Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Arun K. Agrawal"'
Publikováno v:
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH. :77-82
Ethno-medicinal survey was undertaken from traditional healers of Bhutia tribal community of Urrarkashi district for the use of medicinal plants in the treatment of different skin diseases such as dog and insect bite, burns, eczema, abscesses, scabie
Autor:
Xinmin Gan, Laurence Philippe, Brian Sanchez, Karen M. Yates, Ziqiang Wang, Arun K. Agrawal, Pil H. Lee, Cho Ming Loi, Zhen Lou, Haile Tecle, Jo Ann Dumin, Sheila Guppy, Frank Riley, Joan K. Brieland, Christopher James Deur, Sally Przybranowski, Brian Samas, Amy Mae Bunker, Mark Morris, Michael William Wilson, John Richard Booth, Joseph A. Cornicelli, Susan E. Bove, Cleo J. C. Connolly, Gregg Kamilar, Kenneth S. Kilgore, Barry C. Finzel, Heidi Baum, Kathryn A. Welch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4599-4603
It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the trea
Autor:
Conrad Santini, Joel P. Berger, Guo Q. Shi, James V. Heck, Melba Hernandez, Raul F. Alvaro, Yong Zhang, Arun K. Agrawal, Soumya P. Sahoo, James F. Dropinski, Samuel D. Wright, Tian-Quan Cai, Gaochao Zhou, Peter T. Meinke, David E. Moller, Karen L. MacNaul
Publikováno v:
Journal of Medicinal Chemistry. 48:5589-5599
The design and synthesis of a novel class of 2,3-dihydrobenzofuran-2-carboxylic acids as highly potent and subtype-selective PPARalpha agonists are reported. Systematic study of structure-activity relationships has identified several key structural e
Autor:
Soumya P. Sahoo, Samuel D. Wright, David E. Moller, Julia K. Boueres, Karen L. MacNaul, Marc C. Ippolito, Joel P. Berger, Arun K. Agrawal, Daniel J. Miller, Pei-Ran Wang, Hiroo Koyama
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3347-3351
A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARα agonisim. As a result, highly potent, and selective PPARα agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in ha
Autor:
Arun K. Agrawal, Thomas W. Doebber, Pei-Ran Wang, Daniel J. Miller, James V. Heck, Julia K. Boueres, Marc C. Ippolito, Soumya P. Sahoo, Linda J. Kelly, Samuel D. Wright, Yu-Sheng Chao, Hiroo Koyama, A. Brian Jones, Gaochao Zhou, Joel P. Berger, David E. Moller, Ronald B. Franklin, Karen L. MacNaul, Ranjit C. Desai, Margaret Wu
Publikováno v:
Journal of Medicinal Chemistry. 47:3255-3263
A series of chromane-2-carboxylic acid derivatives was synthesized and evaluated for PPAR agonist activities. A structure-activity relationship was developed toward PPARalpha/gamma dual agonism. As a result, (2R)-7-(3-[2-chloro-4-(4-fluorophenoxy)phe
Autor:
Arun K. Agrawal, Bernard H. Shapiro
Publikováno v:
Drug Metabolism and Disposition. 31:612-619
Numerous studies, usually limited to male rodents, have reported an inverse relationship between the age of the animal and the activities of various multi-cytochrome P450-dependent drug-metabolizing enzymes. It has been suggested that the aging-induc
Autor:
Im-Chul Shin, Ki-Wan Oh, Hiroyuki Tanaka, Jin-Tae Hong, Yutaka Terata, M. Zafer Gören, Naoyo Sano, Hiroyuki Watanabe, Hitoshi Hasegawa, Rezzan Aker, Daniel H. Sturn, Filiz Onat, H. Raci Yananlı, Yoshikatsu Chiba, Mamoru Miura, Christian J. Wiedermann, Christian Meierhofer, Arun K. Agrawal, Stefan Dunzendorfer, Yoshimasa Fujiwara, Nicole C. Kaneider, Bernard H. Shapiro, Hyoung-Chun Kim, Satoshi Kibira, Hiroto Miura, Helmut Allmeier, Angela Djanani, Jeffrey W. Swanson, Hajime Takikawa, Takashi Saito
Publikováno v:
Pharmacology. 68:217-220
Autor:
Bernard H. Shapiro, Arun K. Agrawal
Publikováno v:
Pharmacology. 68:204-215
Newborn male and female rats were treated with therapeutic-like levels of phenobarbital to determine whether early exposure to the barbiturate permanently alters (i.e., imprints) mechanisms regulating induction of constituent CYP (cytochrome P-450) i
Publikováno v:
CORROSION. 55:1101-1109
Hydrogen-induced cracking (HIC) and stress-oriented hydrogen-induced cracking (SOHIC) tests were conducted on a conventional type A516-70 (UNS K02700) pressure vessel steel exposed to hydr...
Publikováno v:
Biochemical Pharmacology. 56:1251-1258
The interactions of gender, growth hormone, and phenobarbital induction on Cyp2b expression were examined in phenotypically normal ( lit/+ ) and growth-hormone deficient “little” ( lit/lit ) mice. Using an immunocrossreactive monoclonal antibody