Visualizing replication fork encounters with DNA interstrand crosslinks

Autor: Ryan C James, Jing Zhang, Arun K. Thazhathveetil, Marina A. Bellani, Himabindu Gali, Julia Gichimu, Althaf Shaik, Jing Huang, Michael M. Seidman, Durga Pokharel

Publikováno v: Methods Enzymol

Replication forks encounter numerous challenges as they move through eu- and hetero-chromatin during S phase in mammalian cells. These include a variety of impediments to the unwinding of DNA by the replicative helicase such as alternate DNA structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce524e7c2eb64fac36a0846dcb05856
https://europepmc.org/articles/PMC10035509/

High-Energy Long-Lived Mixed Frenkel-Charge-Transfer Excitons: From Double Stranded (AT) n to Natural DNA

Autor: Irene Burghardt, Arun K. Thazhathveetil, Thomas Gustavsson, Frederick D. Lewis, Dimitra Markovitsi, Roberto Improta, Miquel Huix-Rotllant, Ignacio Vayá, Johanna Brazard

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, 2016, 22, pp.1-12. ⟨10.1002/chem.201504007⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2016, 22, pp.1-12. ⟨10.1002/chem.201504007⟩

International audience; The electronic excited states populated upon absorption of UV photons by DNA are extensively studied in relation to the UV-induced damage to the genetic code. Here, we report a new unexpected relaxation pathway in adenine–th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b429a9250e8fefae578816e53e5d5f5
https://doi.org/10.1002/chem.201504007

Efficient Charge Transport via DNA G-Quadruplexes

Autor: Michelle A. Harris, Michael R. Wasielewski, Arun K. Thazhathveetil, Ryan M. Young, Frederick D. Lewis

Publikováno v: Journal of the American Chemical Society. 139(5)

The dynamics and efficiency of photoinduced charge transport has been investigated in DNA capped hairpins possessing a stilbenedicarboxamide (Sa) hole donor and stilbenediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7157078665ec0cf540c248e7244a2e
https://pubmed.ncbi.nlm.nih.gov/28094928

The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks

Autor: Yinsheng Wang, Marina A. Bellani, Arun K. Thazhathveetil, Chen Ling, Shuo Liu, Jing Huang, Michael M. Seidman, Weidong Wang, Johan P. de Winter

Publikováno v: Huang, J, Liu, S, Bellani, M A, Thazhathveetil, A K, Ling, C, de Winter, J P, Wang, Y S, Wang, W D & Seidman, M M 2013, ' The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks ', Molecular Cell, vol. 52, no. 3, pp. 434-446 . https://doi.org/10.1016/j.molcel.2013.09.021
Molecular Cell, 52(3), 434-446. Cell Press

The replicative machinery encounters many impediments, some of which can be overcome by lesion bypass or replication restart pathways, leaving repair for a later time. However, interstrand crosslinks (ICLs), which preclude DNA unwinding, are consider

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46588919f01c2a6ac5fa5904c35d6a3

Ultrafast Excited-State Dynamics in Hexaethyleneglycol-Linked DNA Homoduplexes Made of A·T Base Pairs

Autor: Frederick D. Lewis, Jinquan Chen, Bern Kohler, Arun K. Thazhathveetil

Publikováno v: Journal of the American Chemical Society. 135:10290-10293

Double-stranded DNA conjugates with the sequence (dA)10·(dT)10 and hexaethylene glycol linkers at one end (hairpin) or both ends (dumbbell) were studied in buffer solution by deep UV femtosecond transient absorption spectroscopy. These covalently co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb582c5359451cceea48848ffba8534d
https://doi.org/10.1021/ja4049459