Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Arun Mahesh"'
Autor:
Mohammed Inayatullah, Arun Mahesh, Arran K Turnbull, J Michael Dixon, Rachael Natrajan, Vijay K Tiwari
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 823-853 (2024)
Abstract Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, characterized by extensive intratumoral heterogeneity, high metastasis, and chemoresistance, leading to poor clinical outcomes. Despite progress, the mechanis
Externí odkaz:
https://doaj.org/article/f9d72b0bea3548a1b9749e30da03cd30
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-17 (2024)
Abstract Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype characterised by extensive intratumoral heterogeneity, high rates of metastasis and chemoresistance, leading to poor clinical outcomes. Despite progress, the m
Externí odkaz:
https://doaj.org/article/0f0ed7b53d2140eea8fdbefcc2af36b4
Autor:
Marc Fuchs, Clara Radulescu, Miao Tang, Arun Mahesh, Deborah Lavin, Syed Umbreen, James McKenna, Mark Smyth, Eilís McColgan, Zoltan Molnar, Chris Baxter, Timofey Skvortsov, Aditi Singh, Fiona Rogan, Julia Miskelly, Stephen Bridgett, Derek Fairley, David A. Simpson
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background The COVID-19 pandemic has highlighted the importance of whole genome sequencing (WGS) of SARS-CoV-2 to inform public health policy. By enabling definition of lineages it facilitates tracking of the global spread of the virus. The
Externí odkaz:
https://doaj.org/article/d0a26f61b2eb437880f7f489c8826b77
Autor:
Mamta Verma, Mohd. Imran K. Khan, Rajashekar Varma Kadumuri, Baskar Chakrapani, Sharad Awasthi, Arun Mahesh, Gayathri Govindaraju, Pavithra L Chavali, Arumugam Rajavelu, Sreenivas Chavali, Arunkumar Dhayalan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Here, the authors demonstrate that protein arginine methyltransferase 3 (PRMT3) interacts with and inhibits the retinal dehydrogenase ALDH1A1, negatively regulating the expression of retinoic acid responsive genes. This study shows that PRMT3 affects
Externí odkaz:
https://doaj.org/article/8217d811b7904b0782645e59d929fb2e
Deciphering the gene regulatory circuitry governing chemoresistance in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, due in part to extensive intratumoral heterogeneity, high rates of metastasis and chemoresistance, leading to poor clinical outcomes. Despite progress, the mechanistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748d2e98c60b4dba1092c8f3e2090438
https://doi.org/10.1101/2023.05.05.539623
https://doi.org/10.1101/2023.05.05.539623
Autor:
Aditi Singh, Arun Mahesh, Florian Noack, Beatriz Cardoso de Toledo, Federico Calegari, Vijay K. Tiwari
Publikováno v:
Singh, A, Mahesh, A, Noack, F, Cardoso de Toledo, B, Calegari, F & Tiwari, V K 2022, ' Tcf12 and NeuroD1 cooperatively drive neuronal migration during cortical development. ', Development (Cambridge, England), vol. 149, no. 3 . https://doi.org/10.1242/dev.200250
Corticogenesis consists of a series of synchronised events, including fate transition of cortical progenitors, neuronal migration, specification and connectivity. NeuroD1, a basic helix-loop-helix (bHLH) transcription factor (TF), contributes to all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af3faabc51e726743482afcc731a253
https://pure.qub.ac.uk/en/publications/fd8bcbf3-8176-474b-ac17-5b502fca0136
https://pure.qub.ac.uk/en/publications/fd8bcbf3-8176-474b-ac17-5b502fca0136
Autor:
Arun Mahesh, Pavithra L. Chavali, Rajashekar Varma Kadumuri, Baskar Chakrapani, Sreenivas Chavali, Mamta Verma, Gayathri Govindaraju, Arumugam Rajavelu, Sharad Awasthi, Arunkumar Dhayalan, Mohd. Imran K. Khan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology
Communications Biology
Protein arginine methyltransferase 3 (PRMT3) regulates protein functions by introducing asymmetric dimethylation marks at the arginine residues in proteins. However, very little is known about the interaction partners of PRMT3 and their functional ou
Autor:
Arunkumar Dhayalan, Mohane Selvaraj Coumar, Hsing Pang Hsieh, Shu Yu Lin, M. Ramya Chandar Charles, Arun Mahesh
Publikováno v:
Biochimie. 168:220-230
G9a (also known as EHMT2 - Euchromatin histone methyltransferase 2) is a protein lysine methyltransferase which introduces methylation modification in variety of proteins including histones. G9a catalyzes the dimethylation of lysine 9 on histone 3 (H
Autor:
Sanjeeb Kumar Sahu, Eneritz Agirre, Mohammed Inayatullah, Arun Mahesh, Neha Tiwari, Deborah P. Lavin, Aditi Singh, Susanne Strand, Mustafa Diken, Reini F. Luco, Juan Carlos Izpisua Belmonte, Vijay K. Tiwari
Publikováno v:
Nature cell biology. 24(8)
Epithelial-to-mesenchymal transition (EMT) renders epithelial cells migratory properties. While epigenetic and splicing changes have been implicated in EMT, the mechanisms governing their crosstalk remain poorly understood. Here we discovered that a
Autor:
Marc-Aurel Fuchs, Arun Mahesh, Clara Radulescu, Deborah Lavin, Fiona Rogan, Julia Miskelly, Stephen Bridgett, David Simpson
We present the ‘mini-XT’ miniaturized tagmentation-based library preparation protocol used for Illumina WGS of SARS-CoV-2 positive samples. Reverse transcription and amplification is based upon the nCoV-2019 sequencing protocol v3 (LoCost)V.3 by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2fd638dd90d209cb1fc972f59f9842
https://doi.org/10.17504/protocols.io.bvntn5en
https://doi.org/10.17504/protocols.io.bvntn5en