Molecular Mechanisms of Pharmaceutical Drug Binding into Calsequestrin

Autor: Kevin M. Lewis, Emiliano J. Sanchez, Hendrik Milting, Arun K Subra, ChulHee Kang, Ashwin K Muralidharan, Mark S. Nissen

Publikováno v: International Journal of Molecular Sciences, Vol 13, Iss 11, Pp 14326-14343 (2012)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 13; Issue 11; Pages: 14326-14343

Calsequestrin (CASQ) is a major Ca2+-storage/buffer protein present in the sarcoplasmic reticulum of both skeletal (CASQ1) and cardiac (CASQ2) muscles. CASQ has significant affinity for a number of pharmaceutical drugs with known muscular toxicities.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23569dace245ed608dbf20ba448cfd6
https://doi.org/10.3390/ijms131114326