery, Dalhousie University, Halifax, Canada., Waisman DM; Department of Pathology, Dalhousie University, Halifax, Canada.; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada., Marcato P; Department of Pathology, Dalhousie University, Halifax, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada.; Nova Scotia Health Authority, Halifax, Canada.

Publikováno v: Molecular oncology [Mol Oncol] 2024 Jan; Vol. 18 (1), pp. 91-112. Date of Electronic Publication: 2023 Oct 09.

Breast Cancer Subtype-Specific miRNAs: Networks, Impacts, and the Potential for Intervention.

Autor: Arun RP; Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada., Cahill HF; Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada., Marcato P; Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada.; Department of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada.; Nova Scotia Health Authority, Halifax, NS B3H 2YN, Canada.

Publikováno v: Biomedicines [Biomedicines] 2022 Mar 11; Vol. 10 (3). Date of Electronic Publication: 2022 Mar 11.

Bacterial diversity and functional analysis of severe early childhood caries and recurrence in India.

Autor: Kalpana B; Department of Biotechnology, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.; Department of Biotechnology, K. S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India., Prabhu P; Department of Biotechnology, K. S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India., Bhat AH; Department of Biotechnology, K. S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India., Senthilkumar A; Department of Biotechnology, K. S. Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India., Arun RP; Department of Biotechnology, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India., Asokan S; Department of Pediatric Dentistry, K. S. R Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India., Gunthe SS; Department of Civil Engineering, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India., Verma RS; Department of Biotechnology, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India. vermars@iitm.ac.in.; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Block 1, Room No. 201, Chennai, 600036, India. vermars@iitm.ac.in.

Publikováno v: Scientific reports [Sci Rep] 2020 Dec 04; Vol. 10 (1), pp. 21248. Date of Electronic Publication: 2020 Dec 04.

Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP.

Autor: Arun RP; Stem Cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology Madras, Chennai, 600036 TN, India., Sivanesan D; Stem Cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology Madras, Chennai, 600036 TN, India., Patra B; Stem Cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology Madras, Chennai, 600036 TN, India., Varadaraj S; Stem Cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology Madras, Chennai, 600036 TN, India., Verma RS; Stem Cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology Madras, Chennai, 600036 TN, India. vermars@iitm.ac.in.

Publikováno v: Scientific reports [Sci Rep] 2019 Jul 23; Vol. 9 (1), pp. 10684. Date of Electronic Publication: 2019 Jul 23.