Výsledky vyhledávání - "Arun K. Kashyap"

260 CD47 antibody, AO-176 demonstrates potent anti-tumor activity in pre-clinical solid tumor xenografts as a single agent and in combination with multiple classes of therapeutics

Autor: Ronald R. Hiebsch, Robyn J Puro, Casey Wilson, Rachel Delston, Daniel S. Pereira, Arun K. Kashyap, Benjamin J. Capoccia, Michael J. Donio, Gabriela Andrejeva

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundCD47 is a cell surface protein expressed on tumors that binds SIRPα on macrophages and dendritic cells resulting in a ”don’t eat me” signal that allows tumors to evade phagocytosis. The highly differentiated monoclonal antibody, AO-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee292c6258da9bb2fc86fcd25d2fc1e
https://doaj.org/article/5ea9add8ab9d4c4297ee134cebe5d2b2

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Congenital diarrhea in a newborn infant: A case report

Autor: Arun K Kashyap, Mehrin Sadiq, Omer Choudry, Danitza M Velazquez

Publikováno v: World Journal of Clinical Pediatrics

Background Microvillus inclusion disease (MVID) is a rare autosomal recessive cause of severe congenital diarrhea with significant morbidity and mortality. Definitive treatment involves bowel transplant. The diagnosis of this condition can be challen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170c175c35557ea89d35c60eb74a8c3b
https://doi.org/10.5409/wjcp.v8.i3.43

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215 AO-176, a highly differentiated clinical stage anti-CD47 antibody, preferentially binds tumor versus normal cell CD47 when complexed to β1 integrin

Autor: John R. Richards, Daniel S. Pereira, Robyn J Puro, Arun K Kashyap, Vicki Sung, Ronald R. Hiebsch, Prabir Chakraborty, W. Casey Wilson, Michael J. Donio, Carrie Baker Brachmann, Benjamin J. Capoccia

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Background Overexpression of CD47 by tumor cells exploits an immune checkpoint preventing tumor recognition and destruction by innate immune cells. Binding of tumor CD47 to SIRPα on macrophages and dendritic cells triggers a ‘don’t eat me’ sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf553c0b15649e4e49fce94c84be056
https://doaj.org/article/b1c4691d570a499f94d4b96fa9ac0ba2

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Akademický článek

Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries.

Autor: Arun K Kashyap, John Steel, Adam Rubrum, Angeles Estelles, Raffaella Briante, Natalia A Ilyushina, Li Xu, Ryann E Swale, Aleksandr M Faynboym, Pamela K Foreman, Michael Horowitz, Lawrence Horowitz, Richard Webby, Peter Palese, Richard A Lerner, Ramesh R Bhatt

Publikováno v: PLoS Pathogens, Vol 6, Iss 7, p e1000990 (2010)

Influenza viruses elude immune responses and antiviral chemotherapeutics through genetic drift and reassortment. As a result, the development of new strategies that attack a highly conserved viral function to prevent and/or treat influenza infection

Externí odkaz: https://doaj.org/article/6215bc65a50e44a2b76bc04a259a4c3f

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AO-176, a Differentiated Clinical-Stage Anti-CD47 Antibody, Demonstrates Potent Anti-Tumor Activity across Multiple Preclinical Models of B Cell Neoplasms

Autor: John O. Richards, Arun K Kashyap, Mike J Donio, Daniel S. Pereira, Robyn J Puro, Gabriela Andrejeva, Ronald R. Hiebsch, Benjamin J. Capoccia, William C. Wilson

Publikováno v: Blood. 138:2277-2277

Upregulation of CD47, the "don't eat me" signal, on the surface of tumors to evade immune surveillance is a common escape mechanism utilized during hematological malignancy and solid tumor development, progression, and relapse. We recently reported t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37bd47dac7e3b93fc028bb7375979957
https://doi.org/10.1182/blood-2021-152896

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Pre-Clinical Combination of AO-176, a Highly Differentiated Clinical Stage CD47 Antibody, with Either Azacitidine or Venetoclax Significantly Enhances DAMP Induction and Phagocytosis of Acute Myeloid Leukemia

Autor: Mike J Donio, Daniel S. Pereira, Robyn J Puro, Benjamin J. Capoccia, W. Casey Wilson, Isra M. Darwech, Gabriela Andrejeva, Arun K Kashyap

Publikováno v: Blood. 136:9-10

While T cell checkpoint inhibitors are mainstays of cancer immunotherapy, therapies that direct innate immune responses against cancer are lacking. CD47, a "don't eat me" signal, is an innate immune cell checkpoint which binds SIRPα on macrophages a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55374beb68c6604ac9983abbd0087f4f
https://doi.org/10.1182/blood-2020-140528

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Dual Agonist Surrobody Simultaneously Activates Death Receptors DR4 and DR5 to Induce Cancer Cell Death

Autor: John C. Reed, Snezana Milutinovic, Teruki Yanagi, Arun K. Kashyap, Sihong Zhou, Shu-ichi Matsuzawa, Ryann O'Neil, Michael Horowitz, Ramesh R. Bhatt, Carina Wimer, Charles H. Hannum, Aaron L. Kurtzman, Lawrence Horowitz, Alexsandr Faynboym, Paul Diaz, Li Xu

Publikováno v: Molecular Cancer Therapeutics. 15:114-124

Death receptors of the TNF family are found on the surface of most cancer cells and their activation typically kills cancer cells through the stimulation of the extrinsic apoptotic pathway. The endogenous ligand for death receptors 4 and 5 (DR4 and D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a55be4349e5676bc07de4a847f827fc
https://doi.org/10.1158/1535-7163.mct-15-0400

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